Latest technologies from University of South Carolina

A Contactless and Camera-Free Technology for Gait Assessment

technology@sc.edu — Tue, 17 Feb 2026 11:22:12 GMT

Reference #: 1756 The University of South Carolina is offering licensing opportunities for A Contactless and Camera-Free Technology for Gait Assessment. Background: Human gait, the pattern of walking, involves the movement of the body’s center of gravity and serves as an essential indicator of overall health. Metrics such as gait speed, step length, stride length, and cadence, are critical for evaluating patient health, with gait speed often termed the ”sixth vital sign.” Traditional methods of gait analysis, like observing patients during clinical visits or using motion c...

On-Demand, Efficient Non-Thermal Plasma Biofuel Generator and Method of Use

technology@sc.edu — Tue, 17 Feb 2026 11:18:45 GMT

Reference #: 1753 The University of South Carolina is offering licensing opportunities for On-Demand, Efficient Non-Thermal Plasma Biofuel Generator and Method of Use. Background: Existing methods for biomass conversion, such as pyrolysis or gasification, often require high temperatures, high pressures, expensive catalysts, and significant energy inputs, making them inefficient, expensive, and environmentally taxing. Additionally, many processes depend on fossil-based resources, further exacerbating carbon emissions and limiting sustainability. Invention Description: The invention introdu...

Process Isolating Factors Influencing Treatment Effectiveness from Electronic Medical Records

technology@sc.edu — Tue, 17 Feb 2026 11:11:24 GMT

Reference #: 1745 The University of South Carolina is offering licensing opportunities for Process for Isolating Factors Influencing Treatment Effectiveness from Electronic Medical Records Background: Musculoskeletal (MSK) conditions affect more than half of the U.S. population and account for 1 in 5 healthcare visits. MSK care annual costs exceed $176 billion in direct and $876 billion in indirect healthcare costs and increasing annually. Yet, there is remarkably little evidence across MSK conditions to support treatment decision making. In addition, it is acknowledgement throughout ...

SORPTION ENHANCED AMMONIA PRODUCTION

technology@sc.edu — Tue, 17 Feb 2026 11:07:18 GMT

Reference #: 1737 The University of South Carolina is offering licensing opportunities for Sorption Enhanced Ammonia Production. Background: Ammonia has long been an essential raw material for the manufacture of chemical compounds of vital importance. The demand for this chemical compound is increasing day by day because of its wide variety of use in the industry including power plants, fertilizer production, chemicals synthesis, fibers and plastics, pharmaceutical drugs, mining and metallurgy, and in industrial and household cleaning agents. In the conventional method for producing ammon...

Impact energy assessment through data fusion

technology@sc.edu — Tue, 17 Feb 2026 11:03:55 GMT

Reference #: 1733 The University of South Carolina is offering licensing opportunities for Impact energy assessment through data fusion. Background: When a material is subjected to external forces or internal stress, its internal structure gradually accumulates energy. In composite materials, for example, this process can result in fiber breakage and matrix crack initiation. When the local energy accumulation exceeds the material strength, instantaneous damage occurs, such as crack formation or propagation. The released energy is transformed into stress waves. These waves propagate at a ce...

An Optical Method for Measuring Intracellular Flow

technology@sc.edu — Tue, 17 Feb 2026 10:57:51 GMT

Reference #: 1723 The University of South Carolina is offering licensing opportunities for An Optical Method for Measuring Intracellular Flow. Background: Intracellular flow is caused by fluid transport through (but not limited to) cell membrane proteins, including aquaporin channels, ion channels, stimulation, and cytoplasm streaming. Aquaporins are membrane proteins, e.g. ion channels, that allow the penetration of water across cell-membranes and play a pivotal role in the homeostasis of water in various tissues and organs. Aquaporins are expressed in numerous endothelia, epithelia, and o...

Design and structures of high-speed interconnects for improved signal integrity

technology@sc.edu — Tue, 17 Feb 2026 10:54:20 GMT

Reference #: 1713 The University of South Carolina is offering licensing opportunities for Design and structures of high-speed interconnects for improved signal integrity. Background: In recent years, significant advances in processing techniques have propelled the development of devices with heightened complexity, facilitating the integration of greater amounts of logics and transistors onto miniaturized integrated circuits and chips, which instigate a discernible trend towards increasing densities on printed circuit boards (PCB) and silicon dies, aimed at pursuing systems featuring with h...

Assessment of impact localization and energy

technology@sc.edu — Tue, 17 Feb 2026 10:50:12 GMT

Reference #: 1711 The University of South Carolina is offering licensing opportunities for Assessment of impact localization and energy. Background: When a material is subjected to external forces or internal stress, its internal structure gradually accumulates energy. In composite materials, for example, this process can result in fiber breakage and matrix crack initiation. When the local energy accumulation exceeds the material strength, instantaneous damage occurs, such as crack formation or propagation. The released energy is transformed into stress waves. These waves propagate at a cer...

Gas Turbine Engine Lifecycle Digital-Twin Design, Monitoring and Maintenance

technology@sc.edu — Tue, 17 Feb 2026 10:45:14 GMT

Reference #: 1691 The University of South Carolina is offering licensing opportunities for Gas Turbine Engine Lifecycle Digital-Twin Design, Monitoring and Maintenance. Background: Gas Turbine Engines (GTE) play a significant role in aircraft propulsion and power generation. Increase in GTE efficiency of even 1% can lead to lowering the carbon footprint per unit of electricity generated while saving over $1 billion in fuel cost savings over a ten-year period in the US and thus, keeping the maintenance cost and capital costs lower. The conventional Gas Turbine Engine Development and Monito...

Asymmetric BMOCZ for CFO-resilient Non-coherent Communication

technology@sc.edu — Tue, 17 Feb 2026 10:41:39 GMT

Reference #: 1767 The University of South Carolina is offering licensing opportunities for Asymmetric BMOCZ for CFO-resilient Non-coherent Communication. Background: Non-coherent communication is a promising solution to reduce the overhead in modern wireless systems, particularly for low-latency and short-packet applications. Binary modulation on conjugate-reciprocal zeros (BMOCZ) is an emerging non-coherent digital modulation that works by transmitting the coefficients of a polynomial whose zeros encode information bits. In the absence of noise, the zero structure of the transmitted polyno...

The Optimal Radius and Subcarrier Mapping for BMOCZ

technology@sc.edu — Tue, 17 Feb 2026 10:28:27 GMT

Reference #: 1717 The University of South Carolina is offering licensing opportunities for The Optimal Radius and Subcarrier Mapping for BMOCZ. Background: Non-coherent communication is a promising solution to reduce the overhead in modern wireless systems, particularly for low-latency and short-packet applications. Binary modulation on conjugate-reciprocal zeros (BMOCZ) is an emerging non-coherent digital modulation that works by transmitting the coefficients of a polynomial whose zeros encode information bits. In the absence of noise, the zero structure of the transmitted polynomial is pr...

Noncontact inspection and detection of stress corrosion cracking defect

technology@sc.edu — Tue, 17 Feb 2026 10:24:06 GMT

Reference #: 1743 The University of South Carolina is offering licensing opportunities for Noncontact inspection and detection of stress corrosion cracking defect. Background: Stress corrosion cracking has been observed in the high-level nuclear waste tanks that were constructed by welding carbon steel plates. This cracking presents a safety concern for nuclear spent fuel storage, as nuclear waste can leak out of the tank and pollute the environment. Such cracks may be hard to detect, especially due to the presence of the nuclear waste material inside the structure. Therefore, a method is n...

Immiscible-Multilayer Battery Electrode Architecture

technology@sc.edu — Tue, 17 Feb 2026 10:15:03 GMT

Reference #: 1738 The University of South Carolina is offering licensing opportunities for Immiscible-Multilayer Battery Electrode Architecture. Background: Battery electrodes undergo volumetric expansion and contraction during electrochemical cycling. While this effect is modest in intercalation-based electrodes such as layered transition-metal oxides, it becomes significantly more pronounced in conversion- and alloying-type electrodes, including sulfur cathodes and silicon anodes. Repeated volume changes can lead to cracking, fracturing, delamination from the current collector, and impair...

Electrochemical isotope separation apparatus and uses thereof

technology@sc.edu — Tue, 17 Feb 2026 10:10:50 GMT

Reference #: 1740 The University of South Carolina is offering licensing opportunities for Electrochemical isotope separation apparatus and uses thereof. Background: As science and technology progress, the demand for valuable isotopes like deuterium, lithium-6, and uranium-235 has surged. Separating isotopes of the same element remains technically challenging due to their nearly identical chemical and physical properties, limiting the economic feasibility of many separation approaches. For instance, current uranium isotope separation technologies include gaseous diffusion, gas centrifugat...

Autonomous Railroad Intrusion Detection System with UAV imagery

technology@sc.edu — Tue, 17 Feb 2026 10:04:46 GMT

Reference #: 1760 The University of South Carolina is offering licensing opportunities for Autonomous Railroad Intrusion Detection System with UAV imagery. Background: Accidental intrusions at railway crossings pose a significant threat to railroad safety. According to the Federal Railroad Administration (FRA), 2,147 railroad crossing accidents were reported in 2021, leading to 236 deaths and 666 injuries. Over the years, substantial efforts have been made to improve rail crossing safety through measures such as gated barriers, enhanced road signs, traffic warning lights, and surveillance c...

UV responsivity in self-biased diamond/4H-SiC heterojunction Schottky diodes

technology@sc.edu — Tue, 17 Feb 2026 10:00:27 GMT

Reference #: 1714 The University of South Carolina is offering licensing opportunities for UV responsivity in self-biased diamond/4H-SiC heterojunction Schottky diodes. Background: The increasing demand for robust, efficient, and reliable detection systems in harsh environments, such as those found in nuclear applications and medical imaging, has necessitated the exploration of advanced materials and technologies. Among these, the 4H-SiC (silicon carbide) epilayer-based detector emerges as a promising alternative to traditional Silicon Photomultiplier (SiPM) and Photomultiplier Tube (PMT) s...

Methods for Majority Vote Computation with Modulation on Conjugate-Reciprocal Zeros

technology@sc.edu — Tue, 17 Feb 2026 09:56:16 GMT

Reference #: 1707 The University of South Carolina is offering licensing opportunities for Methods for Over-the-air Computation with Modulation on Conjugate-Reciprocal Zeros. Background: Over-the-air computation (OAC) refers to the computation of special functions like arithmetic mean, norm, polynomial function, maximum, and majority vote (MV) by harnessing the signal superposition property of wireless multiple-access channels. With OAC, instead of acquiring information from each device independently, the transmitters’ signals are intentionally overlapped on the same time-frequency re...

ML-Based Zero-Constellation Design for BMOCZ

technology@sc.edu — Tue, 17 Feb 2026 09:49:31 GMT

Reference #: 1757 The University of South Carolina is offering licensing opportunities for ML-Based Zero-Constellation Design for BMOCZ. Background: Binary modulation on conjugate-reciprocal zeros (BMOCZ) is a modulation scheme, which works by encoding message bits onto the zeros of a polynomial and letting the coefficients of this polynomial modulate a carrier. Within the last decade, non-coherent communication schemes have gained traction for their ability to scale with the dramatic increase in wireless connectivity anticipated with the emergence of the Internet-of-Things (IoT). Binary mo...

Online Training of KAN Autoencoder for Energy Efficient Channel Coding

technology@sc.edu — Tue, 17 Feb 2026 09:45:57 GMT

Reference #: 1747 The University of South Carolina is offering licensing opportunities for Online Training of KAN Autoencoder for Energy Efficient Channel Coding. Background: The AI-native radios using autoencoders along with traditional neural network structures (e.g., multi-layer perceptron (MLP)) to encode and decode information bits face limitations in computational power, memory, and battery life, as traditional neural networks often require a large number of parameters. Kolmogorov-Arnold Networks (KANs) with symbolic regression offer a solution by simplifying learned models into simpl...

Modular Direct Air Capture (DAC) of CO2 using waste materials

technology@sc.edu — Tue, 17 Feb 2026 09:38:49 GMT

Reference #: 1704 The University of South Carolina is offering licensing opportunities for Modular Direct Air Capture (DAC) of CO2 using waste materials. Background: Human activities, mainly burning fossil fuels, have increased greenhouse gas concentrations. Carbon dioxide (CO2) is one of the most abundant greenhouse gases released into the atmosphere. Even though natural processes maintain the CO2 level in the Earth’s atmosphere through the carbon cycle, the atmospheric CO2 level is increasing rapidly. Therefore, there is a pressing need to develop cost-effective and efficient CO2 ad...

Arginase Assay Utilizing a Fluorometric-Based Coupled Enzyme System

technology@sc.edu — Tue, 17 Feb 2026 08:14:32 GMT

Reference #: 1752 The University of South Carolina is offering licensing opportunities for Arginase Assay Utilizing a Fluorometric-Based Coupled Enzyme System. Background: The enzyme arginase is typically assayed for activity by either colorimetry, fluorimetry, or detecting for the concentration of radiolabeled isotopes. In most of the methodologies that are available, high-throughput screening for the evaluation of potent arginase inhibitors is limited. The traditional assays have poor suitability for rapid, automated high-throughput screening of large compound libraries. ...

Engineered peptides by machine learning for cell osteogenic differentiation

technology@sc.edu — Tue, 17 Feb 2026 08:06:56 GMT

Reference #: 1759 The University of South Carolina is offering licensing opportunities for Engineered peptides by machine learning for cell osteogenic differentiation. Background: Resorbable materials loaded with bone morphogenetic proteins (BMPs) are used clinically as a regenerative alternative to autologous bone transplantation for treating skeletal defects to restore continuity. The BMP induces migration of progenitor cells from the surrounding tissue to the injury site followed by their differentiation to pre-osteoblasts and bone morphogenesis. The resorption of the graft concurrent wi...

Novel Intracellular IL-1 Inhibitors for Treating Cancer and Immune Diseases

technology@sc.edu — Tue, 17 Feb 2026 07:58:52 GMT

Reference #: 1761 The University of South Carolina is offering licensing opportunities for Novel Intracellular IL-1α Inhibitors for Treating Cancer and Immune Diseases. Background: Interleukin-1α (IL-1α) is a key cytokine that plays a crucial role in immune system regulation. Dysregulation of IL-1α has been implicated in various chronic diseases, including cancer, rheumatoid arthritis, inflammatory bowel disease, diabetes, Alzheimer’s disease, and sepsis. While IL-1α neutralizing antibodies have demonstrated moderate success in preclinical studies, clinic...

Self-Cooling Multiferroic Magnetic Material for Power Conversion

technology@sc.edu — Tue, 17 Feb 2026 07:54:58 GMT

Reference #: 1764 The University of South Carolina is offering licensing opportunities for Self-Cooling Multiferroic Magnetic Material for Power Conversion. Background: Power electronic converters contain magnetic components which are large portions (>30%) of the volume and weight of the converter. Higher frequencies for power converters can reduce the overall size, but the magnetic components in the MHz range are limited and have poorer outcomes than at lower frequencies. However, semiconductor research is developing Ultra-Wide Bandgap devices which can switch at much higher frequencies...

Semi-automated, dynamic system with mechanical feedback for intra-myocardial injection

technology@sc.edu — Tue, 17 Feb 2026 07:45:53 GMT

Reference #: 1698 The University of South Carolina is offering licensing opportunities for Semi-automated, dynamic system with mechanical feedback for intra-myocardial injection. Background: Current methods of payload (biomaterial/drug/cell) delivery to injured or diseased cardiac tissue (myocardium) involve invasive (e.g. open heart) surgery that can lead to complications and long recovery times. Additionally, the payload is typically delivered manually without much accuracy or precision on depth, location, or quantity. Invention Description: This invention is a minimally invasive, fully...

Cost-effective efficient catalyst for ammonia synthesis

technology@sc.edu — Tue, 17 Feb 2026 07:40:15 GMT

Reference #: 1724 The University of South Carolina is offering licensing opportunities for Cost-effective efficient catalyst for ammonia synthesis. Background: Ammonia is one of the highly produced chemicals that requires high temperatures and pressures for synthesis, consuming 1–2% of the world's energy and contributing 1.8% of global CO2 emissions. To reduce the energy requirements and CO2 emissions, ruthenium-based catalysts can be used. The activity of these catalysts depends on the support used for catalyst synthesis. Rare earth metal oxides are considered as efficient suppor...

Probabilistic Estimation of Gait Parameters Using Floor Vibrations

technology@sc.edu — Wed, 11 Feb 2026 10:48:43 GMT

Reference #: 1725 The University of South Carolina is offering licensing opportunities for Probabilistic Estimation of Gait Parameters Using Floor Vibrations. Background: Walking parameters are demonstrated to provide insights into a person's health status. Gait parameters can be estimated using wearables such as the Apple Watch. However, these devices are not appropriate for certain populations, such as patients with cognitive decline, because they often forget to wear or charge their devices. Invention Description: This technology estimates gait speed and cadence, which are two gait...

NOVEL FILTERS FOR IMAGE GRADIENT COMPUTATION AND EDGE DETECTION

technology@sc.edu — Wed, 11 Feb 2026 09:33:17 GMT

Reference #: 1700 The University of South Carolina is offering licensing opportunities for Novel filters for image gradient computation and edge detection. Background: Gradient computation and edge determination are challenging yet crucial steps in many computer vision tasks. They are the first in multi-step processes, serving as the foundation for all subsequent operations. Their accuracy directly affects the success of any future processing techniques and final detection. The challenge of edge detection is derived from a variety of factors, including noise, image sharpness, orientation, e...

A low-cost indoor positioning system for robotics research and education

technology@sc.edu — Wed, 11 Feb 2026 09:27:07 GMT

Reference #: 1705 The University of South Carolina is offering licensing opportunities for A low-cost indoor positioning system for robotics research and education. Background: Mobile robots are widely used in robotics research, education, and competition. Many applications require accurate, real-time knowledge of a robot’s position to support positioning, navigation, and control. While commercial indoor positioning systems are available and can deliver very high accuracy, they often come with prohibitive costs. In many entry-level university research settings, as well as K–12 e...

Portable Account of Student Skills (PASS)

technology@sc.edu — Fri, 23 Jan 2026 10:55:28 GMT

Reference #: 1746 The University of South Carolina is offering licensing opportunities for Portable Account of Student Skills (PASS). Background: Currently, there is a gap between nursing students and the readiness standard required for practice. Tools for properly evaluating the performance of nursing students in order to project adequate performance in practice are limited. Invention Description: This invention is the PASS evaluation tool. The PASS digital longitudinal scorecard can be used for tracking nursing skills-based competencies throughout their courses at the College of ...

An oxygenating intubating stylet with auditory confirmation of placement

technology@sc.edu — Fri, 23 Jan 2026 10:37:18 GMT

Reference #: 1734 The University of South Carolina is offering licensing opportunities for An oxygenating intubating stylet with auditory confirmation of placement. Background: Suboptimal or inadequate laryngoscopy views are common during endotracheal intubation. First line assistive management during a difficult intubation attempt is to use an intubating stylet to help guide the endotracheal tube successfully through the vocal cords. Intubating stylets currently utilized by medical facilities have drawbacks including desaturation events during prolonged intubation attempts, as well as lack...

Low-cost Ru catalysts for efficient hydrogen production from ammonia decomposition

technology@sc.edu — Fri, 23 Jan 2026 10:27:37 GMT

Reference #: 1727 The University of South Carolina is offering licensing opportunities for Low-cost Ru catalysts for efficient hydrogen production from ammonia decomposition. Background: Hydrogen is a zero-carbon, high-energy-density fuel that holds great promise for replacing fossil fuels in power generation and clean energy applications. Due to the challenges in generating and storing hydrogen for portable applications, ammonia has been proposed as a solution for on-site hydrogen production through ammonia decomposition. At an industrial scale, ammonia is decomposed using nickel supported...

Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications

technology@sc.edu — Mon, 13 Jan 2025 06:42:24 GMT

Reference #: 1742 The University of South Carolina is offering licensing opportunities for Fluorogenic bioconjugation of cyclopropanol-containing fluorophores for biological applications. Background: Fluorophores have been used in various applications of cellular microbiology, most notably with the reporting functions associated with various biological and chemical molecules and compounds. Fluorophores work by absorbing light of a particular wavelength and emitting that same absorbed energy at a slightly longer wavelength (which means the energy emitted is less energetic than the energy abs...

StarTrace: A Multiplex Drug Testing Platform for Personalized Medicine

technology@sc.edu — Thu, 09 Jan 2025 07:37:19 GMT

Reference #: 1744 The University of South Carolina is offering licensing opportunities for StarTrace: A Multiplex Drug Testing Platform for Personalized Medicine Background: The development of cancer treatments tailored to the needs of individual patients is a promising paradigm for oncology. Increased utilization of tumor sequencing illustrates the growing interest in using therapies that specifically target genetic variations in tumors. However, while genetic sequencing has advanced the identification of targetable mutations, only a small percentage of tumors have mutations known to be ac...

A CCL8-based cytotoxic analog for cancer management

technology@sc.edu — Tue, 17 Dec 2024 06:14:13 GMT

Reference #: 1721 The University of South Carolina is offering licensing opportunities for A CCL8-based cytotoxic analog for cancer management. Background: Deregulation of cytokine and chemokine networks is common in various malignancies and other pathologies and has causative role in disease progression. Despite however their acknowledged role in pathology, interference with their activity does not represent a strategy of choice for cancer management because their function is redundant, and their activity is usually mediated by more than one receptor. Thus, disruption of single cytokine/ch...

Nepenthes GDSL Lipase to Treat Gut Lipid Malabsorption and Atrophy

technology@sc.edu — Tue, 17 Dec 2024 06:13:49 GMT

Reference #: 1718 The University of South Carolina is offering licensing opportunities for Nepenthes GDSL Lipase to Treat Gut Lipid Malabsorption and Atrophy. Background: The absorption of dietary lipids in the small intestine is a fundamental biological process central to maintaining energy balances in tissues. Atrophy occurs when the energetic demands of tissues are unmet and can occur as a natural consequence of the aging process or due to cancer and cancer-related treatments. While much consideration is currently focused on development of strategies to reduce fat absorption to combat ob...

Pediatric Cardiac Defect Heart Model

technology@sc.edu — Tue, 17 Dec 2024 06:13:38 GMT

Reference #: 1716 The University of South Carolina is offering licensing opportunities for Pediatric Cardiac Defect Heart Model. Background: To address the current nursing shortage, it is critical to get qualified and well-trained nurses into the profession as quickly as possible without sacrificing quality training. Manipulative anatomy tools are a great way to provide hands-on learning for nurses in training. Invention Description: This invention is a cardiac heart model with interchangeable parts that can be put together to simulate four different cardiac defects (VSD, ASD, PDA, and Te...

Naphthoic Acid-Derived Polymers as Antimicrobial Agents

technology@sc.edu — Tue, 17 Dec 2024 06:12:28 GMT

Reference #: 1710 The University of South Carolina is offering licensing opportunities for Naphthoic Acid-Derived Polymers as Antimicrobial Agents. Background: In the last couple of decades, polymers have been utilized in the medicinal industry into various applications such as drug carriers and substrates, enzyme inhibitors, and preservatives, due to their unique structural versatility, stability, and affordable manufacturing cost. Among various polymer motifs, facially amphiphilic antimicrobial polymers have been considered as promising candidates because of their disruptive ability again...

Novel imidazothiazoles inhibiting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO)

technology@sc.edu — Tue, 17 Dec 2024 06:06:46 GMT

Reference #: 1706 The University of South Carolina is offering licensing opportunities for Novel imidazothiazoles inhibiting indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO). Background: The kynurenine pathway (KP) is involved in the modulation of many biological and physiological processes including immune response and neurotransmission. Overactive KP has been linked to a wide range of diseases and conditions such as cancer, depression, chronic/neuropathic pain, neurodegeneration, HIV immune dysfunction, etc. Regulating PK by inhibiting the activity of IDO1 and TDO...

Aminergic phytocannabinoids derivatives as multi-target agents for Neurological disorders

technology@sc.edu — Fri, 06 Dec 2024 11:10:41 GMT

Reference #: 1729 The University of South Carolina is offering licensing opportunities for Aminergic phytocannabinoids derivatives as multi-target agents for neurological disorders. Background: The medicinal properties of certain aminergic cannabinoid derivatives are currently being explored, but preliminary data shows they may possess potential to act in the brain as anti-depressants, anxiolytics, and/or non-traditional anti-psychotics. Moreover, recent data suggests that these aminergic cannabinoids may exhibit the ability to treat or delay the onset of neurodegenerative conditions. These...

Design of Biosensor with high sensitivity and selectivity

technology@sc.edu — Mon, 02 Dec 2024 12:46:38 GMT

Reference #: 1687 The University of South Carolina is offering licensing opportunities for Design of Biosensor with high sensitivity and selectivity. Background: Biosensors have become a potent tool that is widely used for health care, environmental and food safety monitoring, and all the way for disease diagnostics. The early diagnosis of diseases can enhance preventive measures, increase the curability of the disease, and reduce healthcare costs. Although there are many conventional biosensors, they often suffer challenges in terms of sensitivity, detection time, and expenses. For example...

Predicting biomaterial-implant surgical outcome using medical record and blood-cytokine data

technology@sc.edu — Tue, 19 Nov 2024 11:36:17 GMT

Reference #: 1680 The University of South Carolina is offering licensing opportunities for Predicting biomaterial-implant surgical outcome using medical record and blood-cytokine data. Background: Pelvic organ prolapse (POP), defined as symptomatic descent of the vagina and surrounding pelvic organs, affects approximately 50% of parous women and 6% of nonparous women between ages 20 and 59 years, with almost 300,000 POP surgeries performed per year. To reduce anatomical recurrence, surgical treatment may include the insertion of polypropylene mesh into the vaginal wall to provide mechanical...

Chemical Crosslinking of PVDF Binder for Battery Electrodes

technology@sc.edu — Tue, 19 Nov 2024 11:30:45 GMT

Reference #: 1682 The University of South Carolina is offering licensing opportunities for Chemical Crosslinking of PVDF Binder for Battery Electrodes. Background: Various three-dimensional network structures of crosslinked polymer binders have been developed to improve the electrode structure and cell performance of batteries at high active material loading and low electrolyte usage. However, most of the crosslinked polymer binders are expensive, and stable only in a limited voltage window. Crosslinked PVDF, despite its remarkable electrochemical stability, and low cost, has not been adopt...

