Search Results - drug+discovery

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Abbapolins as Inhibitors and Degraders of Polo-Like Kinases

Reference #: 01593 The University of South Carolina is offering licensing opportunities for Abbapolins as Inhibitors and Degraders of Polo-Like Kinases Background: There are no effective treatments for castration-resistant prostate cancers as all current therapies eventually fail. Invention Description: Novel chemicals called abbapolins are described...

Published: 4/2/2024 | Inventor(s): Campbell Mcinnes, Michael Wyatt, Danda Chapagai, Jessy Stafford, Gursanker Ramamoorthy

Keywords(s): abbapolin, drug discovery, peptide, Polo Like Kinase

Category(s): Biomedical and Life Sciences, Health Sciences

Temperature Responsive Cell Culture Platform for Mechanobiological Manipulation

Reference #: 01436 The University of South Carolina is offering licensing opportunities for Temperature Responsive Cell Culture Platform for Mechanobiological Manipulation Background: The invention pertains to a swellable platform with surface microwells of various shapes that can encapsulate and systematically apply mechanical pressure on cells....

Published: 9/4/2022 | Inventor(s): Ehsan Jabbarzadeh, Christopher Wu

Keywords(s): Antigen uptake, Cell culture platform, Cell secretome, Cellular Engineering, drug delivery, drug discovery, Gene transfection, Intracellular delivery, Mechanobiology, Mechanostimulation, PNIPAM

Category(s): Health Sciences, Biomedical and Life Sciences, Chemistry and Biochemistry

A Gene to Transcriptome Association Platform for Drug Target Identification

Reference #: 01465 The University of South Carolina is offering licensing opportunities for A Gene to Transcriptome Association platform for drug target identification Background: Data accumulation through genomic and transcriptomic analyses require novel tools/strategies for the extraction of biologically relevant and clinically useful information....

Published: 1/2/2024 | Inventor(s): Ioulia Chatzistamou, Hippokratis Kiaris, Youwen Zhang

Keywords(s): AI, artificial intelligence, drug discovery, target identification

Category(s): Health Sciences, Biomedical and Life Sciences

Inhibitors of Glucose Kinases: Update 2-27-2019

Reference #: 01401 The University of South Carolina is offering licensing opportunities for Monosaccharide Amine and 3-Nitro-2-Phenyl-2H-Chromene Based Inhibitors of Glucose Kinases Background: When a kissing bug bites a human, they can be infected with a Kinetoplastid parasite such as Trypanosoma cruzi (T. cruzi). A need exists for new drugs that...

Published: 9/4/2022 | Inventor(s): Edward D'antonio

Keywords(s): African Sleeping Sickness, Chagas' Disease, drug discovery, Glucokinase, Glucose Kinases, Glycolysis, Hexokinase, High-Throughput Screen, HTS, inhibitor, Inhibitor constant (Ki), Leishmanisis, Parasite, Parasitic Infections, Pentose Phosphate Pathway, Trypanosoma brucei, Trypanosoma cruzi, Trypanosome

Category(s): Chemistry and Biochemistry, Biomedical and Life Sciences