Search Results - edward+d%27antonio

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Therapeutic gossypol-based inhibitors of glucose kinases for parasitic diseases

Reference #: 01658 The University of South Carolina is offering licensing opportunities for therapeutic gossypol-based inhibitors of glucose kinases for parasitic diseases. Background: Trypanosoma cruzi and Trypanosoma brucei, which are protozoan parasites pathogenic to the human host are the etiological agents of Chagas' disease and human African...

Published: 10/30/2024 | Inventor(s): Edward D'antonio

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Category(s): Biomedical and Life Sciences

One-Step Synthesis of Phosphate-Based Inhibitors and Applications Thereof

Reference #: 01236 The University of South Carolina is offering licensing opportunities for using ribose 5-phosphate isomerase inhibitors to treat against kinetoplastid parasites. Background Trypanosoma cruzi protozoa are the causative agent for Chagas’ disease, a neglected tropical disease that affects 6 – 7 million people worldwide....

Published: 6/7/2021 | Inventor(s): Edward D'antonio, Joshua Pierce

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Category(s): Health Sciences, Biomedical and Life Sciences

Inhibitors of Glucose Kinases: Update 2-27-2019

Reference #: 01401 The University of South Carolina is offering licensing opportunities for Monosaccharide Amine and 3-Nitro-2-Phenyl-2H-Chromene Based Inhibitors of Glucose Kinases Background: When a kissing bug bites a human, they can be infected with a Kinetoplastid parasite such as Trypanosoma cruzi (T. cruzi). A need exists for new drugs that...

Published: 9/4/2022 | Inventor(s): Edward D'antonio

Keywords(s): African Sleeping Sickness, Chagas' Disease, drug discovery, Glucokinase, Glucose Kinases, Glycolysis, Hexokinase, High-Throughput Screen, HTS, inhibitor, Inhibitor constant (Ki), Leishmanisis, Parasite, Parasitic Infections, Pentose Phosphate Pathway, Trypanosoma brucei, Trypanosoma cruzi, Trypanosome

Category(s): Chemistry and Biochemistry, Biomedical and Life Sciences

Cysteine-Modifying Substrate Analogue Inhibitors of Ribose 5-Phosphate Isomerase

Reference #: 01181 The University of South Carolina is offering licensing opportunities for strong selective inhibitors of the ribose 5-phosphate isomerase enzyme as new drug alternatives to commonly prescribed therapies for Chagas’ disease, African sleeping sickness, and leishmaniasis.Invention Description: Kinetoplastid parasites such as Trypanosoma...

Published: 5/27/2021 | Inventor(s): Edward D'antonio

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Category(s): Biomedical and Life Sciences, Chemistry and Biochemistry, Health Sciences

Therapeutic Inhibitors of Hexokinase and Glucokinase

Reference #: 01133 The University of South Carolina is offering licensing opportunities for new enzyme inhibitors for therapeutic drugs that treat diseases caused by trypanosomal parasites including Chagas’ disease and African sleeping sickness. Invention Description: Trypanosomal parasites, such as Trypansoma cruzi and Trypansoma brucei, utilize...

Published: 5/27/2021 | Inventor(s): Edward D'antonio, Jennifer D'antonio

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Category(s): Biomedical and Life Sciences, Health Sciences, Chemistry and Biochemistry