Integration of In-Memory Analog Computing Architectures with Tensor Processing Units

technology@sc.edu — Tue, 19 Nov 2024 11:13:11 GMT

Reference #: 1690 The University of South Carolina is offering licensing opportunities for Integration of In-Memory Analog Computing Architectures with Tensor Processing Units. Background: Tensor processing units (TPUs), specialized hardware accelerators for machine learning tasks, have shown significant performance improvements when executing general matrix-matrix multiplication in machine learning models. However, they struggle to maintain the same efficiency for matrix-vector multiplication (MVM) operations, leading to suboptimal hardware utilization. In-memory analog computing (IMAC) a...

Electrochemical ion extraction apparatus comprising ion selective membrane

technology@sc.edu — Mon, 18 Nov 2024 13:34:19 GMT

Reference #: 1686 The University of South Carolina is offering licensing opportunities for Electrochemical ion extraction apparatus comprising ion selective membrane. Background: The present invention relates generally to the field of mining valuable mineral ions from an aqueous phase. Particularly, the present invention describes an electrochemical ion extraction apparatus comprising ion selective membrane and its applications in the field, including but not limited to selective ions extraction from seawater/brine water for valuable minerals production/recycling and isotope separation. Cu...

Waveform-Triggered Reception and Buffering for Millimeter-Wave Software-Defined Radios

technology@sc.edu — Mon, 07 Oct 2024 11:26:57 GMT

Reference #: 01628 The University of South Carolina is offering licensing opportunities for waveform-triggered reception and buffering for millimeter-wave software-defined radios. Background: Millimeter-wave (mmWave) communications is one of the key enablers for high-throughput systems by allowing directive links over a large bandwidth. While there has been extensive research activity for mmWave systems, experimentation in real-world environments is still a major challenge due to the lack of low-cost and portable mmWave software-defined radios (SDRs), as compared to the ones for sub-6 GHz...

Innovative vibrational system for the trunk proprioceptive impairment study

technology@sc.edu — Thu, 26 Sep 2024 08:06:43 GMT

Reference #: 1664 The University of South Carolina is offering licensing opportunities for Innovative vibrational system for the trunk proprioceptive impairment study. Background: One of the key human feedback systems is somatosensory system. The somatosensory system transmits proprioceptive, or body segment position sense, information from sensors in the skin, joints, tendons, and muscles. The human nervous system uses the proprioceptive information to reveal a predictive model of the body’s location in space both relative to itself and the surroundings. Proprioceptive deficits are a...

Cu-Ni fuel cell catalysts for dehydrogenation of methylcyclohexane

technology@sc.edu — Thu, 26 Sep 2024 07:55:27 GMT

Reference #: 1670 The University of South Carolina is offering licensing opportunities for Cu-Ni fuel cell catalysts for dehydrogenation of methylcyclohexane. Background: On-board storage of H2 in a safe format has limited the use of fuel cells in mobile transportation applications. Cylinders of compressed H2 will be difficult to implement due to potential of sudden and uncontrolled release of high pressure H2 gas. The use of a controlled release of H2 from a H2 carrier chemical such as methylcyclohexane (MCH) circumvents this issue. However, H2 release chemicals must use catalysts to effic...

Portable Railroad Grade Crossing Monitoring System

technology@sc.edu — Thu, 26 Sep 2024 07:43:20 GMT

Reference #: 1676 The University of South Carolina is offering licensing opportunities for Portable Railroad Grade Crossing Monitoring System. Background: Every year, a significant number of accidents occur at railroad crossings, involving collisions between trains and pedestrians, vehicles, or other obstacles. Whether due to intentional actions or inadvertent mistakes, pedestrians and vehicles often find themselves in the high-risk zone of the grade crossing. By the time a train operator is able to detect these obstructions, it is generally too late to halt the train safely. Invention Des...

Neural repair through inhibition of Reg3A signaling

technology@sc.edu — Wed, 18 Sep 2024 06:34:18 GMT

Reference #: 1677 The University of South Carolina is offering licensing opportunities for Neural repair through inhibition of Reg3A signaling. Background: Human peripheral nerve regeneration is rarely successful when the nerve's axons must regrow more than 5-6 cm. By the time the regenerating axons in the nerve get past 5-6 cm, the environment no longer supports growth and target tissues are no longer receptive for reinnervation. Invention Description: This invention has identified a signaling pathway that slows regeneration through the promotion of mRNA degradation. Blocking this p...

Engineering Immune Responses with Programmable Transcription Factors

technology@sc.edu — Wed, 18 Sep 2024 06:27:54 GMT

Reference #: 1699 The University of South Carolina is offering licensing opportunities for Engineering Immune Responses with Programmable Transcription Factors. Background: The regulation immune activation pathways are the bedrock of immunotherapy treatments for cancer and infectious diseases. Strategies for activation typically include administering molecular adjuvants or other inflammatory cues composed of salt or oil emulsion mixtures, oligonucleotides, or lipids, which ultimately promote transcription and translation of inflammasome genes. These strategies are used widely across immuno...

Fluidic control system for repeat analysis of individual particles

technology@sc.edu — Mon, 29 Jul 2024 06:59:07 GMT

Reference #: 1709 The University of South Carolina is offering licensing opportunities for Fluidic Control System for Repeat Analysis of Individual Particles Background: Cytometry is the study of cellular/particle characteristics in a controlled environment by subjecting them to multiple tests/treatments in order to classify and distinguish them. Such methods include, fluorescence, absorption, light scattering, etc. Invention Description: This system is a system for isolating individual particles and controlling their position, allowing for repeat measurements of the same particle as well...

Lignin-based Adhesives using Silyl Ether Hardeners and Thiol-ene Chemistry

technology@sc.edu — Mon, 29 Jul 2024 06:48:48 GMT

Reference #: 1683 The University of South Carolina is offering licensing opportunities for Lignin-based Adhesives using Silyl Ether Hardeners and Thiol-ene Chemistry. Background: Modern adhesives, such as epoxy resins or latex, offer high adhesion strength on a diverse range of substrates. However, the feedstocks for the manufacturing of these materials are often fossil fuels that are increasingly unsustainable and undesirable for environments therefore greener adhesives are required. Lignin is a renewable feedstock that is abundant and inexpensive but still presents challenges for its valo...

Using Infrared Technology to Detect Tissue Damage Below the Skin

technology@sc.edu — Mon, 29 Jul 2024 06:45:25 GMT

Reference #: 01648 The University of South Carolina is offering licensing opportunities for Using Infrared Technology to Detect Tissue Damage Below the Skin. Background: Thermography is a technique that can measure variations in skin temperature, which often indicates underlying damage. The use of artificial intelligence enables precise and consistent monitoring of these temperature changes over time, identifying early signs of damage and allowing for preventative treatment, improving the overall health and wellbeing of patients. Invention Description: This innovation combines infrared th...

An amino acid hybrid of aCGRP to treat cardiovascular disease

technology@sc.edu — Mon, 29 Jul 2024 06:41:36 GMT

Reference #: 01645 The University of South Carolina is offering licensing opportunities for An Amino Acid Hybrid of a CGRP to Treat Cardiovascular Disease. Background: Heart failure is a chronic condition affecting millions of people worldwide, often leading to reduced lifespan and poor quality of life. The American Heart Association (AHA) estimates that by 2035, 45.1% of the US population would have some form of cardiovascular disease (CVD). This predicted growth only heightens the already pervasive need for successful CVD treatments. Invention Description:&n...

Metal oxide-metal catalysts using differential surface free energies

technology@sc.edu — Thu, 11 Jul 2024 06:48:35 GMT

Reference #: 1669 The University of South Carolina is offering licensing opportunities for Metal oxide-metal catalysts using differential surface free energies. Background: One of the biggest problems with the manufacture of catalysts with multiple components is to position all of the components in proximal position in order to utilize the synergistic properties that result from cooperative interaction of the different components. The technology described in this disclosure uses thermodynamics, one of the basic forces of science and nature to drive the formation of multi-component catalysts...

All Weather Traffic Monitoring with Roadside Infrastructure

technology@sc.edu — Tue, 25 Jun 2024 12:08:18 GMT

Reference #: 1666 The University of South Carolina is offering licensing opportunities for All Weather Traffic Monitoring with Roadside Infrastructure. Background: In 2021, a staggering 7,500 pedestrian fatalities were reported in the United States as a result of vehicular collisions. According to the US Department of Transportation, over 50% of fatal or injurious road accidents occur at or in close proximity to traffic intersections. Most, if not all, of these deaths and injuries can be prevented by proactively warning the drivers, vehicles, and pedestrians; for example, by notifying the p...

Microwave Process to Prepare Crystalline Anhydrous Monazite-Type Materials

technology@sc.edu — Thu, 20 Jun 2024 12:26:15 GMT

Reference #: 1697 The University of South Carolina is offering licensing opportunities for Microwave Process to Prepare Crystalline Anhydrous Monazite-Type Materials. Background: Rhabdophane and Monazite are naturally occurring minerals that contain varying amounts of different lanthanides and in some cases thorium and uranium. Rhabdophane, a hydrated low temperature form, can be converted to Monazite via high temperature ~1000 °C heat treatment, which proceeds via several stages of dehydration prior to the structure transition. Monazite has applications in nuclear waste forms due to it...

Wordification

technology@sc.edu — Thu, 13 Jun 2024 09:57:11 GMT

Reference #: 1693 The University of South Carolina is offering licensing opportunities for Wordification. Background: Typical spelling instruction is largely memory based and ineffective for students who need the most help. Teacher training programs for more effective instruction exist but cost $3000-4000 per instructor. Students with different backgrounds and abilities need spelling instruction that is individualized and paced according to their needs. However, there are few resources and little class time for providing individualized instruction. Individualized tutoring is available but, ...

Cyclopropanol as a bioorthogonal warhead for electrochemically controlled bioconjugation applications

technology@sc.edu — Wed, 12 Jun 2024 10:13:40 GMT

Reference #: 1685 The University of South Carolina is offering licensing opportunities for Cyclopropanol as a bioorthogonal warhead for electrochemically controlled bioconjugation applications. Background: Bioconjugation techniques play an important role in modern chemical biology and biomedical sciences, such as protein drug stabilization, target therapy, and the development of antibody-drug conjugates, etc. Typically, biorthogonality is required for an effective in situ bioconjugation reaction, which enables the selective and non-disruptive labeling and manipulation of biomolecules within...

Core-shell SDAs

technology@sc.edu — Wed, 12 Jun 2024 10:04:04 GMT

Reference #: 1679 The University of South Carolina is offering licensing opportunities for Core-shell SDAs. Background: Nanocomposites can exhibit characteristics superior to that of their individual components. Nature has evolved ways to control the architecture and placement of multiple materials elegantly through biomineralization of nanoparticles (NP), however, bottom-up nanocomposite synthesis remains limited. Inorganic nanocomposites from structure directing agents (SDAs) and multiple NP-types are normally limited to random NP-mixtures. Invention Description: This process enables a ...

Novel treatment for pseudomyxoma peritonei

technology@sc.edu — Tue, 11 Jun 2024 09:58:03 GMT

Reference #: 1692 The University of South Carolina is offering licensing opportunities for Novel treatment for pseudomyxoma peritonei. Background: Pseudomyxoma peritonei (PMP) is a rare cancer, which originates as an appendiceal neoplasm. Due to its usually poor vascularization and floating as nodules, PMP spreads easily to the peritoneal cavity, causing mucinous ascites and tumor implants on the surfaces of the peritoneal wall and abdominal organ surfaces. Due to the limited effectiveness of current chemotherapy drugs against PMP, the standard treatment involves a high-risk, intensive surg...

Immunomodulating Activities of Alistipes and Its Metabolites: Mechanism and Application

technology@sc.edu — Tue, 11 Jun 2024 09:50:30 GMT

Reference #: 1678 The University of South Carolina is offering licensing opportunities for Immunomodulating Activities of Alistipes and Its Metabolites: Mechanism and Application. Background: The gut microbiota plays a key role in health and disease. The balance between beneficial genera (such as Alistipes and Odoribacter) and harmful species (such as Escherichia coli) dictates the gut health as well as the overall health of an individual. However, the underlying mechanisms are largely unknown, and only very limited scientific discoveries in this regard have been reduced to clinical practic...

Nepenthes prolyl endopeptidases to suppress gluten sensitivity in humans

technology@sc.edu — Tue, 11 Jun 2024 09:43:01 GMT

Reference #: 1673 The University of South Carolina is offering licensing opportunities for Nepenthes prolyl endopeptidases to suppress gluten sensitivity in humans. Background: It is currently estimated that 5% of the world's population suffers from gluten-related disorders, though this number is considered a gross underestimate due to the difficulties of accurately diagnosing such patients. Additionally, the incidence of gluten-related disorders is increasing, and will continue to do so, due to the increasing reliance on grains to sustain the world’s population. The gold-standard...

Methods for wireless unsupervised federated clustering with over-the-air computation

technology@sc.edu — Tue, 21 May 2024 09:38:01 GMT

Reference #: The University of South Carolina is offering licensing opportunities for Methods for wireless unsupervised federated clustering with over-the-air computation. Background: Over-the-air computation (OAC) is a physical layer concept that can benefit a wide variety of applications for function computation over a bandwidth-limited wireless channel by reducing resource utilization to a one-time cost that does not scale with the number of edge devices (EDs). It exploits the signal superposition property of wireless multiple-access channels to compute a set of special mathematical func...

Drug repurposing for treatment of congenital vascular malformations

technology@sc.edu — Fri, 17 May 2024 08:14:51 GMT

Reference #: 1659 The University of South Carolina is offering licensing opportunities for Drug Repurposing for Treatment of Congenital Vascular Malformations. Background: Congenital vascular malformations (CVM) are a major threat to public health with a 1.5% incident rate in the general population. Congenital capillary malformation (CM), a.k.a., port-wine birthmarks or stains (PWB or PWS), are the most common type of CVM with an estimated prevalence of 0.3–0.5% per live births. The pulsed dye laser (PDL) or photodynamic therapy (PDT) is the treatment of choice for PWB. The current la...

In-Situ Beta-particle detector for High Resolution 234Th Export Measurements

technology@sc.edu — Fri, 17 May 2024 08:11:06 GMT

Reference #: 01654 The University of South Carolina is offering licensing opportunities for In-Situ Beta-particle Detector for High Resolution 234Th Export Measurements. Background: Thorium-234 (234Th) levels serve as a crucial indicator of carbon sequestration from the ocean surface. Measuring 234Th activity in ocean-settling particles can be used to evaluate the effects of climate change. Invention Description: This invention is an innovative marine instrument designed to accurately measure 234Th activity in ocean-settling particles, serving as a crucial indicator of carbon sequestratio...

Trigonelline mitigates cardiomyopathy caused by SARS-CoV-2 Spike protein under obesity

technology@sc.edu — Fri, 17 May 2024 08:03:36 GMT

Reference #: 01642 The University of South Carolina is offering licensing opportunities for Trigonelline mitigates cardiomyopathy caused by SARS-CoV-2 spike protein under obesity. Background: Today, the spread of Coronavirus Disease 2019 (COVID-19) continues, and while millions of patients have recovered, a significant number experience prolonged illness known as long COVID. This condition poses a major challenge for doctors, particularly as many long COVID patients develop heart problems. Invention Description: We can show that spike proteins from the SARS-CoV-2 can damage a place in he...

Using EEG to predict delirium using limited lead device

technology@sc.edu — Fri, 17 May 2024 07:58:50 GMT

Reference #: 01627 The University of South Carolina is offering licensing opportunities for Using EEG to predict delirium using limited lead device. Background: This study demonstrates a machine learning-based approach to detect delirium using limited lead EEG data with a high accuracy of 98% prior to the onset of clinical symptoms. In contrast to the current bedside clinical screening method, which relies on patient participation, this approach enables non-invasive detection of delirium in patients who may not be able to participate in the assessment. Invention Description: This innovati...

MXene-based 3D printable conductive ink, preparation method and applications thereof

technology@sc.edu — Thu, 09 May 2024 07:24:31 GMT

Reference #: 01661 The University of South Carolina is offering licensing opportunities for MXene-based 3D printable conductive ink, preparation method and applications thereof. Background: This innovation involves a new method to create a special type of ink that can be used in 3D printing processes. This ink, made from a Titanium carbide (Ti3C2Tx) MXene, allows the production of objects that are not only lightweight and strong but also exhibit excellent electrical and electronic properties, making them ideal for use in electronics. These could include parts for smart devices that require ...

Portable Railroad Track Component Inspection System (no patent reimbursement in license)

technology@sc.edu — Mon, 06 May 2024 12:21:59 GMT

Reference #: 01660 The University of South Carolina is offering licensing opportunities for Potable Railroad Track Component Inspection System Background: The Federal Railroad Administration (FRA) stipulates routine track inspections to maintain railroad safety and efficiency. However, conventional manual inspections are not only inefficient and prone to errors but also lack precision. Even though automated technologies have been introduced across various engineering applications, these too carry their own set of limitations. Current railroad inspection tools, such as GPR, laser, LiDAR, an...

A novel formulation of nutraceutical compounds--PHMHP

technology@sc.edu — Fri, 26 Apr 2024 07:43:20 GMT

Reference #: 1665 The University of South Carolina is offering licensing opportunities for A novel formulation of nutraceutical compounds--PHMHP. Background: Natural compounds such as quercetin and emodin hold a great promise to be developed as therapeutic agents for various diseases such as cancer, cardiovascular disease, Alzheimer’s disease, inflammatory bowel diseases, and fibrotic diseases. However, they have not been approved by U.S. Food and Drug Administration (FDA) for any clinical applications. This is largely due to their low water solubility and low bioavailability. Invent...

Therapeutic gossypol-based inhibitors of glucose kinases for parasitic diseases

technology@sc.edu — Fri, 26 Apr 2024 06:20:58 GMT

Reference #: 01658 The University of South Carolina is offering licensing opportunities for therapeutic gossypol-based inhibitors of glucose kinases for parasitic diseases. Background: Trypanosoma cruzi and Trypanosoma brucei, which are protozoan parasites pathogenic to the human host are the etiological agents of Chagas' disease and human African trypanosomiasis, respectively. These trypanosomatid parasites individually depend on glycolysis, the pentose phosphate pathway, and gluconeogenesis for their survival. The metabolite D-glucose-6-phosphate (G6P) is at a nodal point ...

Retinol Acid Pathway Modulators for Treatment of Congenital Vascular Malformation

technology@sc.edu — Wed, 24 Apr 2024 08:47:44 GMT

Reference #: 01657 The University of South Carolina is offering licensing opportunities for Retinol Acid Pathway Modulators for Treatment of Congenital Vascular Malformation. Background: Congenital vascular malformations (CVM) are a major threat to public health with a 1.5% incident rate in the general population. Congenital capillary malformation (CM), a.k.a., port-wine birthmarks or stains (PWB or PWS), are the most common type of CVM with an estimated prevalence of 0.3–0.5% per live births. The pulsed dye laser (PDL) or photodynamic therapy (PDT) is the treatment of choice for PWB....

Cannabis Plant Material as an Agent for Mitigating Metabolic Syndrome

technology@sc.edu — Wed, 24 Apr 2024 07:32:44 GMT

Reference #: 01640 The University of South Carolina is offering licensing opportunities for Cannabis Plant Material as an Agent for Mitigating Metabolic Syndrome. Background: A symptom of metabolic syndrome is insulin resistance, defined as the inability of insulin to optimally stimulate the transport of glucose into the body’s cell (hyperinsulinemia or impaired glucose tolerance). This can lead to type II Diabetes and Cardiovascular Disease. The research done has discovered that the Cannabis Plant Material can reduce fasting glucose and insulin and lower the homeostasis model assessm...

Enzyme Immobilization on Delignified Bamboo Scaffolds as a Multienzyme Bioreactor

technology@sc.edu — Mon, 01 Apr 2024 06:43:14 GMT

Reference #: 01643 The University of South Carolina is offering licensing opportunities for Enzyme Immobilization on Delignified Bamboo Scaffolds as a Multienzyme Bioreactor. Background: Enzymes are used in a multitude of industries as catalysts for production. Though enzymes have many advantages they can often be more costly than other catalyst materials and be less stable. Multi-enzyme immobilization can be used to improve the stability of enzymes and potentially make using them more cost effective. Invention Description: A multi-enzyme immobilization system was developed using deligni...

Sleep Disruptions Identification from Millimeter-Wave Wireless Systems

technology@sc.edu — Tue, 05 Mar 2024 07:52:25 GMT

Reference #: 01651 The University of South Carolina is offering licensing opportunities for Sleep Disruptions Identification from Millimeter-Wave Wireless Systems. Background: Millimeter-wave (mmWave) wireless-based solutions can enable fine-grained disruption monitoring from wireless signal reflections. The core idea is to leverage cross-correlation between successive mmWave reflected signals and a Hidden Markov Model (HMM) to identify the sleep disruptions, such as toss-turn patterns, to provide insight into the impact of sleep on the overall functioning of adults and future cognitive dev...

Assigning Trust Rating to AI Services Using Causal Impact Analysis

technology@sc.edu — Tue, 26 Sep 2023 10:04:47 GMT

Reference #: 01617 The University of South Carolina is offering licensing opportunities for Assigning Trust Rating to AI Services Using Causal Impact Analysis Background: Today, it is very difficult for an AI user to know what the AI service is doing. This leads to users not trusting AI and most developers, who are genuine users and reuse others’ APIs or data, becoming open to liability and risk. Invention Description: Our method assigns a label (rating) to AI services in a black-box setting that conveys their behavior related to the trust/reliability of the services. We generate ...

In-situ deposition of oxide passivation layer on III-Nitride based HEMT

technology@sc.edu — Mon, 10 Apr 2023 08:02:42 GMT

Reference #: 01623 The University of South Carolina is offering licensing opportunities for in-situ deposition of oxide passivation layer on III-Nitride based HEMT Background: The passivation layers on III-Nitride-based high electron mobility transistors (HEMTs) are essential for realizing high breakdown voltage and low leakage current applications. This innovation describes a method to achieve low interfacial charge density by in-situ gate oxide-dielectric deposition on III-Nitride-based HEMT structures grown in the same reactor. The method may include the growth of the complete device str...

DAPHNIA GAMES Playing Cards Set

technology@sc.edu — Tue, 29 Nov 2022 09:40:15 GMT

Reference #: 01592 The University of South Carolina is offering licensing opportunities for the DAPHNIA GAMES aka TAILSPINE role-playing game and card set complete with game pieces Background: The DAPHNIA GAMES aka TAILSPINE is a card-driven, competitive, engine-building game. The game is designed for players to subversively interact with several layers of ecological and evolutionary theory under the premise of a simple and engaging board game. Players start with a population of Daphnia, small freshwater zooplankton, and actively respond to environmental threats by altering the traits of th...

Lithium Sulfur Battery Electrode Process

technology@sc.edu — Fri, 18 Nov 2022 10:17:51 GMT

Reference #: 01598 The University of South Carolina is offering licensing opportunities for Lithium Sulfur Battery Electrode Process Background: Sulfur is a promising candidate for next-generation cathodes in Li battery systems. However, modern Li-S cathodes cannot be extensively cycled. Invention Description: The present innovation provides a simple and low-cost processing method to create electrodes that allow for significantly improved cycling and lifetime. The cyclability of Li-S batteries is improved by developing a new method to make electrodes. The concept involves controlling ho...

Dielectric Barrier Discharge Plasma System for in-situ Hydrogen Peroxide Production

technology@sc.edu — Fri, 18 Nov 2022 09:12:27 GMT

Reference #: 01599 The University of South Carolina is offering licensing opportunities for Dielectric Barrier Discharge Plasma System for in-situ Hydrogen Peroxide Production Background: Most of the hydrogen peroxide (H2O2) vapor generators, which exist in the market merely use flash vaporization of the liquid form of H2O2 to form H2O2 vapor. Some of these generators can only operate in ultra-high vacuum. Other existing generators that produce H2O2 from water employ physical membranes, which are expensive and must be replaced at regular intervals. Invention Description: The device uses...

Misty Plasma Dielectric Barrier Discharge Plasma System for Disinfection

technology@sc.edu — Wed, 16 Nov 2022 11:58:23 GMT

Reference #: 01600 The University of South Carolina is offering licensing opportunities for Misty Plasma Dielectric Barrier Discharge Plasma System for Disinfection Background: Approximately 1.7 million healthcare-associated infections occur each year in the U.S., killing 98,000 patients. COVID-19 has revealed further weaknesses in the preparedness of healthcare facilities, which lacked the ability to adequately disinfect existing personal protective equipment (PPE), exacerbating an already precarious situation. Chemical germicides, UV light, etc. approaches have proven insufficient. Inven...

Facial Recognition Based on Converted Spiking Neural Network

technology@sc.edu — Tue, 15 Nov 2022 09:51:41 GMT

Reference #: 01602 The University of South Carolina is offering licensing opportunities for Facial Recognition Based on Converted Spiking Neural Network Background: The current method for facial recognition requires a lot of computing resources (high-performance computers) which is not portable, and the accuracy is very limited. Invention Description: We developed computer software with an innovative method to recognize the same person from different pictures. So, we can identify who is who based on the photos or videos from different sources. The model we developed is a very efficient mo...

Lebesgue-Sampling-based Deep Learning for Battery Diagnosis and Prognosis

technology@sc.edu — Tue, 15 Nov 2022 08:42:52 GMT

Reference #: 01603 The University of South Carolina is offering licensing opportunities for Lebesgue-Sampling-based Deep Learning for Battery Diagnosis and Prognosis Background: Accurate and efficient modeling of battery degradation is of great challenge and is becoming more and more complex for batteries in modern applications. Traditional degradation modeling methods have difficulty capturing these characteristics, and the FPD performance will be affected. Deep learning algorithms have powerful feature extraction and learning abilities. However, they are not capable of uncertainty manag...

Expandable Drone

technology@sc.edu — Thu, 27 Oct 2022 11:36:38 GMT

Reference #: 01604 The University of South Carolina is offering licensing opportunities for Expandable Drone Background: Although many different styles and designs exist, unmanned aerial vehicles (UAVs), commonly referred to as “drones,” meant for consumer and commercial use typically consist of the main body from which multiple rotor assemblies extend. Usually, the main body contains one or more batteries, a control system, transceivers, sensors, and various hardware. The rotor assemblies (nacelles) usually consist of one or more motors and one or more rotor blades with elect...

The value of microRNA-155 in breast cancer prognosis and treatment

technology@sc.edu — Wed, 26 Oct 2022 12:36:28 GMT

Reference #: 01608 The University of South Carolina is offering licensing opportunities for The value of microRNA-155 in breast cancer prognosis and treatment Background: In the US in 2021, there were an estimated 281,550 new cases of invasive breast cancer diagnosed in women; 2,650 cases diagnosed in men. An estimated 44,130 breast cancer deaths (43,600 women and 530 men) occurred in 2021. Invention Description: A simple measurement of miR-155 content in a patient serum or plasma sample will predict the response of a breast cancer patient to immune therapies. Increasing miR-155 levels i...

Click Chemistry Amplified Nanopore Assay for Ultrasensitive Quantification of Proteins

technology@sc.edu — Wed, 26 Oct 2022 10:21:46 GMT

Reference #: 01610 The University of South Carolina is offering licensing opportunities for Click Chemistry Amplified Nanopore Assay for Ultrasensitive Quantification of Proteins Background: Despite major advances in HIV testing, ultrasensitive detection of early infection remains a key challenge, especially for the viral capsid protein p24, which is recognized as an alternative early virological biomarker of HIV-1 infection. Invention Description: Increasing the accuracy of protein biomarkers (antigen, antibody, etc.) testing at ultralow concentration will allow early diagnosis of many...

Computer Aided Process Planning Software

technology@sc.edu — Mon, 24 Oct 2022 10:07:09 GMT

Reference #: 01611 The University of South Carolina is offering licensing opportunities for Computer Aided Process Planning Software Background: Automated Fiber Placement (AFP) is an additive manufacturing technique using strips of composite material that is employed in the manufacturing of large aerospace structures. The inherent complexity of the process results in unavoidable defect generation that is largely dependent on the geometry of the structure. Process planning is the matchmaking between a design and manufacturing, and proper planning can help to eliminate many predictable defe...

Methods and Procedures for Synchronization and Over-the-Air Computation

technology@sc.edu — Mon, 10 Oct 2022 12:45:46 GMT

Reference #: 01615 The University of South Carolina is offering licensing opportunities for Methods and Procedures for Synchronization and Over-the-Air Computation Background: Over-the-air computation (OAC) reduces the communication latency that linearly increases with the number of devices in a wireless network for machine learning applications. Despite its merit, an OAC scheme may require the radios to start their transmissions synchronously with high accuracy, which can impose stringent requirements for the underlying mechanisms. On the other hand, when software-defined radios (SDRs) a...

Predicting Railroad Ballast Fouling Conditions Based on Ballast Image

technology@sc.edu — Mon, 10 Oct 2022 10:45:47 GMT

Reference #: 01616 The University of South Carolina is offering licensing opportunities for Predicting Railroad Ballast Fouling Conditions Based on Ballast Image Background: Evaluating railway ballast fouling conditions are critical to assessing track conditions and arranging proper ballast maintenance. The fouled ballast affects the performance of the track and can accelerate track deterioration. Hence, regular ballast maintenance activities are required, and the specific maintenance activity selection depends on the fouling severity. To quantify the fouling severity is important to sche...

Upgrading of Bio-Oil Using Ammonia

technology@sc.edu — Wed, 05 Oct 2022 07:00:40 GMT

Reference #: 01619 The University of South Carolina is offering licensing opportunities for Upgrading of Bio-Oil derived from Biomass Using Ammonia Background: Upgrading biomass to bio-coal produces bio-oil- a mixture of carbon-based compounds a...

Multimodal Retrieval and Execution Monitoring Using Rich Recipe Representation

technology@sc.edu — Wed, 14 Sep 2022 10:44:30 GMT

Reference #: 01587 The University of South Carolina is offering licensing opportunities for Multimodal Retrieval and Execution Monitoring Using Rich Recipe Representation Background: The content of recipes like for preparing food or assembling furniture exist as textual or image documents which makes it difficult for machines to read, reason and handle ambiguity. We consider the problem of reasoning with data in recipes in multiple representations. Invention Description: Our innovative representation is used in a web-based decision support system that helps users perform constrained queri...

Abbapolins as Inhibitors and Degraders of Polo-Like Kinases

technology@sc.edu — Wed, 14 Sep 2022 07:16:18 GMT

Reference #: 01593 The University of South Carolina is offering licensing opportunities for Abbapolins as Inhibitors and Degraders of Polo-Like Kinases Background: There are no effective treatments for castration-resistant prostate cancers as all current therapies eventually fail. Invention Description: Novel chemicals called abbapolins are described that block the activity of a protein called Polo Like Kinase 1 essential for cells to grow and divide. These have the potential for further development as drugs for prostate and other cancers that produce high levels of this protein, or which...

Methodology and GUI for NDE/SHM using Two-Stage Compressive Sensing

technology@sc.edu — Wed, 14 Sep 2022 07:03:21 GMT

Reference #: 01579 The University of South Carolina is offering licensing opportunities for Methodology and GUI for NDE/SHM using Two-Stage Compressive Sensing Background: Compressive Sensing has been shown to greatly reduce data acquisition and processing burdens by providing mathematical guarantees for accurate signal recovery from far fewer samples than conventionally needed. NASA is developing new vehicles for human space flight. Many of these spacecraft are targeted for long-term use, which offers challenges for inspection and maintenance. Invention Description: The purpose of the i...

Phospholipid Presenting Particles for Cell Targeting in Therapy and Diagnostics

technology@sc.edu — Tue, 13 Sep 2022 11:39:13 GMT

Reference #: 01594 The University of South Carolina is offering licensing opportunities for Phospholipid Presenting Particles for Cell Targeting in Therapy and Diagnostics Background: Current FDA approved controlled/extended-release formulations based on polyesters such as polylactic acid, poly(lactide-co-glycolide), and polycaprolactone do not benefit from surface functionalization which could enable cell targeting and cell signaling. Invention Description: We have devised a method to alter the surface reactivity of polymer particles widely used in basic science and clinical practice to ...

Hybrid Rotating Machinery Fault Diagnosis and Prognosis

technology@sc.edu — Tue, 13 Sep 2022 11:08:26 GMT

Reference #: 01570 The University of South Carolina is offering licensing opportunities for Hybrid Rotating Machinery Fault Diagnosis and Prognosis Background: Bearing faults are the top contributor to the failure of rotating machinery systems. In wind energy systems, about 80% of gearbox failures are caused by bearing faults. According to verified market report, the global rotating machinery market was valued at USD 1,20,725.2 million in 2018 and is projected to reach USD 1,75,184.2 Million by 2026, growing at a compound annual growth rate of 4.87% from 2019 to 2026. The FDP techniques in ...

Panaxynol as a new agent for cancer prevention and treatment

technology@sc.edu — Mon, 12 Sep 2022 06:47:03 GMT

Reference #: 01618 The University of South Carolina is offering licensing opportunities for Panaxynol as a new agent for cancer prevention and treatment Background: National costs for cancer care were estimated to be $208.9 billion in 2020; particularly for colorectal cancer (CRC), the economic burden in the U.S. is estimated to be over $24 billion annually. Given the rising rates of CRC and mortality associated with CRC, it is critical that we develop new strategies to prevent CRC in well-defined high-risk populations including 1) Patients with rare genetic syndromes 2) Patients with Infla...

Water based hypotonic lysis method for Adeno Associated Virus purification

technology@sc.edu — Mon, 12 Sep 2022 06:09:57 GMT

Reference #: 01595 The University of South Carolina is offering licensing opportunities for a hypotonic-solution-based cell lysis method for Adeno Associated Virus purification Background: Adeno Associated Viral vectors have become popular candidates for gene therapy but suffer the drawback of requiring a time-consuming freeze-thaw (FT) lysis or chemical impurity-prone chemical-based cell lysis method for virus production that poses a challenge in keeping the production cost low. Invention Description: Our invention addresses these shortcomings where we developed a simple hypotonic (WH)...

Self-biased 4H-SiC MOS devices for radiation detection

technology@sc.edu — Tue, 06 Sep 2022 05:08:21 GMT

Reference #: 01614 The University of South Carolina is offering licensing opportunities for Self-biased 4H-SiC MOS devices for radiation detection. Background: 4H-Silicon Carbide has a unique combination of physical properties such as excellent carrier transport properties, high breakdown voltage, high displacement threshold, high thermal conductivity, chemical inertness, and mechanical strength, that make it suitable as the only practical wide bandgap (3.27 eV) electronic material for harsh environment device and sensor fabrication. Invention Description: For the first time, we report ...

New Method to Produce PBI Films without using Organic Solvents

technology@sc.edu — Sun, 04 Sep 2022 10:40:17 GMT

Reference #: 01429 The University of South Carolina is offering licensing opportunities for New Method to Produce PBI Films without using Organic Solvents Background: Polybenzimidazole Film is used in membrane electrode assemblies for fuel cells, flow batteries, and hydrogen pumps. The PBI film is a separator between a nickel mesh and carbon felt. The PBI film separates the anode and the cathode to prevent short-circuiting in the battery. The properties of this membrane will affect the battery’s performance significantly. These films are high strength and used for electrochemical cell...

New Approach For Fabricating N-polar AlxGa1-xN Devices

technology@sc.edu — Sun, 04 Sep 2022 10:26:40 GMT

Reference #: 01435 The University of South Carolina is offering licensing opportunities for a new approach for N-polar AlxGa1-xN Devices. Background: A high electron mobility transistor (HEMT) is a transistor that uses an electric field to control the flow of current, which incorporates a junction between two materials with different band gaps where electron states cannot exist. HEMTs have high power performance and can operate at higher frequencies up to millimeter wave, which is attractive for power electronics such as cell phones, TV receivers, and voltage converters. Invention D...

Temperature Responsive Cell Culture Platform for Mechanobiological Manipulation

technology@sc.edu — Sun, 04 Sep 2022 10:20:52 GMT

Reference #: 01436 The University of South Carolina is offering licensing opportunities for Temperature Responsive Cell Culture Platform for Mechanobiological Manipulation Background: The invention pertains to a swellable platform with surface microwells of various shapes that can encapsulate and systematically apply mechanical pressure on cells. The swellable platform is created by a temperature-responsive polymer, where its temperature determines its degree of swelling. The mechanical pressure can serve two main purposes: the first being to create transient holes in the cell membrane allo...

Methods and Integrated Structures of Heat Dissipation for Microwave Antennas

technology@sc.edu — Sun, 04 Sep 2022 09:57:44 GMT

Reference #: 01445 The University of South Carolina is offering licensing opportunities for Methods and Integrated Structures of Heat Dissipation for Microwave Antennas Background: With the significant growth in mobile traffic and number of wireless communication standards, 5G mobile networks are rapidly developed which are forecast to have a larger capacity than current 4G mobile networks, along with capabilities such as multifunction, ultra-high speed, and ultra-low latency. In addition, modern wireless communications, and radar systems, especially in case of MIMO system, are demanded min...

iudgviyudsgfviydshg

technology@sc.edu — Fri, 02 Sep 2022 11:48:50 GMT

juhafodsijhfisudfbisudbcfi

Algorithm for Detection of Real-Time Damage using Acoustic Emissions

technology@sc.edu — Wed, 31 Aug 2022 11:13:22 GMT

Reference #: 01546 The University of South Carolina is offering licensing opportunities for Algorithm for Detection of Real-Time Damage using Acoustic Emissions Background: Other methods of damage detection rely on historical data (meaning that they will need to collect multiple days, weeks, or months of data before they can make a determination in amount of damage). Invention Description: We have developed a method of detecting structural damage of structures using specialized sensors. Using our method, structures can be monitored in real-time to predict damage level. This damage level ...

Transfer of Wide and Ultrawide Bandgap Layers to Engineered Substrate

technology@sc.edu — Tue, 30 Aug 2022 12:29:01 GMT

Reference #: 01577 The University of South Carolina is offering licensing opportunities for Transfer of Wide and Ultrawide Bandgap Layers to Engineered Substrate Background: The intrinsic properties of both wide bandgap (WBG) and ultrawide bandgap (UWBG) semiconductor materials make them suitable for a wide range of other applications in high power and radio frequency (RF) electronics, deep ultraviolet (DUV) optoelectronics, quantum electronics, and high-temperature harsh environment applications. However, the full performance of these materials cannot be achieved due to the thick substrate...

Tyrosine and resveratrol derivatives as novel modulators of cellular serine-ADP-ribosylation

technology@sc.edu — Tue, 30 Aug 2022 12:22:03 GMT

Reference #: 01578 The University of South Carolina is offering licensing opportunities for Tyrosine and resveratrol derivatives as novel modulators of cellular serine-ADP-ribosylation Background: Currently, there are no molecules that specifically inhibit only serine-ADP-ribosylation without affecting global ADP-ribosylation. Invention Description: We discovered that tyrosine and trans-resveratrol selectively inhibit serine-ADP-ribosylation while activating ADP-ribosylation potentially on glutamic and aspartic acid residues. Potential Applications: Our results suggest that increased t...

A method for assessing disparate impact in internet markets

technology@sc.edu — Tue, 30 Aug 2022 09:10:17 GMT

Reference #: 01605 The University of South Carolina is offering licensing opportunities for A method for assessing disparate impact in internet markets Background: Companies increasingly use computer algorithms to make automatic business decisions (e.g., prices) and personalize these decisions for each consumer. Algorithms, however, may unknowingly learn to discriminate against consumers on basis of their gender, race, socioeconomic status, etc. Yet, it is difficult and risky to evaluate algorithms, partly because collecting and holding demographic data can be a liability for businesses. ...

Over-the-Air Computation Methods Based on Balanced Number Systems for FEEL

technology@sc.edu — Tue, 30 Aug 2022 07:03:12 GMT

Reference #: 01612 The University of South Carolina is offering licensing opportunities for Over-the-Air Computation Methods Based on Balanced Number Systems for FEEL Background: Federated edge learning (FEEL) is a distributed learning framework that leverages the computational powers of edge devices (EDs) and uses the local data at the EDs without compromising their privacy to train a model. However, the communication aspect of FEEL is one of the main bottlenecks. Invention Description: To address this issue, one of the promising solutions is to perform the aggregation with over-the-ai...

Mechanism and Methods for Robotic Installation of Stakes

technology@sc.edu — Mon, 29 Aug 2022 06:56:02 GMT

Reference #: 01582 The University of South Carolina is offering licensing opportunities for Mechanism and Methods for Robotic Installation of Stakes Background: Currently, as part of the bell pepper planting process, stakes are needed to provide support for the plant as it begins to grow from a two-three-week-old plant to a fully mature plant. This is a tedious and labor-heavy process. Invention Description: This invention is an autonomous all-terrain robot designed for architectural industries whose purpose is to install support stakes in the plant beds while being able to self-navigati...

Use of delta 8 THC to treat inflammatory and autoimmune diseases

technology@sc.edu — Tue, 09 Aug 2022 08:06:36 GMT

Reference #: 01583 The University of South Carolina is offering licensing opportunities for Use of delta 8 THC to treat inflammatory and autoimmune diseases Background: There are millions of people who suffer from debilitating inflammatory and autoimmune diseases against which there is no cure. Delta-8 THC is present in small quantity in cannabis and not many studies have been done on the bioactivity of this compound. Delta-8 binds to the CB1 receptor with less affinity when compared to delta-9 THC, and thus suspected to produce less psychoactive effects because of which it is better suited...

Spectroscopy Combining Base Stations and UAVs

technology@sc.edu — Mon, 08 Aug 2022 08:57:54 GMT

Reference #: 01581 The University of South Carolina is offering licensing opportunities for Spectroscopy Combining Base Stations and UAVs Background: Existing products to monitor atmospheric constituents consist of stationary passive samplers, FTIR scanners, and UAV-based passive samplers. All these products do not have the ability to accurately measure the three-dimensional extent of an atmospheric chemical that our proposed system will have. Invention Description: This invention is a method of line-of-sight and remote optical measurements using a base station and a remote station. The p...

2-Hydroxyglutarate Enantiomer Detection in Complex I Deficient Encephalopathy

technology@sc.edu — Mon, 08 Aug 2022 08:35:55 GMT

Reference #: 01572 The University of South Carolina is offering licensing opportunities for 2-Hydroxyglutarate Enantiomer Detection in Complex I Deficient Encephalopathy Background: There are genetic diseases that impair the function of the mitochondria, they do not make enough ATP (energy) for demanding tissues such as the brain and muscles. One of the most common of these is known as Leigh Syndrome, and is associated with a failure to thrive, muscle weakness and eventual brain lesions. There are no specific biomarkers of these diseases, and no cures. Invention Description: We measured a...

Routes Optimization System Based on Railroad and Street Traffic Information

technology@sc.edu — Mon, 08 Aug 2022 08:30:38 GMT

Reference #: 01565 The University of South Carolina is offering licensing opportunities for Routes Optimization System Based on Railroad and Street Traffic Information Background: Current navigation systems, such as Google Maps, Apple Maps, calculates the optimal route based on the street traffic information. But still, the travelers would need to spend more time if there are any railroad crossing blockages. The current practice cannot consider the delay due to the railroad-highway crossing blockage. It is always puzzling the travelers and navigation systems should they just wait or find an...

Autonomous Drone for railroad track inspection

technology@sc.edu — Mon, 08 Aug 2022 08:19:38 GMT

Reference #: 01564 The University of South Carolina is offering licensing opportunities for Autonomous Drone for railroad track inspection Background: The current practices suffer from three main drawbacks: 1) Human pilot cost is significant. The schedule of the drone-based track inspection is contingent on the pilot’s availability rather than that of drones or tracks. Also, the images collected by different pilots at the same track segment could vary and depend on the pilots’ operation. 2) The inspection route is subjective. Because the drones are controlled by the pilots, the ...

Sleep Disturbance Chamber for Animal Test Subjects

technology@sc.edu — Mon, 08 Aug 2022 08:16:39 GMT

Reference #: 01562 The University of South Carolina is offering licensing opportunities for Sleep Disturbance Chamber for Rodents Background: As experimenters, if we are gentle handling, it is often difficult to accurately sleep deprive more than 2 animals at one time given that towards the latter end of the protocol, hours 5-6, animals are quite tired and difficult to keep awake. An automated system would alleviate these discrepancies and also allow us to sleep deprive multiple animals at the same time, provided we have multiple chambers. Invention Description: This invention can be used...

Blood-cytokine levels as adverse outcome predictors following biomaterial implant surgery

technology@sc.edu — Tue, 02 Aug 2022 12:26:04 GMT

Reference #: 01566 The University of South Carolina is offering licensing opportunities for Blood-cytokine levels as adverse outcome predictors following biomaterial implant surgery Background: Despite the high number of patients undergoing reconstruction surgery with surgical mesh and the relatively high number of adverse outcomes, there are currently no published methods to predict undesired outcomes of this surgery. In addition, adverse outcomes remain a possibility for other reconstruction surgeries with surgical mesh or other implant materials. Invention Description: This inven...

Auxetic metamaterials guided by blue-phase liquid crystals disclination network

technology@sc.edu — Tue, 02 Aug 2022 12:07:40 GMT

Reference #: 01569 The University of South Carolina is offering licensing opportunities for Auxetic metamaterials guided by blue-phase liquid crystals disclination network Background: Metamaterials with a negative Poisson ratio are known as auxetic structures. Interestingly, auxetic and near-zero Poisson’s ratio (ZPR) responses are ubiquitous spanning from animals’ skins such as cats and snakes to the dimensional stability of aquatic organisms under hydrostatic pressure; however, ZPR is limited to few examples including cork and cancellous bone structures. So far, few metamateri...

Methods for Long-Range Federated Edge Learning with Chirp-Based Over-the-Air Computation

technology@sc.edu — Tue, 02 Aug 2022 11:16:01 GMT

Reference #: 01574 The University of South Carolina is offering licensing opportunities for Methods for Long-Range Federated Edge Learning with Chirp-Based Over-the-Air Computation Background: Federated edge learning (FEEL) deploys federated learning (FL) over a wireless network, in which many edge devices (EDs) participate in training using locally accessible data and an edge server (ES) aggregates the local decisions without accessing the data at the EDs. With FEEL, the communication load can be a challenge as a significant number of model parameters/gradients/updates need to be exchanged...

DRCNN for Multi-task Bearing Fault Diagnosis with Information Fusion

technology@sc.edu — Wed, 27 Jul 2022 10:32:01 GMT

Reference #: 01571 The University of South Carolina is offering licensing opportunities for DRCNN for Multi-task Bearing Fault Diagnosis with Information Fusion Background: First, most industrial systems are working in variable operating conditions and environments. The information of operating conditions, such as load profile, rotating speed, and environmental factors, etc., and domain knowledge, such as fault mode, fault mechanisms, and fault characteristic frequencies, etc., have significant influence on the accuracy and performance of diagnosis. However, this important information is no...

Scalable two-phase cooling plates

technology@sc.edu — Thu, 21 Jul 2022 10:06:06 GMT

Reference #: 01575 The University of South Carolina is offering licensing opportunities for Scalable two-phase cooling plates Background: Two-phase cooling usually fails at relatively low heat loads due to the loss of liquid supply. For real applications, two-phase cooling technologies need to match the size of electronic components. However, the scalability of two-phase flow is very poor. Here we successfully addressed the scalability issue and make it feasible to cool large size electronic devices. Invention Description: The major novelty of this technology is that we greatly improved t...

Methods for Multi-cell Over-the-Air Computation for Distributed Learning

technology@sc.edu — Thu, 21 Jul 2022 07:23:30 GMT

Reference #: 01573 The University of South Carolina is offering licensing opportunities for Methods for Multi-cell Over-the-Air Computation for Distributed Learning Background: Federated edge learning (FEEL) is a distributed learning framework that leverages the computational powers of edge devices (EDs) and uses the local data at the EDs without compromising their privacy to train a model. However, the communication aspect of FEEL stands as one of the main bottlenecks. Invention Description: This invention addresses the communication latency problem of training an artificial intelligence...

Portable Railroad Spike Inspection System based on Acoustic Signals

technology@sc.edu — Thu, 21 Jul 2022 05:18:47 GMT

Reference #: 01567 The University of South Carolina is offering licensing opportunities for Portable Railroad Spike Inspection System based on Acoustic Signals Background: It is reported that broken spikes were observed frequently, including cut spikes, screw spikes, and driven spikes that were used to restrict both tie plates and rails. Since the cracks are typically underneath the spike head, it is very difficult to distinguish the broken spikes without a physical check which raises great challenges in track health evaluation and operation safety. Several recent derailments in Canada and ...

A Method and Apparatus for Slicing Hard, Brittle Materials

technology@sc.edu — Thu, 09 Jun 2022 11:11:34 GMT

Reference #: 00465The University of South Carolina is offering licensing opportunities for this technologyInvention Description:This novel invention involves both a method and apparatus for the slicing of ingots, particularly silicon carbide (SiC) and hard brittle materials. The cutting machine provides a high cutting speed of the ingot.Advantages and Benefits:There are many advantages to this technology, including the following: (1) the wafers produced by this method exhibit low total thickness variation and low depth of surface dama...

Novel Resuscitative fluid for Trauma Patients

technology@sc.edu — Thu, 09 Jun 2022 11:10:01 GMT

Reference #: 00444 The University of South Carolina is offering licensing opportunities for a novel IV fluid to stabilize victims of severe blood loss and hasten recovery without complications in order to reduce stays in intensive care, lower the incidence of pneumonia, and generally cut costs associated with treating victims of hemorrhagic shock. Background: In the United States, accidental injuries/trauma are the leading cause of death in individuals aged 1-44. Most often, hypovolemic shock is secondary to rapid blood loss (hemorrhagic shock). In hemorrhagic shock, blood loss excee...

Electrodes for Fuel Cells and Electrolyzers Containing Multiple Functional Polymers

technology@sc.edu — Thu, 09 Jun 2022 10:51:10 GMT

Reference #: 01550 The University of South Carolina is offering licensing opportunities for Electrodes for Fuel Cells and Electrolyzers Containing Multiple Functional Polymers Background: In fuel cell and electrolyzer electrodes, it is important for ions to be transported throughout the electrode. Typically, this is accomplished with a single ionic polymer, though this can limit the ion transport and the electrochemically active area. Invention Description: This invention allows for efficient ion transport throughout the electrode - increasing the electrochemically active are...

The preparation of a brain targeted artificial nano-enzyme and application

technology@sc.edu — Thu, 09 Jun 2022 10:45:42 GMT

Reference #: 01514 The University of South Carolina is offering licensing opportunities for The preparation of a brain targeted artificial nano-enzyme and application Background: Chronic neuroinflammation is caused by the activation of microglia, which is the major cause of central neuronal system (CNS) diseases, including Alzheimer’s disease, Multiple sclerosis, Brain tumor, glioblastoma, neuroblastoma, Parkinson's disease, Epilepsy, neonatal hypoxic-ischemic, stroke, Amyotrophic lateral sclerosis, Huntington's disease, Spinal cord injury, brain injury, post-traumatic stress ...

Nanoparticle for the remodeling of cancer-associated fibroblast

technology@sc.edu — Thu, 09 Jun 2022 10:44:45 GMT

Reference #: 01513 The University of South Carolina is offering licensing opportunities for Nanoparticle for the remodeling of cancer-associated fibroblast Background: The biomimetic enzyme activity of the cerium oxide nanoparticle (CeNP) prefers ultrasmall particle size and bare surface. Unfortunately, those two features are not favorable for its in vivo application due to easy aggregation and fast renal filtration. To take advantage of the activity of CeNP for cancer therapy, a tumor targeted cerium oxide nanoparticle system, T-CeNP, has been developed. Invention Description: Tumor mic...

Lithium-ion battery health management based on single particle model

technology@sc.edu — Thu, 09 Jun 2022 10:40:59 GMT

Reference #: 01494 The University of South Carolina is offering licensing opportunities for Lithium-ion battery health management based on single particle model Background: A single particle model is used in simulating the behavior of lithium-ion battery. Particle swarm optimization is used to identify the parameters of the single particle model. Single particle is implemented in the LS and Bayesian estimation framework to estimate the battery state of charge and state of health online. Due to integration with Lebesgue sampling, an event-based sampling system where signal is sampled only wh...

Combining Pulmonary Function Test Data with Other Clinical Data

technology@sc.edu — Thu, 09 Jun 2022 10:04:20 GMT

Reference #: 01323 The University of South Carolina is offering licensing opportunities for Combining Pulmonary Function Test Data with Other Clinical Data Background: According to the Centers for Disease Control there are approximately 25 million Americans with asthma and 15 million Americans with COPD. COPD is the third most common cause of death in the USA. Direct health care expenditures for COPD are approximately $30 billion annually. This includes almost 7 million visits to the emergency departments alone. This invention would be an important advance in the diagnosis and medica...

Short-term AE Monitoring to Identifying ASR Progression in Concrete Structures

technology@sc.edu — Wed, 11 May 2022 10:51:45 GMT

Reference #: 01504 The University of South Carolina is offering licensing opportunities for Short-term AE monitoring to identifying ASR progression in Concrete Structures. Background: Alkali-silica reaction (ASR) is one of the aging agents in concrete structures, which endangers structure serviceability and integrity. The reaction causes expansion, and this expansion leads to cracking in structures. A method was developed to monitor the structures and determine the percentage of concrete degradation (cracking). When concrete cracks, vibration waves are emitted from cracking. We record thes...

Electrostatic Effects as a Tool to Adjust Rheological Behavior

technology@sc.edu — Tue, 29 Mar 2022 05:31:31 GMT

Reference #: 01522 The University of South Carolina is offering licensing opportunities for Electrostatic Effects as a Tool to Adjust Rheological Behavior Background: Rheology is the science that studies the flow phenomena of matter and is concerned with the relationship between shear stress and shear strain. Invention Description: Our method provides a tool to tune the behavior of some specific fluids to make them flow easier with increased accessibility in porous media (e.g., oil recovery). Potential Applications: It can be a drilling fluid for the oil well for which our method...

Automated Device for Spinal Rod Contouring

technology@sc.edu — Wed, 02 Mar 2022 05:55:24 GMT

Reference #: 01121The University of South Carolina is offering licensing opportunities for an automated device for spinal rod contouring and cutting. Invention Description:The subject invention links with existing spatial navigation technology and automatically cuts and contours a rod to the surgeon’s specifications for subsequent implantation. It accounts for variations in rod diameter and stiffness, so as to be compatible with smaller diameter rods used in the cervical spine; larger diameter rods used in the thoracolumbar spine; dual diameter rods used in cervicothoracic fusions; and t...

Using Artificial Intelligence to Assess Difficulty Level of Ultrasound Examinations

technology@sc.edu — Wed, 19 Jan 2022 12:23:48 GMT

Reference #: 01503 The University of South Carolina is offering licensing opportunities for Using Artificial Intelligence to assess difficulty level of ultrasound examinations. Background: The use of ultrasound is rapidly expanding across virtually all levels of medical practice. Ultrasound is a very operator-dependent modality compared to other imaging modalities like CT and MRI. To ensure a high level of medical practice as it relates to ultrasound use, it is essential to be able to adequately assess the competency level of those using ultrasound. Invention Description: Artificial inte...

Thermoplastic composite utilizing torrefied biomass

technology@sc.edu — Wed, 19 Jan 2022 12:18:41 GMT

Reference #: 01515 The University of South Carolina is offering licensing opportunities for Thermoplastic composite utilizing torrefied biomass Background: This invention solves two primary problems. First, it provides a use for waste forestry and agricultural biomass, which currently do not have attractive commercial uses resulting in forest fires or open controlled burns, which result in reduced air quality. These issues have become more prominent in recent years with increased forest fire damage across the United States. Overseas, open burning of agricultural waste impacts air quality to...

Isomer-specific Neuroprotective Effect of Natural Resveratrol

technology@sc.edu — Tue, 18 Jan 2022 12:32:15 GMT

Reference #: 01516 The University of South Carolina is offering licensing opportunities for Isomer-specific Neuroprotective Effect of Natural Resveratrol Background: Resveratrol (RSV) has been used in clinical trials against a multitude of human disease conditions, including COVID-19 and Alzheimer’s Disease (AD). Although some of these studies demonstrated positive outcomes at lower doses, unexpectedly, higher doses of RSV instead brought out detrimental outcomes, sparking controversy over the effectiveness of RSV in human health. Despite decades of research, the molecular basis of th...

Building Teams for Request for Proposals

technology@sc.edu — Tue, 18 Jan 2022 12:28:46 GMT

Reference #: 01530 The University of South Carolina is offering licensing opportunities for Building Teams for Request for Proposals Background: Today, there is limited automation to alert University researchers about available opportunities. As a result, faculties must manually go to websites of funding agencies and keep track of RFPs that they may discover. Invention Description: The described computer system and a computer method recommends a list of teams of experts from various faculties and departments of the organization, like university, that would best fit the needs of the ...

Hand Waving Based Mutual Authentication for Drone Delivery

technology@sc.edu — Tue, 18 Jan 2022 12:25:46 GMT

Reference #: 01533 The University of South Carolina is offering licensing opportunities for Hand Waving Based Mutual Authentication for Drone Delivery Background: When a drone is delivering a package to a user, it has to make sure the person waiting there is the real user. Similarly, when a user uses a drone to send a package, she needs to make sure the drone approaching is the valid one, rather than one controlled by an attacker. Thus, we need mutual authentication between the drone and the user. Invention Description: This innovation proposes to use the correlation between the dro...

Luteolin for treatment of neuromuscular movement disorder dystonia 16 (DYT16)

technology@sc.edu — Thu, 13 Jan 2022 13:00:59 GMT

Reference #: 01544 The University of South Carolina is offering licensing opportunities for Luteolin for treatment of neuromuscular movement disorder dystonia 16 (DYT16) Background: DYT16 is a rare movement disorder, so the number of patients worldwide is small. However, Alzheimer's disease, Down syndrome are very prevalent and large numbers of people are affected. Alzheimer’s: 5.5 million in USA and 24 million worldwide. Down syndrome: in USA 83,000 children had DS in 2002. Numbers are huge. Invention Description: PKR is a protein kinase that is activated by association with a...

Single atom catalysts for hydrogen oxidation in fuel cells

technology@sc.edu — Thu, 13 Jan 2022 12:56:25 GMT

Reference #: 01545 The University of South Carolina is offering licensing opportunities for Single atom catalysts for hydrogen oxidation in fuel cells Background: Low temperature polymer electrolyte fuel cells have the potential to provide clean, renewable, power for mobile, stationary and transportation applications. However, proton exchange membrane fuel cells (PEMFCs) have fallen short of widespread usage due to high cost at the cell-level and systems-level. Invention Description: This innovation is an inexpensive platinum group metal free catalyst for the hydrogen oxidati...

Chiral photonic inks for 3D printing of iridescent architectures

technology@sc.edu — Wed, 12 Jan 2022 12:24:00 GMT

Reference #: 01549 The University of South Carolina is offering licensing opportunities for Chiral photonic inks for 3D printing of iridescent architectures Background: Currently, most colorings used in various applications are limited in range and come from artificial chemical formulations. Invention Description: The present innovation provides chiral inks formulations for extrusion-based 3D-printing of sustainable, biocompatible materials that display colors across the visible light spectrum without the use of any colorants such as pigments or dyes. The source of color in these materia...

Alteration of Albomycin for the Treatment of Bacterial Infections

technology@sc.edu — Wed, 12 Jan 2022 12:18:32 GMT

Reference #: 01438 The University of South Carolina is offering licensing opportunities for Alteration of Albomycin for the Treatment of Bacterial Infections Background: There are numerous antibiotics on the market: however, resistance to almost all of these have been reported in some fashion. Invention Description: The invention proposes to alter a naturally occurring antibiotic to broaden its spectrum of activity. Specifically, the naturally occurring antibiotic in question has two parts, one of which functions to deliver the antibiotic to the cytoplasm of bacteria and the second part p...

Bilayer Ceramic Interconnect

technology@sc.edu — Thu, 04 Nov 2021 06:12:35 GMT

Reference #: 01496 The University of South Carolina is offering licensing opportunities for Bilayer Ceramic Interconnect Background: Interconnect (IC) is a component connecting two adjacent cells in a solid oxide cell to build up voltage and power. LaCrO3-based ceramic ICs is commonly employed in tubular solid oxide fuel cells (SOFCs). However, it faces severe challenges in manufacturability, durability, and cost, primarily due to Cr volatilization issue. Invention Description: This patent disclosure describes a new bilayer ceramic interconnect for tubular solid oxide cells and bund...

Non-contacting Temperature Measurement System for Automated Fiber Placement

technology@sc.edu — Wed, 03 Nov 2021 09:34:12 GMT

Reference #: 01497 The University of South Carolina is offering licensing opportunities for Non-contacting Temperature Measurement System for Automated Fiber Placement Background: Automated Fiber Placement research is plagued by the inability to accurately measure temperature of materials as they are being placed on a mold. Existing temperature measurement methods utilize thermocouples and infrared thermography. Neither of these methods can detect the temperature within the material. They can only measure surface temperature. Invention Description: A device wirelessly transmits an e...

Non-Newtonian Materials for the Prevention of Mild Traumatic Brain Injury

technology@sc.edu — Fri, 01 Oct 2021 10:36:35 GMT

Reference #: 01212 The University of South Carolina is offering licensing opportunities for a non-Newtonian material for the prevention of mild traumatic brain injury. Background: Head impacts and concussions caused by contact sports are a growing source of concern around the United States as concussions are a major health problem in both youth and professional sports. According to the Center for Disease Control (CDC), the number of reported concussions has doubled in the last 10 years. In 39% of the cases, cumulative concussions eventually lead to permanent neurologic disability. This pro...

Deep-scaling of deep ultraviolet micro-sized emitters and modular interconnection thereof

technology@sc.edu — Thu, 23 Sep 2021 11:11:28 GMT

Reference #: 01529 The University of South Carolina is offering licensing opportunities for Deep scaling of deep ultraviolet micro-sized emitters and modular interconnection thereof. Background: One of the main problems with deep ultraviolet (DUV) light-emitting diodes (LEDs) is that they get hot while they are operating, limiting the amount of power that you can put in the LED and limiting how much light the LED can produce. Invention Description: We have greatly alleviated this thermal management issue for DUV LEDs by shrinking down the size and equipping them with an effective bu...

Hearing Screening Simulator Application

technology@sc.edu — Thu, 23 Sep 2021 11:10:18 GMT

Reference #: 01519 The University of South Carolina is offering licensing opportunities for Hearing Screening Simulator Application Background: Speech-Language Pathologists conduct hearing screening tests to try to identify hearing problems early. If a potential problem is identified, the subject is sent for a full hearing evaluation. The problem is that there is no existing system to provide training except using the physical devices. This is expensive and does not address remote learner. Invention Description: Software-based Simulator to provide speech and hearing students the abi...

Artificial Cochlea for Mechanical Processing of Sound

technology@sc.edu — Thu, 23 Sep 2021 11:07:53 GMT

Reference #: 01491 The University of South Carolina is offering licensing opportunities for Artificial Cochlea for Mechanical Processing of Sound Background: So far in our society, the artificial processing of sound is achieved through microphones and digital electronics systems, which are not always reliable. However, natural organisms do it differently. Biology uses a mechanical device to process the sound in various ranges of frequencies dependent on different animals’ evolutionary history. A cochlea inside our inner ear is responsible for our hearing and by nature’s choice i...

High Voltage Energy Harvesting and Sensing With 3D Spiral Design

technology@sc.edu — Thu, 23 Sep 2021 11:07:13 GMT

Reference #: 01488 The University of South Carolina is offering licensing opportunities for High Voltage energy harvesting and sensing with 3D Spiral Design Background: Due to the limited availability and high depletion rates of nonrenewable energy sources as well as environmental concerns, the scientific community is urged to explore and harness alternative, clean energy sources. One most frequently considered alternative clean source of energy is the acoustic energy, for example ambient vibrations, industrial noises, daily mechanical actions like, walking, running, talking, or any other k...

Nano-amended Cement Composites for Nuclear Waste Storage

technology@sc.edu — Thu, 23 Sep 2021 11:04:41 GMT

Reference #: 01389 The University of South Carolina is offering licensing opportunities for nano-amended cement composites for nuclear waste storage. Background: Cement waste forms are typically used to store low-level nuclear waste, for which the primary isotope of interest is technetium (Tc). Several studies have demonstrated the rapid re-oxidation of Tc when exposed to moderate levels of oxygen and the difficulty in reducing Tc in its mobile form. Invention Description: Incorporating well-dispersed and chemically affine multiwalled carbon nanotubes in cement waste forms as a mea...

Methods for Reliable Over-the-Air Computation with Pulses for Distributed Learning

technology@sc.edu — Thu, 23 Sep 2021 11:01:22 GMT

Reference #: 01541 The University of South Carolina is offering licensing opportunities for Methods for Reliable Over-the-Air Computation with Pulses for Distributed Learning Background: Federated edge learning (FEEL) is an implementation of federated learning (FL) over a wireless network to train a model by using the local data at the edge devices (EDs) without uploading them to an edge server (ES). Within each iteration of FEEL, a substantial number of parameters (e.g., model parameters or model updates) from each ED needs to be transmitted to the ES for aggregation. Thus, the communicati...

Li-ion-Battery State-of-charge diagnosis-prognosis based on Lebesgue-sampling equivalent-circuit-model

technology@sc.edu — Mon, 16 Aug 2021 08:42:22 GMT

Reference #: 01527 The University of South Carolina is offering licensing opportunities for Li-ion-Battery State-of-charge diagnosis-prognosis based on Lebesgue-sampling equivalent-circuit-model. Background: Traditional SOC estimation and prediction is mainly based on the electrochemical model (EM) or ECM of Li-battery. The EM method has a high computation cost and ECM cannot simulate behavior accurately with the effect of battery degradation. Invention Description: The innovation identifies the parameters of ECM by fitting a series of selected OCV (open circuit voltage) points with cons...

Real-Time PCR loading platform

technology@sc.edu — Tue, 03 Aug 2021 09:36:08 GMT

Reference #: 00675 The University of South Carolina is offering licensing opportunities for a platform that allows researchers to consistently and accurately reproduce small amounts of reaction mixes for real-time PCR. Potential Applications: This platform is used in real-time polymerase chain reaction experimentation. Advantages and Benefits: Shows the investigator exactly which wells have been loaded and which are to be loaded next No external light is applied, unlike previous devices which interfered with the florescent chemistries used in the PCR Extremely user-fri...

Friction Stir Welding Assisted Induction Welding of Fiber Reinforced Polymers

technology@sc.edu — Fri, 18 Jun 2021 08:20:04 GMT

Reference #: 01074 The University of South Carolina is offering licensing opportunities for Friction Stir Welding Assisted Induction Welding of Fiber Reinforced Polymers Background: Thermoplastic matrix composites (TPMC) have several advantages over thermosetting composites (TSMC). They are re-processable and joints between TPMC parts can be made by fusion bonding, creating cohesive joints that are in many ways preferable over the adhesive and mechanical joints used for assembly of TSMC structures. Even though industrial applications have shown that thin-walled TPMC shells can be built effe...

Emodin Inhibits Colorectal Tumorigenesis and Ameliorates Toxicity Associated With Chemotherapy

technology@sc.edu — Fri, 18 Jun 2021 08:07:19 GMT

Reference #: 01294 The University of South Carolina is offering licensing opportunities for Emodin Inhibits Colorectal Tumorigenesis and Ameliorates Toxicity Associated with Chemotherapy Background: Colorectal cancer is one of the most common malignancies, accounting for approximately 1.36 million new cases worldwide annually. It is the third most common cancer diagnosed in both men and women in the United States. It is estimated that 95,520 new cases of colon cancer will be diagnosed in 2017 in the US alone. Overall, the lifetime risk of developing colorectal cancer is about 1 in 21 (4.7%)...

Continuous Fiber Impregnation for Additive Manufacturing Using In-line Polymerization

technology@sc.edu — Fri, 18 Jun 2021 07:51:00 GMT

Reference #: 01380 The University of South Carolina is offering licensing opportunities for Continuous Fiber Impregnation for Additive Manufacturing Using In-line Polymerization Background: The growth of new and evolving 3D printers has stemmed from a desire for efficient manufacturing that can be used to produce many complex geometries. The development of appropriate materials and filaments for these printers is also essential. One of the many applications of a 3D printer is to print custom parts. Currently, certain parts are printed but are not strong enough to withstand the everyday forc...

Low-Level Communication Between Energy Prosumers in a DC Microgrid

technology@sc.edu — Fri, 18 Jun 2021 07:47:57 GMT

Reference #: 01387 The University of South Carolina is offering licensing opportunities for Low-Level Communication Between Energy Prosumers in a DC Microgrid Background: In the case of a microgrid, any connected device, defined as the prosumers, has taken on the role to both consume and produce energy. In fact, the increasing use of renewable energy and local storage has increased the opportunity for prosumers to export energy back to the grid. Furthermore, the optimized utilization of energy within the microgrid may rely on the cooperation of all renewable and storage sources of the entir...

An Interactive Educational Aid

technology@sc.edu — Thu, 10 Jun 2021 10:34:24 GMT

Reference #: 01505 The University of South Carolina is offering licensing opportunities for An Interactive Educational Aid Background: Teaching methods, tools and resources are the key to comprehensive understanding. However, most of the teaching/learning mode is textbook based that primarily delivers bookish knowledge and lacks the core fundamental understanding of the subject matter. Of late, illustrations, diagrams, flow charts and other interactive tools are being used to supplement textbook teaching/learning, but they have not been integrated fully to cater to the basic understan...

Scalable Method to Produce Single-Atom Catalysts on Support Substrates

technology@sc.edu — Thu, 10 Jun 2021 10:25:35 GMT

Reference #: 01539 The University of South Carolina is offering licensing opportunities for Scalable Method to Produce Single-Atom Catalysts on Support Substrates Background: Useful chemicals are widely synthesized by homogeneous transition metal-catalyzed reactions. However, the aggregation and precipitation of atomically dispersed catalysts cause considerable loss of activity. This has spurred interest in the heterogenization of atomically dispersed catalysts to impart stability and facilitate recyclability. The current synthesis methods are not scalable and do not yield a high density of...

Semi-Stochastic Boolean-Neural Hybrids for Solving Hard Problems

technology@sc.edu — Tue, 08 Jun 2021 07:20:59 GMT

Reference #: 01457 The University of South Carolina is offering licensing opportunities for Semi-Stochastic Boolean-Neural Hybrids for Solving Hard Problems Background: Currently, there exist several emerging approaches for solving hard computational problems. Quantum computation offers algorithms that in principle allow finding solutions of some problems on quantum computers exponentially faster compared to the classical ones. A well-known example is Shor’s factorization algorithm. Up to now, however, Shor’s algorithm has been demonstrated experimentally only on a small number ...

Acoustic Emission Damage Classification of Rotating Machinery via Intensity Analysis

technology@sc.edu — Tue, 08 Jun 2021 07:17:59 GMT

Reference #: 01474 The University of South Carolina is offering licensing opportunities for Acoustic Emission Damage Classification of Rotating Machinery via Intensity Analysis Background: Acoustic Emission (AE): “the class of phenomena whereby transient elastic waves are generated by the rapid release of energy from localized sources within a material, or the transient waves so generated”. AE parameters can detect defects prior to the appearance on the vibration acceleration range for thrust loaded ball bearings. Acoustic parameters for the recognition of defects in radially lo...

Methods for Reliable Over-the-Air Computation and Federated Edge Learning

technology@sc.edu — Tue, 08 Jun 2021 07:09:05 GMT

Reference #: 01538 The University of South Carolina is offering licensing opportunities for Methods for Reliable Over-the-Air Computation and Federated Edge Learning Background: Federated edge learning (FEEL) is a distributed learning framework that leverages the computational powers of edge devices (EDs) and uses the local data at the EDs without compromising their privacy to train a model. However, the communication aspect of FEEL stands as one of the main bottlenecks. To address this issue, one of the promising solutions is to perform the aggregation with over-the-air computation (AirCom...

Human-Perceptible and Machine-Readable Shape Generation and Classification of Hidden Objects

technology@sc.edu — Tue, 08 Jun 2021 07:08:31 GMT

Reference #: 01537 The University of South Carolina is offering licensing opportunities for Human-Perceptible and Machine-Readable Shape Generation and Classification of Hidden Objects Background: Millimeter-wave (mmWave) systems enable through-obstruction imaging and are widely used for screening in state of-the-art airports and security portals. They can detect hidden contrabands, such as weapons, explosives, and liquids, by penetrating wireless mmWave signals through clothes, bags, and non-metallic obstructions. Besides, mmWave imaging systems could enable applications to track beyond li...

Highly Usable and Secure Pairing for IoT Devices

technology@sc.edu — Tue, 08 Jun 2021 07:07:53 GMT

Reference #: 01534 The University of South Carolina is offering licensing opportunities for Highly Usable and Secure Pairing for IoT Devices Background: After you purchase a new IoT device, it is painful to connect it to your home WiFi or pair it with your smartphone. Very often, the process can be hacked by your neighbor or a remote attacker, as the new device may get paired with the attacker or you leak your home WiFi password to the attacker. It is either a burden for IoT manufacturers, as they have to assign a unique pairing password for each IoT device’s firmware and print it cor...

Functional Coatings for Enhanced Tamper Indication

technology@sc.edu — Thu, 03 Jun 2021 12:56:07 GMT

Reference #: 00973 Background: Laser surface authentication (LSA) is a key process in seal verification and allows for unique identification of inorganic objects, much like a fingerprint. Therefore, it is imperative that all materials, surface preparations and potential coatings being developed are compatible with this technique. Like a fingerprint, one potential concern a mold or copy of the intrinsic surface features could be made to reproduce a counterfeit. Novel material coatings and coating combinations will enable the fabrication of low-cost, tamper indication devices. The s...

Use of FC101 as an Anti-Angiogenesis Lead Compound for Developing Chemotherapeutic Agents for Cancer and Other Angiogenic Diseases.

technology@sc.edu — Thu, 03 Jun 2021 12:40:36 GMT

Reference #: 00124 Invention Description: The subject invention describes the use of Fusarochromanone (FC101), a fungal metabolite known to cause avian tibial dyschondroplasia. FC101 is an inhibitor of angiogenesis, lymphocytic development, and importantly the proliferation of many human cancer cell lines. FC101 has highly selective action, inhibiting growth of many melanoma cell lines with IC50 values in the 0.5 nM range, as well as various lung cancer and colon cancer cells in the 10-50 nM range. FC101 has low toxicity toward nonproliferating cells, but does inhibit proliferation o...

Separation of oil water mixtures using nanotechnology

technology@sc.edu — Thu, 03 Jun 2021 11:23:54 GMT

Reference #: 01077 The University of South Carolina is offering licensing opportunities for low-cost nanoparticles for pollutant and waste removal. Background: Rapid removal of oil from the water surface is important to mitigate the harmful environmental effect of fast spreading oil spills. Different oil spill cleanup techniques like physical sorption via porous sorbents, mechanical recovery with skimmers, in situ burning, dispersant mediated physical diffusion, and biodegradation have been used to this effect. However, cost, and time are challenges for the existing cleanup methods. Further...

AI method-apparatus for extracting crack-length from high-frequency AE signals

technology@sc.edu — Tue, 01 Jun 2021 11:23:43 GMT

Reference #: 01536 The University of South Carolina is offering licensing opportunities for AI method-apparatus for extracting crack-length from high-frequency AE signals Background: In metallic structures, fatigue cracks are inevitable and need to be detected and quantified. However, the crack length information is hard to be estimated. It is imperative to detect these cracks and quantify their length at the earliest to avoid catastrophic failures of these structures. Invention Description: The proposed invention has the capability to estimate fatigue crack length in sheet-metal structur...

Persistent Micelle Corona Chemistry

technology@sc.edu — Tue, 01 Jun 2021 11:22:27 GMT

Reference #: 01535 The University of South Carolina is offering licensing opportunities for Persistent Micelle Corona Chemistry Background: Polymer micelles have found significant uses in areas such as drug/gene delivery, medical imaging, and as templates for nanomaterials. For many of these applications, the micelle performance depends on its size and chemical functionalization. To date, however, these parameters have often been fundamentally coupled since the equilibrium size of a micelle is a function of the chemical composition in addition to other parameters. Invention Description: T...

Treating Prostate Cancer with Tartrate Ions

technology@sc.edu — Wed, 26 May 2021 12:46:31 GMT

Reference #: 00088 The University of South Carolina is offering licensing opportunities for a new method to treat prostate cancer via inhibition of prostatic acid phosphatase. Invention Description: The subject invention is able to detect and specifically inhibit prostatic acid phosphatase (PAP), a major protein secreted by the prostate gland. PAP is produced in large quantities by metastatic (specifically, cancerous) prostate cells. PAP has been shown in vitro to inhibit natural killer (NK) cells, one of the body's internal defense mechanisms against cancer. The inhibiti...

System for Monitoring and Maintaining Separation among Pets, People, or Objects

technology@sc.edu — Wed, 26 May 2021 10:37:06 GMT

Reference #: 01227 The University of South Carolina is offering licensing opportunities for System for Monitoring and Maintaining Separation among Pets, People, or Objects Background: The current state of the art for fencing in pets electronically is to have a powered transmission source (either a continuous wire, or a stand-alone charged or wired pod), and a receiver collar on the pet. This solution works well to keep pets in a desired zone. However, within that zone, different pets could still interact with each other in ways that could be harmful or unpleasant. Invention Description: T...

Spatially Resolved Fourier Transform Impedance Spectroscopy and Applications to Optoelectronics

technology@sc.edu — Tue, 25 May 2021 12:54:45 GMT

Reference #: 01502 The University of South Carolina is offering licensing opportunities for Spatially Resolved Fourier Transform Impedance Spectroscopy and Applications to Optoelectronics Background: The key problems that this innovation overcomes are the tradeoffs in time domain techniques used to characterize light-responsive materials as well as devices such as solar cells and photodetectors. As both the energy demands of society and the exploration of novel materials and devices to address them continue to grow, so does the need for the development of diagnostic techniques that may be s...

Regenerative Tissue-Mimetic Multilayer Fused Microgel-Cell Construct

technology@sc.edu — Tue, 25 May 2021 12:41:34 GMT

Reference #: 01470 The University of South Carolina is offering licensing opportunities for Regenerative Tissue-Mimetic Multilayer Fused Microgel-Cell Construct Background: Tissue engineering aims to make cellular constructs for implantation in an injured tissue defect in a human patient to restore, maintain, repair, regenerate or improve the function of the injured tissue. Invention Description: A novel composition and process to form multilayer microgel-cell construct as constructs for implantation in a tissue defect using decellularized, micronized tissue particles as microcarriers fo...

Minimally Invasive and Semi-Automated Myocardial Injection Device

technology@sc.edu — Mon, 24 May 2021 09:43:13 GMT

Reference #: 01450 The University of South Carolina is offering licensing opportunities for Minimally Invasive and Semi-Automated Myocardial Injection Device Background: Approximately, 550,000 first episodes and 200,000 recurrent episodes of acute myocardial infarction occur annually. Invention Description: This device is designed and optimized to perform automated and minimally invasive intramyocardial injections for cardiac repair. Our technology eliminates the need for opening of chest cavity for injections of therapeutics to the heart muscle after heart attack, can detect the diseased...

Heat Dissipation for Millimeter-Wave Devices with Antenna Switching

technology@sc.edu — Wed, 19 May 2021 11:29:37 GMT

Reference #: 01477 The University of South Carolina is offering licensing opportunities for Heat Dissipation for Millimeter-Wave Devices with Antenna Switching Background: Millimeter-wave is the core technology for 5G and beyond wireless systems; it enables use cases that demand multiple Gbps throughput and ultra-low latency connectivity, such as immersive virtual and mixed reality, tactile internet, telesurgery, control for smart infrastructures, and autonomous vehicles safety. The devices need to operate at very high frequency and bandwidth; so, they consume more energy, dissipate more po...

Facilitating At-Home Spirometry with Millimeter-Wave Devices

technology@sc.edu — Wed, 19 May 2021 11:27:15 GMT

Reference #: 01523 The University of South Carolina is offering licensing opportunities for Facilitating At-Home Spirometry with Millimeter-Wave Devices Background: Due to the steady rise of COVID-19 cases and its long-haul syndromes, a broader set of people will now require continuous lung function monitoring. At-home spirometry tests allow to continuously monitor for recovery, detect changes, and gather long-term lung function evolution. Invention Description: We propose a low-barrier means to perform at-home spirometry tests using built in technology already available on 5G smart devic...

Transforming Cheap Spirometers to Estimate Flow-Volume Graph By Deep Learning

technology@sc.edu — Wed, 19 May 2021 11:25:38 GMT

Reference #: 01526 The University of South Carolina is offering licensing opportunities for Transforming Cheap Spirometers to Estimate Flow-Volume Graph By Deep Learning Background: Respiratory diseases, like Asthma, COPD, have been a significant public health challenge over decades, and the recent COVID-19 pandemic has worsened the situation. Portable, home-use spirometers are effective in continuous monitoring of respiratory syndromes out-of-clinic. Invention Description: The technology designs a deep residual decoder network for curve learning then takes key indicators as the inp...

Robust useful and general task-oriented virtual assistants

technology@sc.edu — Mon, 17 May 2021 06:02:54 GMT

Reference #: 01532 The University of South Carolina is offering licensing opportunities for Robust useful and general task-oriented virtual assistants. Background: The use of voice assistants (VA) for various tasks is on the rise. It is estimated that by 2024, the number of voice assistants will reach 8.4 billion units - a number higher than the world population. From general chit-chat to controlling smart home appliances, the VAs are currently capable of performing a wide-array of tasks. However, the tasks are atomic and are only compatible with a single-turn instruction. Invention Descri...

ReOx-Pd/CeO2 Catalyst for the Hydrodeoxygenation of Xylitol

technology@sc.edu — Fri, 14 May 2021 11:14:56 GMT

Reference #: 01366 The University of South Carolina is offering licensing opportunities for Methods and Compositions for hydrodeoxygenation of carbohydrates and carbohydrate analogs Background: Lignocellulosic biomass upgrading can provide a useful tool for producing value chemicals using widely available, renewable resources. Derivates from lignocellulosic biomass, such as carbohydrates or carbohydrate analogs, may provide useful starting materials for synthesizing value chemicals without requiring fossil fuels. Invention Description: This catalyst, processes and covers reaction conditio...

Method and Design of High-Performance Interconnects with Improved Signal Integrity

technology@sc.edu — Fri, 14 May 2021 08:01:15 GMT

Reference #: 01444 The University of South Carolina is offering licensing opportunities for Method and Design of High-Performance Interconnects with Improved Signal Integrity Background: Over the last few decades, there has been a progressively expanded tendency of increasing trace density on printed circuit boards (PCBs) and silicon dies in the semiconductor industry toward higher levels of integration and multi-core architecture generates chips with densities of hundreds of billions of transistors, driven by the requirement of low-cost and highly compact designs, such as miniaturized mult...

Methods and Compositions for Treating Obesity

technology@sc.edu — Fri, 14 May 2021 07:03:53 GMT

Reference #: 01347 The University of South Carolina is offering licensing opportunities for Targeting MicroRNA-466 Family and MicroRNA-762 to Prevent Inflammation Driven Obesity Background: The incidence of obesity has grown significantly in the last 25 years leading to upwards of 1.45 billion overweight adults in the world, of which approximately 500 million are obese. This triggers chronic disease states, including type 2 diabetes, metabolic syndromes and cardiovascular disease, which together contribute to high rates of mortality and morbidity. Invention Description: We have identified...

A Nanopore Method for Identifying Single Amino Acid in Oligopeptides

technology@sc.edu — Fri, 14 May 2021 06:55:34 GMT

Reference #: 01471 The University of South Carolina is offering licensing opportunities for A Nanopore Method for Identifying Single Amino Acid in Oligopeptides Background: The primary sequence of a protein or a peptide is essential to its identification and function. In the area of personalized diagnosis and therapeutics, an accurate proteomic information of proteins or peptides as biomarkers can much better reflect an individual’s health status than the genomic information. Classical proteomics techniques, such as mass spectrometry (MS), are less sensitive and reproducible when dete...

Anti-CCL8 Antibodies for COVID-19 and Other Immune Related Conditions

technology@sc.edu — Fri, 14 May 2021 06:52:11 GMT

Reference #: 01487 The University of South Carolina is offering licensing opportunities for Anti-CCL8 Antibodies for COVID-19 and Other Immune Related Conditions Background: CCL8 (MCP-2) is a chemo attractive cytokine that is involved in the pathogenesis of various pathologies including cancer, autoimmune disorders, graft versus host disease and microbial infections. More recently it was also shown to be significantly stimulated during acute respiratory distress syndrome in severely ill COVID-19 patients. Invention Description: We have obtained experimental evidence that anti-CCL8 treatme...

Multiple Format Instructional Display Matrix Including Real Time Input

technology@sc.edu — Thu, 13 May 2021 10:40:08 GMT

Reference #: 01301The University of South Carolina is offering licensing opportunities for the Reality Instructional Medical System (RIMS), a multi-format instructional display matrix including real time input. Background:Teaching and learning complex content and concepts, such as those in medical education, present significant challenges for instructors and learners. Invention Description:This invention combines various forms of visual and auditory input in a systematic way that allows the instructor to present real-time clinical data and/or recorded content to dramatically enhance...

One-Step Synthesis of Phosphate-Based Inhibitors and Applications Thereof

technology@sc.edu — Thu, 13 May 2021 10:35:17 GMT

Reference #: 01236 The University of South Carolina is offering licensing opportunities for using ribose 5-phosphate isomerase inhibitors to treat against kinetoplastid parasites. Background Trypanosoma cruzi protozoa are the causative agent for Chagas’ disease, a neglected tropical disease that affects 6 – 7 million people worldwide. There are two treatment options available for Chagas’ disease and they include benznidazole and nifurtimox. These drugs have the potential for resistance because they were developed over 35 years ago and alternative drugs have no...

3D Printed Carbon Induction Receptors for Welding of GFRTP

technology@sc.edu — Thu, 13 May 2021 10:31:36 GMT

Reference #: 01207 The University of South Carolina is offering licensing opportunities for access to a method for Induction welding of glass fiber reinforced thermoplastic composites using carbon filament susceptors. Background: USC has developed a 3D printer for continuous carbon fiber. This machine can be used to print the receptors on a glass fiber reinforced thermoplastic polymer part. KVE developed induction welding technology; they introduced the most efficient assembly technology (KVE Induct welding technology) for carbon reinforced thermoplastic laminates available to date. The goa...

A Porous Lightweight Metal Supported All Solid State Battery

technology@sc.edu — Thu, 13 May 2021 10:29:43 GMT

Reference #: 01206 The University of South Carolina is offering licensing opportunities for a porous lightweight metal supported all solid state battery that can deliver higher performance characteristics than traditional Lithium-ion batteries Background: Lithium-ion batteries are in common use. However they have a number of limitations; one of which is that they are susceptible to overheating and in some instances, even fires. The main reason for these mishaps is the use of liquid electrolyte (organic solvent) in Lithium-ion batteries. These problems have necessitated the need for the deve...

Dual Conductor Surface Modified SOFC Cathode Particles and Methods

technology@sc.edu — Thu, 13 May 2021 10:25:53 GMT

Reference #: 01183 The University of South Carolina is offering licensing opportunities for the fabrication of highly controlled barrier coatings on solid oxide fuel cell cathodes powders to reduce migration of cations to the surface of the sintered cathode. Invention Description: The subject invention describes the use of atomic layer deposition (ALD) to deposit a uniform layer of oxide-based ceramic films with dual conductivity on solid oxide fuel cell (SOFC) cathode powders. The powders are then sintered to form a cathode with improved properties. The dual conducti...

Force Estimation and Event Localization using Structural Vibrations

technology@sc.edu — Thu, 13 May 2021 10:22:34 GMT

Reference #: 01180 The University of South Carolina is offering licensing opportunities for an algorithm for force estimation and localization of impacts to any structure. Invention Description: The subject invention enables location and force estimation of an impact anywhere within/on a structure (e.g. office building), using an algorithm that analyzes vibrations caused by an impact. Advantages and Benefits:The algorithm for FEEL (force estimation and event localization) offers a number of advantages including: Accurate estimation (99% confidence interval that force is within -2% +/- 1.3%) of...

Round the Clock Structural Health Monitoring System for Aircraft Moveables

technology@sc.edu — Thu, 13 May 2021 10:18:26 GMT

Reference #: 01163 The University of South Carolina is offering licensing opportunities for a Round the Clock Structural Health Monitoring System for Aircraft Moveables Background: Structural Health Monitoring (SHM) is an important technology that helps improve the reliability and safety of aeronautical and civil structures, while at the same time supporting their effective maintenance. A lot of the available SHM systems are either passive or active by design. The subject invention attempts to harness the dual advantages that a hybrid option would provide while simultaneously reducing the o...

Novel Materials & Methods to Create Defined Architectures in Hydrogels

technology@sc.edu — Thu, 13 May 2021 10:10:42 GMT

Reference #: 00944The University of South Carolina is offering licensing opportunities for a biofabrication platform that can be tuned to mimic the native in vivo architecture and geometries vital to the physiological function of tissue.Invention Description:The subject invention is a new material for molding intrinsic geometries to an in vitro collagen hydrogel by allowing the adequate transfer of the specific architectural features to a natural scaffold material. These biomaterials have a true 3D architecture and are created with flow channels or tissue voids that replicate functionality of ...

Novel Locking Total Knee Replacement Design for Treatment of Knee Extensor Weakness

technology@sc.edu — Thu, 13 May 2021 09:56:07 GMT

Reference #: 01007The University of South Carolina is offering licensing opportunities for novel knee implants that allow the user to flex the implant using manual and magnetic features, thereby increasing mobility and reducing fatigue.Invention Description:The subject invention is a lockable knee implant. It allows for knee flexion when desired by the user and also locks into a fixed or semi-rigid configuration for structurally stable stance or walking, similar to an arthrodesis or still gait. The device is a variation of a stabilized total knee replacement used for reconstructive surgery ba...

N-Polar AlxGa1-xN Templates for Electronic and Optoelectronic Devices

technology@sc.edu — Thu, 13 May 2021 09:41:42 GMT

Reference #: 01434 The University of South Carolina is offering licensing opportunities for new approaches for fabricating N-Polar AlxGa1-xN Templates for Electronic and Optoelectronic Devices. Background: A high electron mobility transistor (HEMT) is a transistor that uses an electric field to control the flow of current, which incorporates a junction between two materials with different band gaps where electron states cannot exist. HEMTs have high power performance and can operate at higher frequencies up to millimeter wave, which is attractive for power electronics such as cell phones, T...

Projection System for Visual Morphing of Patient Disease

technology@sc.edu — Thu, 13 May 2021 08:31:20 GMT

Reference #: 01430 The University of South Carolina is offering licensing opportunities for Projection System for Visual Morphing of Patient Disease Background: Many patients fail to truly understand the implications of their condition. They sometimes neglect how their disease can progress and thus do not prioritize their medications and needed lifestyle changes. This can lead to patients not being adequately motivated to take better care of themselves and being compliant with prescribed medical regimens. Invention Description: The invention is a patient education tool con...

TGFbeta1 Hyperactivation Causes Gender-Specific Calcific Aortic Stenosis

technology@sc.edu — Thu, 13 May 2021 08:27:16 GMT

Reference #: 01427 The University of South Carolina is offering licensing opportunities for TGFbeta1 hyperactivation causes gender-specific calcific aortic stenosis Background: Calcific aortic valve disease (CAVD) affects 25% of the population over 65 years of age. The CAVD is a progressive disease ranging from aortic valve (AoV) sclerosis, which is the stiffening of the heart valves being replaced with scar tissue, to AoV stenosis (AS) which is the narrowing of heart valves. In the first phase of the disease, termed aortic sclerosis, the valve becomes thickened and mildly calcifi...

Self-Driving Date Car

technology@sc.edu — Thu, 13 May 2021 08:25:40 GMT

Reference #: 01424 The University of South Carolina is offering licensing opportunities for a Self-Driving Date Car Background: Most automobile manufacturers are currently involved in developing self-driving cars. Billions of dollars are being spent every year and the technology is progressing rapidly. Rideshare companies are also surpassing traditional taxi services and taking over the market. Companies such as Uber are working towards autonomous rideshare vehicles as a means of cost-effective transport. Invention Description: This invention combines self-driving automobi...

Structurally Tunable Highly Stable PtNiCeSi Based Catalysts Methane Reforming

technology@sc.edu — Thu, 13 May 2021 08:24:59 GMT

Reference #: 01423 The University of South Carolina is offering licensing opportunities for Structurally tunable highly stable PtNiCeSi based catalysts methane reforming Background: Municipal Solid Waste generation in the USA is EPA estimated at 250 million tons. with almost thirty percent of it going uncollected. Waste treatments include landfills, recycling, and energy recovery facilities. Because of the presence of organic content in the landfilled waste, landfill gas and leachate are generated by microorganisms in the process of breaking down this waste. Almost half of the com...

Novel Pharmaceutical for Prevention of Bleomycin-Induced Pulmonary Fibrosis

technology@sc.edu — Thu, 13 May 2021 08:24:12 GMT

Reference #: 01409 The University of South Carolina is offering licensing opportunities for Novel Pharmaceutical for Prevention of Bleomycin-Induced Pulmonary Fibrosis Background: Hodgkin’s lymphoma is one of the curable cancers and the standard treatment regimen involves combination chemotherapy involving bleomycin. One of the fatal side effects of bleomycin is pulmonary toxicity. In three tested cases of Hodgkin’s lymphoma treated with ABVD chemotherapy who had pulmonary toxicity, all three developed bleomycin-induced pulmonary toxicity in the form of pulmonary fibro...

Vibration Test-cell With Axial Load and In-situ Microscopy

technology@sc.edu — Thu, 13 May 2021 08:17:35 GMT

Reference #: 01382 The University of South Carolina is offering licensing opportunities for vibration test-cell with axial load and in-situ microscopy. Background:The test cell enables understanding the micro-fracture events during fatigue crack vibrations. Invention Description:The test cell is comprised of four subparts: mechanical load frame, mechanical shaker, optical microscope, and acoustic emission measurement. Each of the subparts can operate independently with each other, which makes it versatile and useful. Potential Applications:This product can help...

Composite Uranium Silicide-Uranium Dioxide Nuclear Fuel

technology@sc.edu — Thu, 13 May 2021 08:14:43 GMT

Reference #: 01312The University of South Carolina is offering licensing opportunities for Composite uranium silicide-uranium dioxide nuclear fuel. Background:The advantages of nitride fuel are high thermal conductivity, very high melting point, and high density. These benefits have long been recognized. The sodium cooled BR-10 reactor in Russia operated for 18 years on uranium nitride fuel, used as the driver fuel for two core loads. The potential advantages of a light water reactor are a large power up-grade, increased cycle lengths, and possible high burn-up. However, the a...

Methods for Encoding and Decoding based on Partitioned Complementary Sequences

technology@sc.edu — Tue, 11 May 2021 07:50:04 GMT

Reference #: 01512 The University of South Carolina is offering licensing opportunities for Methods for Encoding and Decoding based on Partitioned Complementary Sequences Background: Orthogonal frequency division multiplexing (OFDM) waveform utilized in 4G, 5G, and Wi-Fi has peaky signal characteristics. Hence, the waveform is often distorted under a non-linear power amplifier of a practical radio. To avoid this distortion, either the transmit power is reduced, i.e., a shorter communication range, or an expensive power amplifier is employed at the radio to handle the large instantaneous pea...

Experimental Set Up For Studying Temperature Gradient Driven Cracking

technology@sc.edu — Mon, 10 May 2021 12:43:48 GMT

Reference #: 01509 The University of South Carolina is offering licensing opportunities for Experimental Set up for Studying Temperature Gradient driven cracking Background: The behavior of light water reactor (LWR) fuel is significantly affected by fracture, which is driven by multiple phenomena. Early in the life of fresh fuel, fracture is primarily caused by thermal stresses. The fission process in the cylindrical fuel pellets causes volumetric heating that in conjunction with the forced convective cooling on the exterior of the fuel rod results in a temperature profile with significantl...

Electrochemical Dehydrogenation of Ethane to Ethylene using Solid Oxide Electrolyzer

technology@sc.edu — Mon, 10 May 2021 12:40:17 GMT

Reference #: 01508 The University of South Carolina is offering licensing opportunities for Electrochemical Dehydrogenation of Ethane to Ethylene using Solid Oxide Electrolyzer Background: Ethylene is typically produced from natural gas liquid where ethane is the main component. The current industrial method to produce ethylene from ethane is through ethane steam cracking process which is energy intensive and emits significant amount of CO2. Thermal catalysis of ethane to ethylene has the limitations of low yield and catalyst deactivation. Invention Description: This invention uses...

A Direct Methane Fueled Thin Film SOFC Technology

technology@sc.edu — Mon, 10 May 2021 11:46:38 GMT

Reference #: 01501 The University of South Carolina is offering licensing opportunities for A Direct Methane Fueled Thin Film SOFC Technology Background: Fuel flexibility is an attractive advantage of solid oxide fuel cell (SOFC) technology; however, carbon deposition issue with widely used Ni-cermet anodes in hydrocarbon fuels seriously limits its long-term stability. While alternative anode materials have been developed to overcome this issue, none of these materials demonstrates electronic conductivity and (electro) catalytic activity that can compete earlier versions of this technology....

In Vitro Assay For Drug Discovery of Valvular Heart Disease

technology@sc.edu — Mon, 10 May 2021 11:31:39 GMT

Reference #: 01499 The University of South Carolina is offering licensing opportunities for In vitro assay for drug discovery of valvular heart disease Background: Heart valve disease is the third leading cause of heart disease. Calcification of aortic valve and mitral valve is a major heart valve disease. There is no medical treatment, and the surgical valve replacement is the only option to save patients' lives. Unfortunately, replaced valves could further calcify after few years requiring further valve replacement surgery. Invention Description: The proposed is a cell culture-based...

Lebesgue-sampling-based battery whole-service-life SOC estimation using simplified first principle model

technology@sc.edu — Mon, 10 May 2021 09:28:12 GMT

Reference #: 01493 The University of South Carolina is offering licensing opportunities for Lebesgue-sampling-based battery whole-service-life SOC estimation using simplified first principle model Background: Traditional state of health and state of charge estimation is mainly based on the electrochemical model or equivalent circuit model of Li-battery. The electrochemical model can describe the internal electrochemical reaction mechanism of Li-battery accurately, but the computation is high, which hinders embedded applications. On the contrary, computation of the equivalent circuit model i...

Solver Creation Tools for Power Electronic System Real-Time Simulation

technology@sc.edu — Mon, 10 May 2021 09:14:44 GMT

Reference #: 01492 The University of South Carolina is offering licensing opportunities for Software and Synthesis Development Libraries for Power Electronic System Real-Time Simulation Background: In the development of power electronic ships, is often required to perform Real-Time (RT) and hardware-in-the-loop (HIL) simulations of these systems to prototype and validate the design of the system before physical construction. Modern ship systems are expected to make large use of high switching frequency power electronic converters. For reliable simulation of such high switching frequency pow...

Synthesize Effective Ensemble Based Dynamic Defenses to Adversarial Attacks

technology@sc.edu — Mon, 10 May 2021 09:01:28 GMT

Reference #: 01490 The University of South Carolina is offering licensing opportunities for Synthesize Effective Ensemble Based Dynamic Defenses to Adversarial Attacks Background: A lot of learning-based AI techniques are very prone to adversarial attacks. However, these attacks are detectable and there are algorithms that can defend against adversarial attacks. These existing defenses to attacks do not change at deployment time. It is possible to introduce “ensemble-based defenses”. Invention Description: The proposed invention is an ensemble-based defense for learning...

Motor Winding Insulation Diagnosis and Prognosis Using Resistance Simulation Method

technology@sc.edu — Mon, 10 May 2021 08:31:40 GMT

Reference #: 01489 The University of South Carolina is offering licensing opportunities for Motor winding insulation diagnosis and prognosis using resistance simulation method Background: The purpose of building Permanent Magnet Synchronous Motor (PMSM) model is to enable the winding insulation fault injection in motor, along with fault (clogging) in filter, to establish a multi-dimensional environment that can be used in automated contingency management development. This enables the maturity of the dynamic simulation-based ACM system for life support systems and integration of diagnosis, p...

Immune CB1 Activation for Obesity Therapy

technology@sc.edu — Fri, 07 May 2021 12:23:41 GMT

Reference #: 01478 The University of South Carolina is offering licensing opportunities for Immune CB1 activation for obesity therapy Background: The endocannabinoid system regulates various physiological processes such as inflammation and metabolism, and is comprised of cannabinoid receptors, CB1 and CB2, as well as their ligands called endocannabinoids. Overactivation of CB1 is characteristic of obesity. Nearly 40% of the world population is considered overweight or obese. Invention Description: Blocking CB1 receptors throughout the body promotes weight loss, although side effects on t...

Methods for Wideband Index Modulation Based on Chirp Signals

technology@sc.edu — Fri, 07 May 2021 12:19:02 GMT

Reference #: 01476 The University of South Carolina is offering licensing opportunities for Methods for Wideband Index Modulation based on Chirp Signals Background: Chirp can provide robustness against distortions due to the non-linear components in a radio-frequency chain, for example a non-linear power amplifier. They also provide good correlation properties. Hence, they are useful for both radar and communication applications. One of the challenges with using the multiple chirp signals for communications is that the peak-to-mean-envelope-power ratio (PMEPR) can be high when multiple chir...

Laser-Based Non-Destructive Spike Defect Inspection System

technology@sc.edu — Fri, 07 May 2021 12:13:58 GMT

Reference #: 01473 The University of South Carolina is offering licensing opportunities for Laser-based Non-destructive Spike Defect Inspection System Background: Although many new types of elastic fasteners and concrete ties have been introduced recently, cut spikes (referred as spike hereafter) together with tie plates and timber ties are the dominant track components in North America freight railroads. For centuries, spikes, with marginal changes in terms of geometry and material, have been consistently providing reliable restrictions to rails. Spikes have also been used to fix tie plate...

Extremely Large Pressure Swing Adsorption Processes for Flue Gas Treatment

technology@sc.edu — Fri, 07 May 2021 12:04:12 GMT

Reference #: 01469 The University of South Carolina is offering licensing opportunities for Extremely Large Pressure Swing Adsorption Processes for Flue Gas Treatment Background: Extremely large gas flow rates, like that associated with flue gas produced from a 550 MW coal fired power plant, can exceed 25,000,000 SLPM. Even larger flue gas flow rates can be produced from steel mills. The flue gas produced from these processes is at a pressure slightly above about 100 kPa and a temperature between ambient and 125 oC. However, an issue arises with these low-pressure flue gas streams when fed ...

Computer Vision Based Real-Time Pixel-Level Railroad Track Components Detection System

technology@sc.edu — Fri, 07 May 2021 11:55:15 GMT

Reference #: 01467 The University of South Carolina is offering licensing opportunities for Computer vision based real-time pixel-level railroad track components detection system Background: Rail inspection is the practice of examining railroads for flaws that could lead to catastrophic failures. This process takes a lot of time and is typically done using either visual inspection in person or with cameras. Current approaches are two steps, which separate inspection video collection and data analysis. Invention Description: The proposed invention is a real-time segmentation...

A Gene to Transcriptome Association Platform for Drug Target Identification

technology@sc.edu — Fri, 07 May 2021 11:46:14 GMT

Reference #: 01465 The University of South Carolina is offering licensing opportunities for A Gene to Transcriptome Association platform for drug target identification Background: Data accumulation through genomic and transcriptomic analyses require novel tools/strategies for the extraction of biologically relevant and clinically useful information. A major limitation of existing approaches is that they focus on the magnitude of differential expression between groups, a strategy that is restricted when specimens from human, genetically diverse populations are studied. We developed a strateg...

Targeting Treatment For ADAM30 In Pathological Cells

technology@sc.edu — Fri, 07 May 2021 11:43:38 GMT

Reference #: 01462 The University of South Carolina is offering licensing opportunities for Targeting treatment for ADAM30 in pathological cells Background: The treatment options for vascular malformations include conservative management, drug treatment, interventional radiology, laser therapy, excisional surgery and psychological treatment. However, due to their complexity of types of blood vessels involved and severity of symptoms, proper diagnosis and managements are difficult and prognosis varies, which is a major challenge and threat to public health. Early diagnosis of some congenital...

Exosome-Delivered Targeting Treatment for Blood Vessels

technology@sc.edu — Fri, 07 May 2021 11:31:59 GMT

Reference #: 01455 The University of South Carolina is offering licensing opportunities for exosome-delivered targeting treatment for blood vessels Background: Vascular malformations cause a variety of severe symptoms, depending on body location and types of vasculatures involved, which makes clinical management very challenging. The treatment options for vascular malformations are limited due to their complexity of types of blood vessels involved and severity of symptoms. Proper diagnosis and managements are difficult, and prognosis varies, which is a major challenge and threat to public h...

Biomarkers for Congenital Vascular Malformations

technology@sc.edu — Fri, 07 May 2021 11:29:45 GMT

Reference #: 01454 The University of South Carolina is offering licensing opportunities for Biomarkers for congenital vascular malformations Background: Vascular Malformations ae blemishes or masses on the body that may cause pain, swelling, or bleeding. VMs result from abnormal development in blood vessels, lymph vessels, or arteries, and are rare and complex. The overall incidence of congenital vascular malformations in general population is about 1.5%, which is about 4.8 million patients in U.S. and 105.5 million patients worldwide as the direct targeting population. In addition, it can ...

Acoustic Emission Method to Ascertain Damage Occurrence in Impacted Composites

technology@sc.edu — Tue, 04 May 2021 13:39:33 GMT

Reference #: 01448 The University of South Carolina is offering licensing opportunities for Acoustic emission method to ascertain damage occurrence in impacted composites Background: In CFRP composites manufacturing flaws and operational damage are inevitable and need to be detected for quality assurance. In-service damage of CFRP structures is also possible; such damage may be barely visible damage (BVD); this in-service damage is hard to detect but may strongly affect the service life. It is imperative to detect these defects at the earliest to avoid catastrophic failures of these structu...

A High Capacity Bilayer Cathode for Aqueous Zn-ion Batteries

technology@sc.edu — Tue, 04 May 2021 13:31:26 GMT

Reference #: 01447 The University of South Carolina is offering licensing opportunities for A High Capacity Bilayer Cathode for Aqueous Zn-ion Batteries Background: Zinc ion batteries (ZIBs) use zinc ions as the working charge carriers and zinc metal as the anode. The cathodes typically used are MnO2 and V2O5 based layered materials. Aqueous ZIBs are promising candidates for grid-scale energy storage because they are intrinsically safe, cost competitive and energy intense. Large-scale energy storage (LSES) technologies are critical for a deeper and broader penetration of renewable energy in...

Carrier-Free Curcumin Nanoparticle for EGFR Positive Cancer Therapy

technology@sc.edu — Fri, 12 Mar 2021 10:59:36 GMT

Reference #: 01472 The University of South Carolina is offering licensing opportunities for Carrier-free curcumin nanoparticle for EGFR positive cancer therapy Background: Due to their small size and large surface area, drug nanoparticles show great promise in improving drug delivery in patients. Invention Description: Most nanoparticle based drug delivery systems are composed of a carrier and a payload. However, due to the low drug loading content, premature drug release, non-standardized or uniform carrier structure, and difficulty in predicating the fate of the carrier, only a f...

3D Printed Water Cooled Tow Guide for Fiber Placement Machine

technology@sc.edu — Fri, 12 Mar 2021 10:56:31 GMT

Reference #: 01464 The University of South Carolina is offering licensing opportunities for 3D Printed Passive Heat Exchanging Tow Guide with for Fiber Placement Machine Background: This invention solves a problem with Automated Fiber Placement (AFP) with thermoplastic tape materials. Presently, AFP with thermoplastics such as PEEK, PAEK, require use of high-power laser heating systems. The temperature required to heat this material enough to manufacture is 700-900 degrees Fahrenheit. This temperature is too high for standard tow guides (scoops), and thus the heat must be concentrated to a ...

Method to Produce High Densities of Isolated Atoms on Support Substrates

technology@sc.edu — Fri, 12 Mar 2021 10:02:56 GMT

Reference #: 01511 The University of South Carolina is offering licensing opportunities for Method to Produce High Densities of Isolated Atoms on Support Substrates Background: Useful chemicals are widely synthesized by homogeneous transition metal-catalyzed reactions. However, the aggregation and precipitation of atomically dispersed catalysts causes considerable loss of activity. This has spurred interest in the heterogenization of atomically dispersed catalysts to impart stability and facilitate recyclability. The current synthesis methods are not scalable and do not yield a high density...

Angle-Beam Guided Waves for Composite-Damage Identification and Monitoring

technology@sc.edu — Fri, 12 Mar 2021 10:01:37 GMT

Reference #: 01446 The University of South Carolina is offering licensing opportunities for Angle-beam guided waves for composite-damage identification and monitoring Background: In composites, manufacturing flaws and operational damage are inevitable and need to be detected for quality assurance. In-service damage of composite structures is also possible; such damage may be barely visible impact damage. This in-service damage is hard to detect but could strongly affect the service life. It is imperative to detect these defects at the earliest possible time to avoid catastrophic failures ...

Cell-based Biosensor for Early Alzheimer's Disease Detection

technology@sc.edu — Fri, 12 Mar 2021 09:39:47 GMT

Reference #: 01442 The University of South Carolina is offering licensing opportunities for Cell-based biosensor for early Alzheimer's disease detection Background: Alzheimer’s disease is the 6th leading cause of death in the United States. Early Alzheimer’s disease detection is needed for effective therapy due to the irreversible death of neurons. Alzheimer’s disease is characterized by deposition of amyloid-beta protein in the brain, and thus the amyloid-beta protein has been proposed as a disease biomarker. However, early detection of this biomarker has proven ineff...

Methods for Non-linear Distortion Immune End-to-End Learning with Autoencoder-OFDM

technology@sc.edu — Fri, 12 Mar 2021 09:39:15 GMT

Reference #: 01441 The University of South Carolina is offering licensing opportunities for Methods for Non-linear Distortion Immune End-to-End Learning with Autoencoder-OFDM1 Background: AI-based communication systems utilize machine learning modules (e.g., deep learning) to replace the functionality of the highly engineered blocks (e.g., coding, modulation, waveform, etc) in the physical layer of communication systems. However, the machine learning methods in the field of computer vision may not be directly applied to the communication systems as a communication system may encounter diffe...

Steel Mesh Based Catalyst With Superior Mechanical Stability / Magnetic Separability

technology@sc.edu — Fri, 12 Mar 2021 09:27:47 GMT

Reference #: 01440 The University of South Carolina is offering licensing opportunities for Steel mesh-based catalysts with superior mechanical stability and magnetic separability. Background: Torrefaction is a thermal process to convert biomass into a coal-like material, which has better fuel characteristics than the original biomass. During the torrefaction of biomass, large amounts of toxic CO can be produced (up to 3-4vol%). A steel mesh-based catalyst can be utilized to form CO2 and H2 (a value-added product) from CO and H2O in addition to oxidizing CO with O2. The catalyst can be se...

Methods for Reliable Chirp Transmissions

technology@sc.edu — Fri, 12 Mar 2021 09:24:10 GMT

Reference #: 01439 The University of South Carolina is offering licensing opportunities for Methods for Reliable Chirp Transmissions and Multiplexing Background: To increase the reliability and security of communication systems the communication link must be established over multiple bands, e.g., L-Band (1-2 GHz) and C-Band (4-8 GHz) for aeronautical networks. On the other hand, simultaneous use of multiple bands can cause large instantaneous power fluctuations at the input of the power amplifier of the radios due to the constructive or destructive additions of the signals on different band...

Implantation Success as Determined by Blastocoel Fluid Components

technology@sc.edu — Tue, 17 Dec 2019 12:11:22 GMT

Reference #: 01340The University of South Carolina is offering licensing opportunities for Implantation Success as Determined by Blastocoel Fluid Components. Background:Currently, embryos are assessed solely for chromosomal status (euploid or aneuploid) following IVF. Only those embryos determined to be euploid are then subsequently transferred. However, not all euploid embryos transferred will successfully implant or develop full-term. Invention Description:Analysis of the contents within the blastocoel cavity (i.e. blastocoel fluid) of embryos can provide a molecular signature tha...

Sensing in Tires for Rolling Resistance

technology@sc.edu — Tue, 17 Dec 2019 07:45:35 GMT

Reference #: 01383The University of South Carolina is offering licensing opportunities for Sensing in Tires for Rolling Resistance. Background:According to the Alternative Fuels Data Center, an estimated 5% to 15% of passenger car fuel consumption is used to overcome rolling resistance.Rolling resistance includes mechanical energy losses due to aerodynamic drag associated with rolling, friction between the tire and road and between the tire and rim, and energy losses taking place within the structure of the tire.Due to the weight of a vehicle, the bottom part of a tire flattens and as it ...

Flow Velocimetries Based on Laser Induced Fluorescence Photobleaching

technology@sc.edu — Tue, 17 Dec 2019 07:11:18 GMT

Reference #: 01351The University of South Carolina is offering licensing opportunities for Flow Velocimetry based on laser induced fluorescence photobleaching. Background:Transport phenomena (fluid mechanics, heat transfer, mass transfer) play a key role for the performance of micro/nanofluidic devices. To understand the transport phenomena, one needs to measure the flow velocity profile first. Most velocimeters in micro/nanofluidics rely on flow tracer particles, such as micro Particle Image Velocimetry (μPIV). Particle Image Velocimetry is an optical method of visualizing the instant...

Hyperspectral Imaging Spatial Heterodyne Raman Spectrometer Using a Microlens Array

technology@sc.edu — Wed, 20 Nov 2019 12:24:28 GMT

Reference #: 01402 The University of South Carolina is offering licensing opportunities for Hyperspectral Imaging Spatial Heterodyne Raman Spectrometer Using a Microlens Array Background: Raman spectroscopy is used to observe vibrational, rotational, and other low-frequency modes in a system and is common technique used in chemistry to provide a structural fingerprint by which molecules can be identified. Raman imaging is the practice of generating detailed chemical images based on a sample’s Raman spectrum. A complete spectrum is acquired at each and every pixel of the imag...

Siloxane Removal Off Landfill Gas Using Dielectric Barrier Discharge Plasma

technology@sc.edu — Mon, 28 Oct 2019 06:11:40 GMT

Reference #: 01437 The University of South Carolina is offering licensing opportunities for Siloxane Removal off Landfill Gas Using Dielectric Barrier Discharge Plasma Background: U.S. regulations have set a target of generating 25% of the energy from renewable sources by 2025, which is also a prime motivation of using LFG (Landfill Gas) as an alternative energy source. However, LFG usage is hindered due to the presence of even trace siloxane(s) as contaminants. Siloxane compounds are detrimental to engines if these undergo combustion within a fuel mixture. Over extended periods o...

A Reconfigurable Antenna Design for Centimeter-Wave and Millimeter-Wave

technology@sc.edu — Mon, 28 Oct 2019 06:00:33 GMT

Reference #: 01431 The University of South Carolina is offering licensing opportunities for a Reconfigurable Antenna Design for Centimeter-Wave and Millimeter-Wave Background: 5G Networks are the future of mobile device connectivity and will greatly improve cell network speeds. In order to implement the newer technology, the antennas must have spectrum flexibility, which is the ability to operate at a wide range of spectrums, from centimeter-wave to millimeter-wave. 5G New Radio specifications have already standardized PHY/MAC protocols for dual operations on cmWave and mmWave. To...

Mixed Mode-(I/III) Dynamic Fracture Toughness

technology@sc.edu — Thu, 24 Oct 2019 13:28:01 GMT

Reference #: 01422 The University of South Carolina is offering licensing opportunities for Mixed Mode-(I/III) Dynamic Fracture Toughness Background: Measuring the fracture toughness of materials under high load conditions has been a topic of interest in mechanical and material science communities in the last four decades. So far, no standard method can be used to estimate the dynamic fracture properties for engineering materials that are subjected to a critical load, such as nuclear pressure or airplanes. Invention Description: This invention is a unique method to measure the f...

Natural Compounds for Modulation of Cell Secretome Production and Composition

technology@sc.edu — Thu, 24 Oct 2019 13:18:24 GMT

Reference #: 01421 The University of South Carolina is offering licensing opportunities for Natural Compounds for Modulation of Cell Secretome Production and Composition Background: Plants are the oldest source of natural compounds with medicinal and cosmetic properties explored by the world. 11% of the existed essential drugs used in modern human medicine are still of plant origin. There is an increasing number of studies showing positive effects of condition media (secretome) with secreted proteins derived from various stem cells in tissue regeneration confirming the hypoth...

Co-electroless Deposition Methods for Formation of Methanol Fuel Cell Catalysts

technology@sc.edu — Thu, 24 Oct 2019 09:44:05 GMT

Reference #: 01408 The University of South Carolina is offering licensing opportunities for Co-electroless Deposition Methods for Formation of Methanol Fuel Cell Catalysts Background: Methanol is an alternative fuel for internal combustion engines that can be used in combination with gasoline or directly. Methanol burns at lower temperatures than gasoline, having lower energy content than gasoline subsequently requiring more fuel consumption than typical hydrocarbon fuels. The ability to prepare a wide range of platinum-containing bimetallic catalysts using co-electroless dep...

Spindle Assembly Checkpoint Inhibition for Treatment of p53 Deficient Cancers

technology@sc.edu — Thu, 24 Oct 2019 09:25:19 GMT

Reference #: 01405 The University of South Carolina is offering licensing opportunities for Re-sensitizing p53-null Stem Cells with Spindle Assembly Checkpoint Inhibition Background: TP53 is one of the most well-studied tumor suppressor genes and is known to be pivotal in response to DNA damage for cell cycle arrest, deterioration with age, or cell death. The TP53 gene is the most commonly mutated gene across all cancers. The product of the TP53 gene is a sequence-specific DNA binding protein (p53) that regulates gene transcription. Targeting this gene directly is difficult with p...

The Preparation of Dual-Targeted Nano-Cocktail and its Application in Cancer Therapy

technology@sc.edu — Thu, 24 Oct 2019 09:07:41 GMT

Reference #: 01404 The University of South Carolina is offering licensing opportunities for Preparation of Dual-Targeted Nano-Cocktail and its Application in Cancer Therapy Background: Due to the heterogeneous nature of tumors and the limitation of anticancer drugs, a mono-compound treatment usually can only kill a fraction of cancer cells while sparing non-responsive ones, which can continue proliferating and result in the recurrence of cancer. A nano-cocktail can be used to treat multiple kinds of cancer cells and works by creating a cooperative nanosystem of different treatment...

Inhibitors of Glucose Kinases: Update 2-27-2019

technology@sc.edu — Thu, 24 Oct 2019 09:01:42 GMT

Reference #: 01401 The University of South Carolina is offering licensing opportunities for Monosaccharide Amine and 3-Nitro-2-Phenyl-2H-Chromene Based Inhibitors of Glucose Kinases Background: When a kissing bug bites a human, they can be infected with a Kinetoplastid parasite such as Trypanosoma cruzi (T. cruzi). A need exists for new drugs that strongly bind to drug targets found in these parasites. Such a need includes inhibitors of the glucose kinase enzymes, which include hexokinase and/or glucokinase. These enzymes produce the product glucose-6phosphate (G6P), which acts as...

Methods and Compositions for Modulating the WNT-Signaling Pathway as Treatments for Inflammatory Diseases

technology@sc.edu — Thu, 24 Oct 2019 09:00:23 GMT

Reference #: 01371 The University of South Carolina is offering licensing opportunities for IWR1 as an Immunosuppressant and Anti-inflammatory Agent Background: Posttraumatic Stress Disorder (PTSD) is a psychiatric disorder accompanied by chronic peripheral inflammation. It is currently unclear what triggers inflammation in PTSD. In the present study, we used an RNA-seq screening analysis of Peripheral Blood Mononuclear cells (PBMCs) from healthy control patients and PTSD patients and found that the Wnt signaling pathway was unregulated in PTSD. Specifically, we found a...

Gel-within-Gel Dressing for Wound Debridement

technology@sc.edu — Thu, 24 Oct 2019 08:57:22 GMT

Reference #: 01364 The University of South Carolina is offering licensing opportunities for Gel-within-Gel Dressing for Wound Debridement Background: Keeping wounds moist is beneficial for wound healing. Additionally, several growth factors in wound exudates are good for healing. Therefore, various kinds of wound dressings are being developed. Many wound dressings have been developed to try to both protect the healing wound from infection and also to help promote the wound healing process itself. A moist occlusive dressing helps support the inflammatory phase and also increases th...

pH-Indicating Swabs for Wound Biomonitoring and Diagnostics

technology@sc.edu — Thu, 24 Oct 2019 08:54:34 GMT

Reference #: 01362 The University of South Carolina is offering licensing opportunities for pH-Indicating Swabs for Wound Biomonitoring and Diagnostics Background: Current methods of assessing an infected wound are outdated, subjective, and inaccurate. They are based primarily on assaying for a variety of parameters associated with the wound. For instance, a wound may be assessed visually, length and depth measurements may be taken, and digital photography may be used where available to track the visual condition and size of a wound. In clinical practice, diagnosis of infection is...

Method for Intelligent Load Management in Off-Grid AC Systems

technology@sc.edu — Wed, 23 Oct 2019 12:52:46 GMT

Reference #: 01356 The University of South Carolina is offering licensing opportunities for Method for Intelligent Load Management in off-grid AC Systems Background: In an off-grid application, available power is limited and the total load power exceeds the maximum power generation capability. Therefore, it becomes important to manage and prioritize loads based on current system status. This is similar to demand response in grid systems. Additionally, if energy storage is available, the battery state of charge must be managed: the battery should act as a power source when power de...

Enzymatically Cleavable Self Assembled Nanoparticles for Morphogen Delivery

technology@sc.edu — Wed, 23 Oct 2019 12:42:29 GMT

Reference #: 01350 The University of South Carolina is offering licensing opportunities for Enzymatically Cleavable Self-Assembled Nanoparticles for Morphogen Deliver Background: There is a continuing need to develop approaches for controlled release of morphogens, which control cell shape, in applications such as tissue regeneration. While metal and ceramic particles have been used as delivery systems, these materials can have drawbacks because even though they are biocompatible, there is a risk for accumulation in the body, something that may be a particular issue when the site ...

In-Contact Continuous Temperature Measurement Probe for Non-Insulated Electric-Current Carrying Conductor

technology@sc.edu — Wed, 23 Oct 2019 12:25:40 GMT

Reference #: 01349 The University of South Carolina is offering licensing opportunities for In-contact Continuous Temperature Measurement Probe for Non-insulated Electric-Current Carrying Conductor Background: Reliable, Safe and Quick temperature measurement of/around the surface of electric current carrying lines/objects/heater is a significant aspect in heat transfer study and in household applications. Currently, there are no probes that can measure in-contact temperature of the current flowing in a conductive pipe/rod without any insulation. This poses a high risk o...

Compositions and Methods for Inducing a Treg Phenotype and Methods for Use for the Same

technology@sc.edu — Wed, 23 Oct 2019 12:20:01 GMT

Reference #: 01346 The University of South Carolina is offering licensing opportunities for Compositions and Methods for Inducing a T-reg Phenotype and Methods for Use for the Same Background: The T cell phenotype is important for controlling the immune response generate due to different stimuli. Viral infection requires the generation of killer “T cells” that can destroy infected cells. T cells are necessary to combat these infections, but the T cell response can pose problems with activated against non-pathogenic tissue, such as in autoimmune diseases or transplant r...

Dot Blot Box for Detection of Blotted Protein

technology@sc.edu — Wed, 23 Oct 2019 08:46:32 GMT

Reference #: 01271 The University of South Carolina is offering licensing opportunities for Dot Blot Box for Detection of Blotted Protein Background: The cause of Alzheimer’s disease is believed to lie within the aggregation and subsequent accumulation of the amyloid-b (Ab) protein. Observation of amyloid-b aggregation requires readings or assessments at many time points, and Thioflavin-T (ThT fluorescence techniques are frequently used to observe this aggregation phenomenon. However, many of the potential inhibitors of Ab aggregation investigated in this la...

Synthesis of Metal Oxynitrides Using Flame Spray Pyrolysis

technology@sc.edu — Wed, 23 Oct 2019 08:29:19 GMT

Reference #: 01393 The University of South Carolina is offering licensing opportunities for synthesis of metal oxynitrides. Background: Current synthesis methods for metal oxynitrides are often time consuming, non- industrially scalable, and occur in not well controlled environments. Flame spray pyrolysis has been shown to be a viable method of synthesizing metal oxynitrides. Flame synthesis is well known as a fast, industrially scalable technique in literature. Different aspects of the flame environment can be controlled including the temperature, the surrounding gas compo...

Transcranial Magnetic Stimulation as a Way to Treat Dysautonomia

technology@sc.edu — Tue, 27 Aug 2019 11:10:12 GMT

Reference #: 01400 The University of South Carolina is offering licensing opportunities for Transcranial Magnetic Stimulation as a Way to Treat Dysautonomia Background: The autonomic nervous system controls bodily functions that are not consciously directed. These functions include breathing, digestion, and heart rate. People with dysautonomia (abnormalities in the regulation provided by the autonomic nervous system) usually exhibit symptoms such as changes in the resting heart rate, breathing problems, and constipation. These symptoms are quite common, affecting approximately 70 ...

Iterative Feedback Motion Planning

technology@sc.edu — Mon, 12 Aug 2019 22:47:32 GMT

Reference #: 01394 The University of South Carolina is offering licensing opportunities for Iterative Feedback Motion Planning Background: In an autonomous driving system (ADS), the motion planning module is responsible for generating a motion trajectory for the motion controller. The motion controller module attempts to drive the vehicle while following the motion trajectory as closely as possible. Although a lot of advanced control methods such as using a linear quadratic regulator or model predictive controller improve the tracking performance, their effectiveness can be improv...

Quantum Dot Enhancement of Wide Bandgap Schottky Devices

technology@sc.edu — Fri, 26 Jul 2019 12:23:16 GMT

Reference #: 01392 The University of South Carolina is offering licensing opportunities for Quantum Dot Enhancement of Wide Bandgap Schottky Devices Background: Wide bandgap Schottky devices increase the efficiency of electronic devices such as LEDs, light sensors, and solar cells. Schottky devices are a superior diode with less heat production, less voltage loss, and the ability to handle higher frequencies of electric current than their silicon counterparts. Through the use of tiny semiconductor particles called “quantum dots” which emit light waves based on the...

Methods for Synthesizing Vanadium Oxide Nanobelts and Applications as Cathode Materials for Batteries

technology@sc.edu — Fri, 12 Jul 2019 14:46:01 GMT

Reference #: 01420 The University of South Carolina is offering licensing opportunities for a V3O8-layered structure as a cathode for zinc-ion batteries. Background: Battery-based energy storage technologies are critically important to existing grid stability and the increased use of renewable energy in the grid. The current state-of-the-art organic-based lithium-ion battery cannot be used for such large-scale application due to safety and cost concerns. Aqueous batteries have intrinsic safety, low cost and long life, and zinc-ion chemistry stands out to be the front runner. Howev...

Oxidation by Use of Electronic Atomic Monolayer-Metal Support Interaction Catalysts

technology@sc.edu — Fri, 12 Jul 2019 13:24:59 GMT

Reference #: 01414 The University of South Carolina is offering licensing opportunities for a Direct Oxidation of Methane to Methanol Catalyst Background: The increasing supply of natural gas and the resulting increased cost differential between natural gas and petrochemicals that can be derived from natural gas make the development of efficient heterogeneous catalysts for transforming methane into value-added fuels and chemicals an appealing proposition. Direct oxidation of methane to methanol with molecular oxygen is the economically preferred approach for valorizing methane rel...

Gas Separation Membranes From Polymer-Grafted Nanoparticles

technology@sc.edu — Fri, 12 Jul 2019 12:02:33 GMT

Reference #: 01418 The University of South Carolina is offering licensing opportunities for Gas Separation Membranes from Polymer-grafted Nanoparticles Background: Polymeric membranes are critical to many sustainability applications that separate gas mixtures based on size differences. Polymer blends using polymer grafted nanoparticles with small amounts (less than approximately 10%) of free polymer are used as membranes for gas separation.The challenge is primarily the need to selectively affect the transport of different mixture components while enhancing the membrane&rsquo...

Method to Make Isostructural Bilayer Cathodes

technology@sc.edu — Fri, 28 Jun 2019 09:26:06 GMT

Reference #: 01413 The University of South Carolina is offering licensing opportunities for a Method to Make Isostructural Bilayer Cathodes Background: The commercial development of solid oxide fuel cell (SOFC) technology in recent decades has primarily focused on how to lower the working temperature so that cost and reliability of SOFC can both be improved to meet the targets for practical applications, while still maintaining reasonable performance. The current benchmark cathodes, in general, have an insufficient rate of kinetics towards an oxygen reduction reaction (ORR) to yie...

Method for Tuning Surface Topography of Biocompatible, Injectable Polymer Particles

technology@sc.edu — Thu, 02 May 2019 08:22:28 GMT

Reference #: 01396 The University of South Carolina is offering licensing opportunities for Method for Tuning Surface Topography of Biocompatible, Injectable Polymer Particles Background:Polymer particles for drug delivery are made using an oil-in-water emulsion technique. Polymer particles are made to have rough surfaces, which impact their drug release characteristics and are expected to impact their cell and tissue interactions. Invention Description:This invention is the addition of a secondary emulsifier and a co-solvent to the oil phase that affords a system that mod...

System and Method for Early Detection of Colorectal Cancer

technology@sc.edu — Fri, 12 Apr 2019 10:42:59 GMT

Reference #: 01403The University of South Carolina is offering licensing opportunities for a system and method for early detection of colorectal cancer. Background:Colorectal cancer is the second leading cause of cancer deaths in both men and women. These cancers form from polyps located in the inner lining of the colon or rectum that have a two-thirds chance of being cancerous. As a result, most colorectal cancers grow slowly and do not show any symptoms, making them extremely hard to detect, though the cancer itself is preventable and curable if detected early. Unfortunately, only 39% o...

Laser Induced Graphitization and Diamond Coating of Boron Carbide

technology@sc.edu — Fri, 15 Mar 2019 09:31:44 GMT

Reference #: 01326 The University of South Carolina is offering licensing opportunities for Laser Induced Graphitization and Diamond Coating of Boron Carbide Background:Large-scale systematic creation and incorporation of graphene is currently slowed by the difficulties of its implementation into current processes, specifically electronic device fabrication. Invention Description:The localized formation of graphene and diamond like structures on the surface of boron carbide from exposure to high intensity laser illumination. The graphitization involves water vapor interacting w...

A Simple Method to Attach Pendant Groups to Polyvinyl Alcohol

technology@sc.edu — Fri, 15 Mar 2019 09:12:15 GMT

Reference #: 01391 The University of South Carolina is offering licensing opportunities for a simple method to attach pendant groups to polyvinyl alcohol Background: Currently, if you want to change the surface chemistry of the drug delivery particle you need to select a new emulsifier. In doing so, you may make unintended changes to the drug delivery system such as loading or release rate. Invention Description: This is a simple method to change the chemistry of a polymer widely used in paper making, textiles and a variety of coatings due to its excellent film fo...

Fabrication of Suramin-loaded Nanoparticle and its Application

technology@sc.edu — Fri, 15 Mar 2019 08:52:14 GMT

Reference #: 01386 The University of South Carolina is offering licensing opportunities for the fabrication of suramin loaded nanoparticle and its application. Background:Most anti-cancer drugs damage normal cells as they kill cancer cells, causing patients to suffer from side effects like heart tissue and kidney damage. It has been shown that suramin can protect the heart and kidneys from this damage. However, the half-life of suramin in the body is very short. Invention Description:A method to fabricate a suramin containing nanoparticle. Potential Applications...

A System and Method for Measuring Strain Using Reusable Marks

technology@sc.edu — Tue, 12 Mar 2019 10:03:13 GMT

Reference #: 01388 The University of South Carolina is offering licensing opportunities for a system and method for measuring strain using reusable marks. Background:The invention is a system method for measuring strain using reusable markers. The Center Dot is easy to apply to tensile specimens. This invention overcomes the limitation of conventional methods and provide full stress-strain curve break point with very accurate and repeatable measurements. Invention Description:This invention solves the problem of paint markers when used with high extensible materials. It a...

Swarm-Based Fire-Fighting

technology@sc.edu — Tue, 12 Mar 2019 09:37:24 GMT

Reference #: 01373 The University of South Carolina is offering licensing opportunities for Swarm-Based Fire-Fighting. Background:Wildfires extend over a large geographical area and proceed along several highly variable fronts simultaneously. Large fires often burn for weeks and cause billions of dollars of damage and cost hundreds of millions to fight. A variety of airborne vehicles are currently used to drop fire retardant, including Boeing 747s and helicopters. Invention Description:A method of using thousands of drones to deliver vastly superior amounts of fire retardant ove...

Apparatus for Detection of Molecule-Nanoparticle Interactions

technology@sc.edu — Wed, 27 Feb 2019 11:46:28 GMT

Reference #: 01344The University of South Carolina is offering licensing opportunities for an Apparatus for Detection of Molecule-Nanoparticle Interactions Background:Nanoparticles have widespread applications, from sensing to drug delivery, where much behavior is determined by the nature of the surface and the resulting intermolecular interactions with the local environment. Ligand mixtures enable continuously tunable behavior where both the composition and morphology influence molecular interactions. Nanoparticles have gained widespread interest for a wide array of applications suc...

Alkali-Activated Concrete

technology@sc.edu — Wed, 16 Jan 2019 14:08:33 GMT

Reference #: 01153 The University of South Carolina is offering licensing opportunities for Alkali-Activated Concrete. Background: Portland cement has traditionally been a vital material for the fabrication of concrete components. This paradigm may change in the future, however, as the production of cement requires a vast amount of energy while simultaneously releasing large amounts of CO2. To address these issues, alternative materials have been sought. Ideally, an alternative product will reduce or eliminate the Portland cement component of concrete while demonstrating equal o...

Novel Boron Nitride-Supported Pt-Ir Catalysts for Reduction of SO3

technology@sc.edu — Wed, 16 Jan 2019 11:24:20 GMT

Reference #: 01372 The University of South Carolina is offering licensing opportunities for Novel Boron Nitride-Supported Pt-Ir Catalysts for Reduction of SO3 Background: One of the most promising new technologies for green energy production is development of an economic method for the solar driven Hybrid Sulfur (HyS) process. The obstacle has been thermal instabilities of catalysts for the high temperature dissociation of SO3 to form SO2 and O2. Invention Description: This invention provides composition and methods directed to thermally stable catalyst systems, which...

Methods of Digital Image Correlation for Biological Samples

technology@sc.edu — Wed, 16 Jan 2019 06:49:50 GMT

Reference #: 01370 The University of South Carolina is offering licensing opportunities for Methods of Digital Image Correlation for Biological Samples Background: Digital image correlation (DIC) originally was developed at the University of South Carolina in the 1980s as a nondestructive technique to accurately measure small strains and deformations in engineering materials such as metals and ceramics. This technique relies on optically tracking displacements of a random, high-contrast “speckle pattern” on the specimen surface during loading. In comparison to ...

Pharmabiotic Approaches to Treat Phenylalanine Hydroxylase Deficiency

technology@sc.edu — Thu, 10 Jan 2019 11:13:10 GMT

Reference #: 01317The University of South Carolina is offering licensing opportunities for Pharmabiotic Approaches to Treat Phenylalanine Hydroxylase Deficiency Background:Approximately 1 in 15,000 persons in the US have phenylalanine hydroxylase deficiency. It is stated in the American College of Medical Genetics clinical practice guidelines for the treatment of the disorder that any intervention intended to lower blood phenylalanine levels should be considered appropriate therapy for this disease state. Current treatment strategies for phenylalanine hydroxylase deficiency include t...

Culture Medium for Human Skin Explants Enabling Molecular Studies

technology@sc.edu — Thu, 01 Nov 2018 11:55:56 GMT

Reference #: 01319The University of South Carolina is offering licensing opportunities for a culture medium for human skin explants that enables molecular studies. Background:The ability to work with human explants over a period of seven (7) days allowed researchers to validate findings obtained in a preclinical mouse model of eczema. This represents an important step towards translational research prior to the initiation of human studies. Invention Description:A culture medium was developed to maintain human skin biopsies in culture for up to seven (7) days. This medium allows for t...

Water Vapor Quantification Methodology During Drying of Spent Nuclear Fuel

technology@sc.edu — Thu, 01 Nov 2018 09:39:15 GMT

Reference #: 01367 The University of South Carolina is offering licensing opportunities for Water Vapor Quantification Methodology during Drying of Spent Nuclear Fuel Background:Spent fuel rods from nuclear reactors are initially kept in spent fuel pools to allow radioactivity to die away to levels that these rods can be stored in dry cask. After being transferred to the dry cask storage, the rods are sealed in a canister shrouded in inert gas and protected by an overpack of concrete that also serves as a radiation shield. The purpose of drying is to remove the water left in the cani...

Non-Invasive Estimation of the Mechanical Properties of the Heart

technology@sc.edu — Fri, 12 Oct 2018 10:16:41 GMT

Reference #: 01368The University of South Carolina is offering licensing opportunities for Non-Invasive Estimation of the Mechanical Properties of the Heart Background:Left ventricular remodeling, a mechanistic response to myocardial injury, has been shown to underlie the progression to heart failure. As such, sensitive technique to track the rate and extent of remodeling are necessary to evaluate risk and treatment options on a patient-specific basis. Echocardiography has become the gold standard for assessing the structure and function of the heart. Moreover, recent advancements in both...

Integrated and Automated Video/Structural Health Monitoring System

technology@sc.edu — Fri, 12 Oct 2018 09:16:34 GMT

Reference #: 01353The University of South Carolina is offering licensing opportunities for an Integrated and Automated Video/Structural Health Monitoring System Background:It is critically important to understand the source of structural health monitoring data in bridges and other structures, particularly (but not limited to) acoustic emission data, as the cause of the data is often not understood. Automated manufacturing has provided specific improvements in certain instances in quality, accuracy, and precision, but also can produce some negative consequences such as errors during manufa...

New Polar Oxysufide for Nonlinear Optical Applications

technology@sc.edu — Fri, 07 Sep 2018 11:37:06 GMT

Reference #: 01327The University of South Carolina is offering licensing opportunities for New Polar Oxysufide for Nonlinear Optical Applications Background:Non-linear optical materials are commonly used for frequency doubling diode-pumped solid state lasers such as Nd:YAG or other Nd-doped lasers, and are also used as optical parametric oscillator for near IR generation. They are also used as an electro-optic modulator, optical waveguide material, and in directional couplers. Invention Description:Synthesized single crystals of a new polar material that has an SHG response twice tha...

Macrocyclic Dimerization Inhibitors of Raf Kinases

technology@sc.edu — Fri, 07 Sep 2018 10:32:44 GMT

Reference #: 01338The University of South Carolina is offering licensing opportunities for Macrocyclic Dimerization Inhibitors of Raf Kinases. Background:Despite the clinical success of B-Raf inhibitors like vemurafenib in treating metastatic melanoma, resistance has emerged through “paradoxical MEK/ERK signaling” where rather than blocking cancer growth, tumor formation is stimulated. Tumors with mutant BRAF and also mutant RAS enzymes represent some of the deadliest forms of cancer, such as metastatic melanomas and pancreatic cancers. There is a huge unmet medical need in hu...

Ammonia Decomposition Catalyst

technology@sc.edu — Fri, 24 Aug 2018 12:40:46 GMT

Reference #: 01348 The University of South Carolina is offering licensing opportunities for an Ammonia Decomposition Catalyst. Background:Ammonia can be used as a hydrogen storage and transportation material. It is a carbon-free molecule with high hydrogen density that can easily be decomposed to produce hydrogen and nitrogen. For hydrogen production, it is necessary to perform the decomposition reaction at relatively low temperatures and high conversions to be integrated into a PEM fuel cell system. Invention Description:The discovery of new materials that act as catalysts to ...

Cumulus Cells Biomarkers for the Identification of Viable Embryos

technology@sc.edu — Fri, 10 Aug 2018 11:05:50 GMT

Reference #: 01355 The University of South Carolina is offering licensing opportunities for Cumulus Cells Biomarkers for the Identification of Viable Embryos Background:Human in vitro fertilization (IVF) generates embryos that can be transferred into the uterus to achieve pregnancy and live birth. IVF only results in live birth outcomes in about 50% of cycles because it is difficult to choose which of the generated embryos will result in live birth. The most common method for embryo selection is morphological appearance. Additionally, pre-genetic testing for normal chromosomal number...

Digested Decellularized Tissue as Microcarrier for Cell Culture and Expansion

technology@sc.edu — Thu, 09 Aug 2018 09:27:36 GMT

Reference #: 01345 The University of South Carolina is offering licensing opportunities for Digested Decellularized Tissue as Microcarrier for Cell Culture and Expansion Background:Cells in vivo reside within an interconnected 3D structure. Conversely, cells seeded on 2D culture plates or 3D suspended microbead- or microcarrier-based tissue culture are highly polarized, as part of the cell is firmly attached to the rigid surface of the plate/microcarrier while the rest of the cell is in contact with the culture medium. This polarization leads to cellular shock and stress which ...

In-situ Fiber Optic Temperature Field Measurement During Thermoplastic Composite Welding

technology@sc.edu — Wed, 01 Aug 2018 12:13:33 GMT

Reference #: 01310The University of South Carolina is offering licensing opportunities for In-situ Fiber Optic Temperature Field Measurement During Thermoplastic Composite Welding. Background:Thermoplastic composites are of growing interest in the aerospace sector due to their inherent properties. Their high toughness results in low-weight designs, and the physical process only involves melting without a curing cycle, which results in fast and robust processing. The usage of thermoplastic composites in aerospace primary parts is growing at an accelerated rate. In-situ measurement of ...

Enhanced Imaging for Quantification of Complex Discontinuity in Plate-like Structures

technology@sc.edu — Fri, 22 Jun 2018 09:32:25 GMT

Reference #: 01325The University of South Carolina is offering licensing opportunities for Enhanced Imaging for Quantification of Complex Discontinuity in Plate-like Structures Background:Structural health monitoring (SHM) and Nondestructive Evaluation (NDE) use ultrasonic guided waves (GW) supported by active sensor technology to interrogate structural components to assess damage, predict failure, expedite needed repairs, and increase the useful life of the components. Invention Description:Superior ultrasonic SHM/NDE synthetic imaging methods that can image significantly more compl...

New Generation of Lighting Phosphors based on stable Oxyflouride Host Lattice

technology@sc.edu — Thu, 07 Jun 2018 10:57:46 GMT

Reference #: 00969 Background:Research in solid-state lighting and in particular on new phosphor materials for white-light emitting diodes (LEDs) has become vitally important, because it can provide substantial energy savings and reduce global environmental impact. Phosphors are materials capable of emitting photoluminescence when excited by radiation. They are used in LEDs, cathode ray tubes (CRT) and sensors. LEDs are extensively used for applications in industrial and domestic lighting, indicator lights, traffic signs, automotive dashboards, and portable flash lights. Phosphors f...

Neutron Scintillating Materials

technology@sc.edu — Tue, 05 Jun 2018 09:52:28 GMT

Reference #: 00863 Background:Neutron detection and imaging has recently gained enormous importance in applications for homeland security, with particular emphasis on detecting explosives, radioactive materials, and materials associated with nuclear weapons – such as plutonium, which is a significant source of fission-based neutrons. The demand of homeland security has led to a shortage of 3He, which is used in the most common gaseous based neutron detector, because large scale radiation portal monitoring systems are being deployed by the thousands. Challenge...

Novel White Light Phosphors

technology@sc.edu — Tue, 05 Jun 2018 09:32:52 GMT

Reference #: 00702The University of South Carolina is offering licensing opportunities for this technology Background:Currently inefficient incandescent lighting (efficiency ~2%) is being replaced by fluorescent lighting (compact fluorescent lights CFL at an efficiency ~10%) to reduce our carbon footprint and be able to continue to use fossil fuels as raw materials for the chemical industry, where non-fossil alternatives are much more difficult to develop as viable economical alternatives. Invention Description:The subject invention is a self-activating phosphor Sr3AlO4-xF that...

Cold Sterilization of Tissue Engineering Scaffolds with Compressed Carbon Dioxide

technology@sc.edu — Mon, 04 Jun 2018 08:05:12 GMT

Reference #: 00774The University of South Carolina is offering licensing opportunities for this technologyInvention Description:A process for sterilizing tissue engineering materials by using compressed carbon dioxide into which selected additives have been incorporated. This method is effective for sterilizing complex structures, without causing adverse effects to the structure of the material.Potential Applications:This invention is extremely useful for sterilizing tissue engineering materials, including but not limited to synthetic polymers and natural polymers, without causing degradation ...

Creation and Characterization of TP53-null MCF7 Breast Cancer Cells

technology@sc.edu — Fri, 18 May 2018 10:17:49 GMT

Reference #: 01320The University of South Carolina is offering licensing opportunities for the Creation and Characterization of TP53-null MCF7 Breast Cancer Cells Background:Breast cancer is the most common cancer diagnosed among women, and the second leading cause of cancer death for women in the United States. 36.1% of breast cancers acquire a loss of function mutation to the tumor suppressor gene TP53, yet no therapies exist targeting the absence of p53. The MCF7 breast cancer cell line expresses a functioning wild type TP53 gene. CRISPR-Cas9 allows for accurate and precise engineering...

Analytical Global-Local (AGL) Prediction of Guided Wave Scattering from Discontinuities

technology@sc.edu — Fri, 18 May 2018 06:31:21 GMT

Reference #1324:The University of South Carolina is offering licensing opportunities for Analytical Global-Local (AGL) Prediction of Guided Wave Scattering from Discontinuities Background:The basic principle of using guided Lamb waves for damage detection in structural health monitoring (SHM) applications of a structure is based on the investigation of the incident, reflection, transmitted waves, and mode conversion of Lamb wave modes as they interact with damage. The interaction of Lamb waves with damage is a complex phenomenon. Existing discontinuity in the structure (e.g., a stiffener ...

Non-Contact 3D-Vision System for Rail Neutral Temperature Measurements

technology@sc.edu — Wed, 02 May 2018 13:21:39 GMT

Reference #: 01303The University of South Carolina is offering licensing opportunities for Non-Contact 3D-Vision System for Rail Neutral Temperature Measurements Background:Continuous Welded Rail (CWR) has become the standard in modern railway track construction around the world because it alleviates the well-documented disadvantages of rail joints in a track. CWR practice results in very long segments of continuous rail in the track that will develop significant thermal elongation. To avoid the use of impractical large thermal expansion joints, while limiting the expected larger thermal ...

Graphene Field Effect Transistors for Detection of Potassium Ions

technology@sc.edu — Fri, 06 Apr 2018 11:27:51 GMT

Reference #: 01290 The University of South Carolina is offering licensing opportunities for Graphene Field Effect Transistors for Detection of Potassium Ions Background:Sensors based on graphene are currently of strong technological interest in chemical, electrical, environmental, and biosensing applications since adsorbed molecules can readily affect its conductivity through charge transfer. Graphene, being essentially a surface, is extremely sensitive to changes in surface charge, or interaction with ionic adsorbates, presenting itself as an excellent material to develop ion sensitive ...

CCL24 as a Diagnostic and Therapeutic Target for Breast Cancer

technology@sc.edu — Fri, 06 Apr 2018 11:03:21 GMT

Reference #: 01238The University of South Carolina is offering licensing opportunities for using CCL24 as a diagnostic and therapeutic target for breast cancer. Background:Breast cancer is the most common cancer in women worldwide, and the second leading cause of cancer-related deaths among women in the United States. Of the many subtypes of breast cancer, triple negative breast cancer (TNBC) is the most lethal. There are multiple optional treatments for breast cancer, but disease recurrence remains a significant clinical challenge. Therefore, an unmet critical need is to identify ...

Dual-Polarization FBMC Wireless Communication System

technology@sc.edu — Wed, 04 Apr 2018 10:58:39 GMT

Reference #: 01316The University of South Carolina is offering licensing opportunities for a Dual-Polarization FBMC Wireless Communication System. Background:Orthogonal frequency-division multiplexing (OFDM) with cyclic prefix (CP) is today’s most widely-used multicarrier communication system due to its simplicity and robustness against frequency-selective channels. However, it loses spectral efficiency in highly-dispersive channels where a large portion of each OFDM symbol should be added as CP. Additionally, the OFDM power spectrum is not compact, and therefore requires windowing ...

Selective Inhibition of the Polo-Like Kinase 1 PBD for Cancer Therapy

technology@sc.edu — Fri, 30 Mar 2018 09:53:11 GMT

Reference #1307: Selective Inhibition of the Polo-Like Kinase 1 PBD for Cancer TherapyThe University of South Carolina is offering licensing opportunities for the Selective Inhibition of the Polo-Like Kinase 1 PBD for Cancer Therapy. Background:Polo-like kinase 1 (PLK1) has been shown to be over-expressed in a number of tumors. Its expression has been demonstrated to be adversely related to prognosis, thus making it a good therapeutic target. PLK1 is comprised of two structural domains: the kinase domain, containing the ATP binding site; and the protein substrate recognition polo-bo...

Cell Membrane Coated Nanoparticle for Brain Targeted Drug Delivery

technology@sc.edu — Fri, 30 Mar 2018 09:01:24 GMT

Reference #: 01315 The University of South Carolina is offering licensing opportunities for a Cell Membrane Coated Nanoparticle for Brain Targeted Drug Delivery. Background:Due to the existence of blood brain barrier (BBB), most of the small molecules for the treatment of central neural systems (CNS) diseases cannot cross the BBB. Development of efficient delivery systems for CNS drugs is urgently needed. Invention Description:The invention describes the preparation of a brain targeted nanoparticle and its application. The cancer cell membrane coated nanoparticle can effectively...

Highly Active Decomposition Catalyst for Low Carbon Hydrocarbon Production from Sulfur Containing Fuel

technology@sc.edu — Fri, 02 Mar 2018 10:38:44 GMT

Reference #: 00916 The University of South Carolina is offering licensing opportunities for this technology. Potential Applications: The basic application of the disclosed catalytic materials is targeted towards enabling portable fuel cells running on non-desulfurised jet fuel, in particular strategic military fuel (JP-8). Advantages and Benefits: Useful for the conversion of sulphur containing, high-C hydrocarbon fuel The conversion efficiency can be up to 23%, calculated on a mass basis. However it is envisioned that higher conversion efficiencies may be realized through optimizat...

Selectively Doped III-nitride High Electron Mobility Transistor

technology@sc.edu — Fri, 16 Feb 2018 13:27:12 GMT

Reference #: 00934 Background:University of South Carolina (USC) has pioneered the development of AlInGaN based insulating gate heterojunction field-effect-transistors. This includes AlGaN (barrier)/GaN (channel), AlGaN (barrier)/InGaN (channel) and AlInGaN (lattice matched barrier)/GaN (channel) devices. In addition, the University was the first to report on AlGaN-GaN and AlGaN-GaN-InGaN (back barrier) double heterojunction-field-effect-transistors (DHFETs). The research team at USC also fabricated E-mode HFETs with AlGaN-GaN HFETs using the conventional fluorine based gate r...

Systems and Methods for Liquid Fuel Desulfurization

technology@sc.edu — Fri, 16 Feb 2018 12:03:50 GMT

Reference #: 00946The University of South Carolina is offering licensing opportunities for Systems and Methods for Liquid Fuel Desulfurizationr Background:For fuel cell power generators employed in military field deployment, the use of logistic fuels (such as diesel, JP-5, JP-8, etc.) as the primary energy source is highly desired due to the high energy densities, economics, and wide availability of these fuels. However, these fuels typically contain high concentrations of sulfur compounds (up to 3000 ppm) and, if not removed, they can cause severe poisoning and deactivation to solid oxid...

Method of Growing High Quality, Thick SiC Epitaxial Films at High Growth Rates in a Hotwall CVD Reactor

technology@sc.edu — Fri, 16 Feb 2018 10:13:06 GMT

Reference #: 00948The University of South Carolina is offering licensing opportunities for Method of Growing High Quality, Thick SiC Epitaxial Films at High Growth Rates in a Hotwall CVD Reactor Background:One of the greatest challenges of growing SiC epitaxial films by high temperature chemical vapor deposition (CVD) is to restrict the gas phase nucleation or cluster formation or aerosol formation of silicon during growth. These particles adversely influence the growth by reducing the growth rate due to precursor losses, as well as degrading the crystal quality. A continuing need exists ...

Methods and Compositions for Inactivating Allergens and Allergen-Producing Organisms

technology@sc.edu — Fri, 02 Feb 2018 09:05:58 GMT

Reference #: 00690The University of South Carolina is offering licensing opportunities for this technologyPotential Applications:This technology has the potential to be used on a full-scale industrial level for purposes such as home carpet cleaning.Advantages and Benefits:With the combination of killing and removing dust mites and dust mite feces, indoor allergen levels will be significantly lowered compared to the usual deep vacuum cleaning method. More powerful, but still non-toxic, alternative to traditionally ineffective vacuuming Leaves no soluble solvent residuals Invention Description:A...

Removal of Bacterial Endotoxins

technology@sc.edu — Fri, 02 Feb 2018 09:02:39 GMT

Reference #: 00803Background:Bacterial endotoxins are residues from gram negative bacteria that can cause serious health problems if introduced into the blood stream. Therefore, bacterial endotoxins are a serious concern for companies in the reusable medical device field. Invention Description:The invention consists of a cleaning method for the complete removal of endotoxins from biomaterials and metallic substrates.Potential Applications:Hospitals, Clinics, Out-patient surgery centers, and Any company that requires endotoxin removal from reusable medical devices Small ...

Dually Electrically Tunable 3-D Compact RF Phase Shifter

technology@sc.edu — Thu, 25 Jan 2018 06:47:28 GMT

Reference #01302 The University of South Carolina is offering licensing opportunities for a Dually Electrically Tunable 3-D Compact RF Phase Shifter Background:The wireless communication market has been growing faster and faster in recent years, and the demand for supporting multiband and standards is ever-increasing. To achieve multifunctional and frequency-agile systems for modern and next generation wireless applications, compact tunable devices are pivotal. Invention Description:The invention is an electrically tunable radio frequency phase shifter with a compact 3-D struct...

Machine Learning to Identify Locations of Brain Injury

technology@sc.edu — Fri, 19 Jan 2018 12:30:08 GMT

Reference #: 01291The University of South Carolina is offering licensing opportunities for Using Biomarkers to Aid Stroke Treatment Background:Many individuals experience impairments following a brain injury. Brain scans (MRI, CT, fMRI) can help provide a prognosis for recovery, guide treatment, and help determine the ideal location for brain stimulation. Clinicians who apply transcranial stimulation cannot do so without first seeing where in the brain a patient has damage. This is a major problem, as the tools used for imaging the lesion location (MRI or CT) are very expensive, and are t...

Structurally Tunable Highly Active Metal Oxides for Tri-Reforming of Methane

technology@sc.edu — Fri, 19 Jan 2018 10:47:46 GMT

Reference #: 01304The University of South Carolina is offering licensing opportunities for Structurally Tunable Highly Active Metal Oxides for Tri-Reforming of Methane Background:Catalytic tri-reforming is a unique process that can be used to utilize CO2 emissions directly from a combustion source, such as a coal or natural gas power plant, using natural gas as the primary reactant. Currently, one tri-reforming plant is operated by Korea Gas Corporation to produce dimethyl ether (DME) in South Korea. The plant can produce 10,000 tons of DME per day using pellets of Ni/Ce-ZrO2/Al2O3 cataly...

Manufacturable Nickle-Graphene Interface for Highly Efficient and Durable Condensers

technology@sc.edu — Fri, 12 Jan 2018 12:25:11 GMT

Reference #:01272The University of South Carolina is offering licensing opportunities for an efficient and cost effective Nickel-Graphene surface to realize dropwise condensation. Background:Condensers are widely used in many applications, including air conditioners for automotive and building purposes, cooling units in industrial process, and condensing turbine exhaust steam into water. These play a crucial role in determining manufacturing and running costs of modern industrial processes. For example, in thermal power plants, condensers have been identified as the largest single energy ...

MicroRNA-30 in Therapy/Prevention of Inflammation, Obesity, and Metabolic Syndrome

technology@sc.edu — Fri, 27 Oct 2017 12:22:02 GMT

Reference #1298 The University of South Carolina is offering licensing opportunities for the use of MicroRNA-30 in Therapy/Prevention of Inflammation, Obesity, and Metabolic Syndrome. Background:Obesity is a global health issue that promotes risk for cardiometabolic diseases and some cancers. During obesity, adipose tissue macrophages (ATM) drive chronic low-grade inflammation that promotes metabolic dysfunction. Invention Description:Therapeutic strategies for obesity and related disorders have been challenging to develop. MicroRNAs are short non-coding RNAs that can inhibit g...

Graphene-Ceramic Composite for Hydrogen Separation Membranes

technology@sc.edu — Fri, 27 Oct 2017 12:13:28 GMT

Reference #01277 The University of South Carolina is offering licensing opportunities for graphene-ceramic composites used for hydrogen separation membranes. Background:Hydrogen is produced in large quantities worldwide for applications in the fertilizer and petroleum industries. Metal-ceramic cermet composites such as nickel-ceramics have been widely used for high temperature hydrogen permeation membranes. These membranes are used for applications in hydrogen production and hydrogen separation. While the ceramic phase is the ionic conducting phase, nickel is the main electronic cond...

Alumina Substrate Supported Microtubular Solid Oxide Cells

technology@sc.edu — Fri, 27 Oct 2017 11:41:29 GMT

Reference #1275 The University of South Carolina is offering licensing opportunities for a novel microtubular solid oxide fuel cell technology. Background:Solid oxide fuel cells (SOFC) are energy conversion devices which convert the chemical energy of fuels and oxidants directly into electrical energy in an environmentally benign and highly efficient manner. The basic structure of an SOFC is a tri-layer assembly, in which the dense electrolyte is sandwiched by porous anode and cathode electrodes on either side. Since the resistance of electrolyte is proportional to its thickness, thi...

Engineered Matrix for Enriching Malignant Cancer Stem Cells

technology@sc.edu — Fri, 06 Oct 2017 12:42:05 GMT

Reference #: 01067 The University of South Carolina is offering licensing opportunities for a novel system for testing cancer drugs. Invention Description: Cancer recurrence or relapse is related to a very small population of highly-malignant and metastasizing cancer stem cells that have the ability initiate, propagate, and maintain the cancer tissue. This invention is a material composition that allows the growth and survival of cancer initiating/stem cells, or those cancer cells that are resistant to therapy. When any cancer cell line is embedded in the material composition of this invention...

Flexible Fuel Converter: Transportation Fuels to LPG

technology@sc.edu — Fri, 06 Oct 2017 07:59:36 GMT

Reference #: 01040The University of South Carolina is offering licensing opportunities for this novel, low-maintenance system of converting fuel to liquefied petroleum gas.Invention Description:This invention allows a user to transform a variety of transportation fuels into liquefied petroleum gas (LPG). The converter is designed to operate in remote locations; it requires only fuel and air, and does not require desulfurization, water, purified gas inlets, or additional reactants. As such, the fuel converter provides fuel diversification at the point of use while leveraging current distr...

Welding of Thermoplastic Composites Using Vacuum-Bagging, Air-Cooling, and Induction

technology@sc.edu — Fri, 29 Sep 2017 09:34:30 GMT

Reference #: 01292The University of South Carolina is offering licensing opportunities for the welding of thermoplastic composites using vacuum-bagging, air-cooling and induction. Background:Welding of thermoplastic composites needs both pressure and temperature. This pressure can be generated using compaction rollers or mechanical pressure from a tool block or a pressurized tube/bag. Induction welding of composite parts is currently done with very expensive and heavy tools. High non-recurring costs hamper the application of induction welding in the composite structure industry. Inve...

(rgs-CaM) - A Method to Manipulate Gene Silencing in Plants

technology@sc.edu — Fri, 29 Sep 2017 07:24:57 GMT

Reference #: 00212The University of South Carolina is offering licensing opportunities for this technologyInvention Description:The subject invention defines the rgs-CaM sequence and resulting gene product sequence. rgs-CaM inhibits cosuppression thereby allowing an increase in expression of target genes. It is also possible however to use rgs-CaM to enhance the suppression pathway and stabilize the silenced version which is beneficial to prevent the production of undesirable gene products. Like prior inventions by the same inventor (ID#126 and 211), this technique enab...

Predictive Control Algorithm for Power Hardware in the Loop Systems

technology@sc.edu — Fri, 15 Sep 2017 12:40:09 GMT

Reference #: 00635 The University of South Carolina is offering licensing opportunities for a Predictive Control Algorithm for Power Hardware in the Loop Systems. Background:Hardware-In-the-Loop (HIL) is increasingly recognized as an effective approach for simplifying the process of prototyping and testing of complex systems. In the HIL approach, real hardware components being tested interact with an operational virtual environment that combines a real-time simulation engine with an electronic interface for analog and digital signals. Subsystems signally coupled with the hardware are...

Therapeutic Wound Healing Composition of Myricetin-3-O-rhamnoside and Chlorogenic Acid

technology@sc.edu — Fri, 15 Sep 2017 11:53:47 GMT

Reference #: 01295 The University of South Carolina is offering licensing opportunities for a therapeutic wound healing composition of myricetin-3-o-rhamnoside and chlorogenic acid. Background:The regeneration of healthy and functional skin remains a huge challenge due to its multilayered structure and the presence of different cell types organized within the extracellular matrix. Despite recent advances in wound care products, traditional therapies based on natural compounds, such as plant extracts and natural active components offer viable alternatives, enhancing access to healthca...

Detection of Succination as a Measure of Fumarate Ester Efficacy

technology@sc.edu — Fri, 25 Aug 2017 06:55:26 GMT

Reference #: 01221The University of South Carolina is offering licensing opportunities for a technology that facilitates the measurement of protein succination levels in body fluids/tissues. Background:Dimethylfumarate/Monomethylfumarate-containing drug formulations are increasingly prescribed in the US for the treatment of relapsing remitting multiple sclerosis (M.S). However, despite their clinical efficacy they are associated with side effects and an increased risk of developing progressive multifocal leukoencephalopathy (PML), a deadly brain infection. To date, the only way to monitor...

Macrophage Enabled 3D Enrichment of Cancer Stem Cells

technology@sc.edu — Tue, 15 Aug 2017 10:13:44 GMT

Reference #: 01261The University of South Carolina is offering licensing opportunities for using a 3D cell culture system can be used to test cancer drugs against the most aggressive and malignant cancer cell populations. Background:A major contributing factor to mortality in cancer patients is relapse (after surgery or therapy) and developing resistance to therapy. For example, breast cancer recurrence affects 30% of the patients and leads to $10-22K increase in cost over 10 years. Cancer recurrence is related to the existence of a very small population of cancer stem cells (CSCs) in the...

Drug Uptake by Cancer Stem Cells via Conjugation Silica Nanoparticles

technology@sc.edu — Tue, 15 Aug 2017 10:07:08 GMT

Reference #1267:The University of South Carolina is offering licensing opportunities for a novel two part drug therapy for cancer cells with conjugation silica nanoparticles. Background:More than 12 million new cancer cases are diagnosed worldwide each year, with an estimated 8 million deaths occurring in the same year. A major contributing factor to mortality in cancer patients is relapse (after surgery or therapy) and developing resistance to therapy. A small population of highly malignant cancer stem cells (CSCs) have the ability to initiate, propagate, and maintain the cancer tissue. ...

High-Strength Reduced-Elastic Modulus Concrete for Railroad Tie Applications

technology@sc.edu — Fri, 11 Aug 2017 11:30:48 GMT

Reference #: 01191 The University of South Carolina is offering licensing opportunities for fabricate pre-stressed concrete rail ties that are more flexible and cost-effective than existing rail ties. Invention Description:The subject invention is a High-Strength Reduced-Modulus High Performance Concrete (HSRM-HPC) used to fabricate pre-stressed concrete rail ties. The HSRM-HPC is much more flexible than the concrete material currently used in the fabrication of ties. The use of the more flexible HSRM HPC in concrete ties prevents premature cracking extending, thus, the life span of the t...

Hydrogen Sulfide (H2S) Releasing Donor Compound for Dermal Wound Regeneration

technology@sc.edu — Fri, 04 Aug 2017 10:21:26 GMT

Reference #: 01289 The University of South Carolina is offering licensing opportunities for an H2S -releasing donor compound for dermal wound regeneration. Background:Hydrogen sulfide (H2S), together with nitric oxide and carbon monoxide, has been recognized as an important gasotransmitter. It plays an essential physiological role in regulating cyto-protective signal processes, and H2S-based therapy is considered to be the next generation of promising therapeutic strategy for many biomedical applications, such as the treatment of cardiovascular disease. The physiological function of ...

miR-489 as a New Biomarker in Breast Cancer

technology@sc.edu — Fri, 04 Aug 2017 09:58:54 GMT

Reference #: 01158 The University of South Carolina is offering licensing opportunities for a specific micro RNA (miR-489) as a new diagnostic and prognostic biomarker in breast cancer. Background:Breast cancer is the most commonly diagnosed cancer, and has a high rate of mortality in women. Despite aggressive clinical treatment including surgical resection, radiation, and chemotherapy, tumor recurrence is essentially universal. Breast cancer is a heterogeneous disease with several subtypes (Basal, HER2, Luminal A, Luminal B, and Normal-like subtypes) identified by unique molecular s...

Sensitivity Markers and Uses for CDK7 Inhibitors

technology@sc.edu — Fri, 28 Jul 2017 11:57:09 GMT

Reference #: 01288The University of South Carolina is offering licensing opportunities for sensitivity markers and uses for CDK7 inhibitors in the selection of cancer patients who are most likely to benefit from CDK7-targeting drugs. Background:In recent years, the advent of targeted therapies for estrogen receptor (ER) positive and HER2 positive breast cancer has significantly improved the outcome for breast cancer patients. However, lack of response and high rates of relapse following treatment are significant clinical issues in the management of breast cancer. In addition, there is a d...

Energy Scavenging from Broadband Ambient Vibration Using Sonic Crystal

technology@sc.edu — Fri, 28 Jul 2017 08:44:07 GMT

Reference #1281:The University of South Carolina is offering licensing opportunities for a Smart Sonic Crystal used for broadband ambient energy scavenging. Background:Almost all individuals in the USA will be using some form of electronic gadget (laptops, tablets, cell phones, e-reader, etc.) by 2020. That will increase the energy demand by a factor of ~2 for charging these electronic devices. Currently, there are two main types of energy harvesters on the market: Cantilever Beam type energy harvesters, and Plate type energy harvesters. The primary shortcoming of such harvesters are that...

Photovoltaic Cell Energy Harvesting from Fluorescent Lights

technology@sc.edu — Fri, 21 Jul 2017 09:17:03 GMT

Reference #: 01260 The University of South Carolina is offering licensing opportunities for a system that harnesses ambient excess energy from fluorescent lights and uses it to power a wireless sensor node that connects to other devices. Background:In today’s modern world, a significant amount of energy is being wasted or not used efficiently. This invention focuses on the energy that is being output by the florescent lights that are used in most buildings. Invention Description:The invention uses a solar panel to harness the wasted energy coming from florescent lights. The ene...

Acoustic Black Hole ABH Sensor

technology@sc.edu — Fri, 21 Jul 2017 08:26:36 GMT

Reference #: 01190The University of South Carolina is offering licensing opportunities for a highly sensitive, acousto-ultrasonic sensor achieved through the application of acoustic black hole concepts. Invention Description:The subject invention is an acousto-ultrasonic sensor with a high-sensitivity response enhancement achieved through the application of acoustic black hole concepts. The resulting sensor sensitivity is expected to be orders of magnitude larger than existing acoustic emission and ultrasonic sensors. The sensor output signal can be presented as a photonic (fiber optic) s...

On-Demand Sweating-Boosted Air Cooled Heat-Pipe Condensers

technology@sc.edu — Fri, 21 Jul 2017 07:34:13 GMT

Reference #: 01198The University of South Carolina is offering licensing opportunities for On-Demand Sweating-Boosted Air Cooled Heat-Pipe Condensers Background:AS part of initiates for the development of a green economy, the U.S. federal government requires 2% annual reduction of water use for industrial, domestic, commercial, and agricultural applications, which imposes challenges to power industries that accounted for 41% of total freshwater withdrawals and consumed approximately 143,000 million gallons freshwater per day in 2005. Air cooled condensers (ACC) can drastically reduce wate...

A Self-forming Membrane for High-flux and Selective Electrochemistry-based CO2 Capture

technology@sc.edu — Tue, 18 Jul 2017 11:30:08 GMT

Reference #: 01268The University of South Carolina is offering licensing opportunities for a self-forming membrane for high-flux and selective electrochemistry-based CO2 capture. Background:Coal-fired and gas-fired power plants are the primary power suppliers of the modern society, as well as the primary CO2 emitter. The current CO2 capture technologies are too expensive and cumbersome to implement into existing power plants. The new membranes have potential to replace the existing technology for power plant CO2 capture with high efficiency and low cost. Given the performance level demons...

Preparation of Metallocene-Containing Cationic Polymers for Anion Exchange Application

technology@sc.edu — Fri, 07 Jul 2017 10:59:04 GMT

Reference #1283:The University of South Carolina is offering licensing opportunities for the preparation of metallocene-containing cationic polymers for anion exchange applications. Background:Anion exchange membranes (AEMs) have attracted more interest in recent decades because anion exchange membrane fuel cells (AEMFCs) use less expensive metallic catalysts and provide higher energy efficiency compared to proton exchange membrane fuel cells (PEMFCs). However, most available anion exchange materials suffer from either poor mechanical property or long term alkaline stability. Our design p...

Voltage Tunable Solar-Blind UV Detector Using EG/SiC Bipolar Photo-Transistor

technology@sc.edu — Fri, 07 Jul 2017 10:42:52 GMT

Reference #1285:The University of South Carolina is offering licensing opportunities for a Voltage tunable solar-blind unltraviolet detector an Epitaxial Graphene/SiC bipolar photo-transistor Background:This invention allows the replacement of the metal electrodes used in conventional SiC UV detectors with a highly transparent graphene layer, leading to better output responsivity under low UV signal conditions. This invention demonstrates some potential applications of this technology in electronic and optoelectronic devices for UV monitoring, optical communications, defense, gas sensors,...

Surface Grafted HIPE Foams for Chemical Separations

technology@sc.edu — Mon, 12 Jun 2017 13:30:58 GMT

Reference #: 01232The University of South Carolina is offering licensing opportunities for using a new magnetic nanoparticle fabrication technology. Background:Magnetic nanoparticles (MNPs) are a class of nanoparticle that possess unique chemical, structural, electrical, and magnetic properties. They consist of three functional parts: a magnetic core, a surface coating, and a functionalized outer coating. The super-paramagnetic core is the most consequential part of this nanoparticle since it allows for the magnetic manipulation of the particle in the presence of an external magnetic fiel...

Use of a Newly Discovered Pimarane Diterpenoid for Wound Healing

technology@sc.edu — Mon, 12 Jun 2017 09:53:58 GMT

Reference #1282:The University of South Carolina is offering licensing opportunities for a newly discovered pimarane diterpenoid compound for use in wound healing. Background:The regeneration of healthy and functional skin remains a huge challenge due to its multilayered structure and the presence of different cell types organized within the extracellular matrix. Despite recent advances in wound care products, traditional therapies based on natural compounds, such as plant extracts and natural active components offer viable alternatives. These compounds have the ability to enhance access ...

Use of a Newly Discovered Pimarane Diterpenoid for Cancer Treatment

technology@sc.edu — Mon, 12 Jun 2017 09:20:16 GMT

Reference #1279:The University of South Carolina is offering licensing opportunities for a newly discovered Pimarane Diterpenoid for use in cancer treatment. Background:Cancers and other neoplastic diseases are the cause of poor health and early death in many patients throughout the world. The treatment of these diseases has traditionally been accomplished through one of, or a combination of, the following techniques: chemotherapy, surgery, radiotherapy, and hormone therapy. However, the differences in genetic expression, drug sensitivity, cell morphology, and metastatic targets across th...

Use of a Newly Discovered Sesterterpenoid for Cancer Treatment

technology@sc.edu — Mon, 12 Jun 2017 09:19:22 GMT

Reference #1280:The University of South Carolina is offering licensing opportunities for a newly discovered sesterterpenoid for use in cancer treatment. Background:Cancers and other neoplastic diseases are the cause of poor health and early death in many patients throughout the world. The treatment of these diseases has traditionally been accomplished through one of, or a combination of, the following techniques: chemotherapy, surgery, radiotherapy, and hormone therapy. However, the differences in genetic expression, drug sensitivity, cell morphology, and metastatic targets across the doz...

Stethoscope With Extended Body Sounds Detection

technology@sc.edu — Wed, 07 Jun 2017 12:07:17 GMT

Reference #1276:The University of South Carolina is offering licensing opportunities for a novel stethoscope with an extended frequency range of bodily sound detection. Background:It has been reported that healthcare practitioners today are not very good at listening and identifying heart sounds with a stethoscope. This can cause problems in patient diagnosis as well as detection of the progression or regression of diseases. Invention Description:This invention is a small disk acoustic receiver that makes contact with the body in a similar way to a stethoscope. However, in addition t...

Polyamide/Nitrogen-Doped Graphene Oxide Quantum Dots (N-GOQD) Thin Film Nanocomposite Reverse Osmosis Membranes for High Flux Desalination

technology@sc.edu — Fri, 12 May 2017 08:59:07 GMT

Reference #: 01248 The University of South Carolina is offering licensing opportunities for novel additives for thin film nanocomposite polyamide membranes for use in reverse osmosis desalination. Background:Lack of clean fresh water is a prominent issue in the modern world. With such a large fraction of seawater available desalination is a viable option to gain usable water for daily needs as well as corporate and industrial processes. Reverse Osmosis is a widely applied desalination technique, with thin film nanocomposite (TFN) membranes considered to be the best in use. Polyamide ...

Laser Line Directional System for 3D-Anatomy Ultrasound Phantom Trainer

technology@sc.edu — Fri, 12 May 2017 08:51:12 GMT

Reference #: 01266 The University of South Carolina is offering licensing opportunities for a Laser Line Directional System for 3D-Anatomy Ultrasound Phantom Trainer. Background:The skill of performing ultrasound is becoming a standard in medical education and clinical practice across a wide range of disciplines such as anatomy and pathology and clinical practice from primary care to orthopedics and neurosurgery. Ultrasound is being used as a clinical tool by physicians, nurses, physician assistants, emergency medicine technicians, midwives, medics, and other healthcare providers. Po...

Passive Resonator

technology@sc.edu — Mon, 08 May 2017 13:06:37 GMT

Reference #: 01237 The University of South Carolina is offering licensing opportunities for using a device that modifies brainwave frequencies and establishes coherence between different cortical regions making the personalized treatment of individuals with mental disorders feasible. Background: It has been estimated that approximately one in four individuals in the general population meet diagnostic criteria for a mental disorder. Though pharmacological interventions have been employed in the past for psychiatric diagnosis and treatment of these disorders, their sometimes unacc...

Decellularization of Tissues Using Supercritical CO2

technology@sc.edu — Fri, 05 May 2017 07:41:30 GMT

Reference #: 01258 The University of South Carolina is offering licensing opportunities for using an efficient decellularization method to produce natural tissue scaffolds. Background:Decellularized tissues are utilized as scaffolds in numerous tissue engineering applications. These materials are often treated with aqueous detergents, which can require many hours, damage the microstructure, and/or leave behind cytotoxic residue. Supercritical carbon dioxide (CO2) offers faster, gentler treatment of these materials. Invention Description:The subject invention is a cleaning...

Detection of Smoking Gesture Using Smart Watches

technology@sc.edu — Mon, 24 Apr 2017 10:24:55 GMT

Reference #: 01208The University of South Carolina is offering licensing opportunities for a technology that automates the detection of smoking gesture using smart watches Background:Non-intrusive monitoring of smoking behavior has become the main bottleneck in understanding the social and psychological components of smoking. Invention Description:The subject invention is a smartwatch that can detect when a person is smoking. It allows for automatic and nonintrusive detection of smoking gesture to enable further study of smokers in their natural environments and allow for the initia...

Multi-Chamber Pellet Die System

technology@sc.edu — Mon, 24 Apr 2017 10:02:45 GMT

Reference #: 01201The University of South Carolina is offering licensing opportunities for using a multi-chamber pellet die system designed for improved manufacturing capability. Background:Currently, pellet dies are used to press KBr pellets for IR Spectroscopy and small biomaterial scaffolds used in tissue engineering applications. However, these pellet dies are not compatible with high-throughput applications, as these dies cannot produce more than one pellet at a time. Invention Description:The subject invention is a Multi-Chamber Pellet Die System that improves the manufacturing...

Supercritical CO2 Extraction of Residual Glutaraldehyde From Crosslinked Collagen

technology@sc.edu — Fri, 21 Apr 2017 13:11:16 GMT

Reference #: 01257The University of South Carolina is offering licensing opportunities for Supercritical CO2 Extraction of Residual Glutaraldehyde from Crosslinked Collagen. Background:Because of the scarcity of heterologous donor organs required for transplantation, interest in engineered tissues has spiked. Since the emergence of tissue engineering (TE) as a scientific field, collagen has been used as a biomaterial for tissue engineering scaffolds because of its excellent bio-inductive and degradable properties. Collagen is a protein found throughout the body of both humans and an...

Drug Conjugated Nanogels in Microcapsule for Delayed Sustained Protein Delivery

technology@sc.edu — Fri, 21 Apr 2017 11:13:20 GMT

Reference #: 01255The University of South Carolina is offering licensing opportunities for an innovative approach to synthesize a nanogels-in-microparticle delivery system with delayed and sustained release of protein or peptide-based biologiocally active agents. Background:In many medical applications, drugs, peptides, proteins, morphogens, cytokines, enzymes, or biologically active agents need to be released locally with a delay or within a specified time interval in situ in a tissue. Specifically in regenerative medicine, biologically active agents like morphogens need to be released i...

Identify Structural Defect Geometric Features from Acoustic Emission Waveforms

technology@sc.edu — Fri, 21 Apr 2017 07:52:51 GMT

Reference #: 01199The University of South Carolina is offering licensing opportunities for a technology that identifies structural defect geometric features from acoustic emission waveforms. Background:Acoustic emissions (AE) waves are generated by a sudden redistribution of stress in a material or structure. AE techniques have many industrial applications, such as assessing structural integrity, detecting flaws, testing for leaks, or monitoring weld quality, and is used extensively as a research tool. In this work, a system/method was developed for detecting acoustic emissions wave signa...

Flange Connectors for Double Tee Beams

technology@sc.edu — Fri, 21 Apr 2017 07:05:56 GMT

Reference #: 1172The University of South Carolina is offering licensing opportunities for a new durable and easily installed joint connection for double tees to be used in parking structure application. Invention Description:The subject invention is a new durable and easily installed joint connection for double tees for parking structure application. Advantages and Benefits:This technology uses an elastic shape memory alloys (SMA) connector that is unique and has the following key attributes:1. These materials are non-corroding and highly dura...

Amine-Enhanced Graphene Oxide (GO) Membranes for CO2 Separation

technology@sc.edu — Fri, 21 Apr 2017 06:36:36 GMT

Reference #: 01240The University of South Carolina is offering licensing opportunities for using a new advanced CO2 separation technology. Background:Amine absorption is the current benchmark technology for CO2 separation. However, this technology is energy intensive and costly. For example, when considering CO2 capture from flue gas in power plants, DOE/NETL systems analysis studies estimate that using a chemical absorption with an aqueous monoethanolamine system to capture 90% of the CO2 from flue gas will require an increase in the levelized cost of energy (LCOE) services by 75-85%. Th...

Composition for In Situ Zonal Regeneration of Articular Cartilage

technology@sc.edu — Fri, 21 Apr 2017 06:12:01 GMT

Reference #: 01259 The University of South Carolina is offering licensing opportunities for using therapies that mimic the regeneration of the zonal organization of articular cartilage. Background:Approximately 12% of all osteoarthritis (OA) cases are caused by post-traumatic osteoarthritis (PTOA). About 3.5 million individuals in US suffer from PTOA of the hip, knee, or ankle with a total cost of $3 billion to the health care system. PTOA can occur in any age from any acute physical trauma such as sports, vehicle accidents, falls, or military injury. PTOA results in some form of per...

Growth-Independent Inhibition of Aflatoxin Biosynthesis With Selected Silver Nanoparticles

technology@sc.edu — Thu, 20 Apr 2017 14:39:40 GMT

Reference #: 01253The University of South Carolina is offering licensing opportunities for using selected silver nanoparticles to inhibit aflatoxin biosynthesis. Background:Chronic low-level exposure of aflatoxins and other carcinogenic mycotoxins is a serious potential health threat to both plants and animals. Silver nanoparticles (Ag NPs) have emerged as a great candidate to address the challenge these toxins pose due to their antimicrobial properties and efficacy in controlling diverse and multi-drug resistant microbes. They are generally preferred to silver ions because of their low...

Basal Plane Dislocations Elimination and Conversion Below the Epilayer Interface

technology@sc.edu — Thu, 20 Apr 2017 14:37:43 GMT

Reference #: 01252The University of South Carolina is offering licensing opportunities for a novel approach for improving the quality of semiconductor materials (4H-SiC). Background:Power electronic semiconductor devices are critical components in next-generation energy-efficient power systems such as electric vehicles, smart grid power controls, and alternative energy grid-compatibility circuitry. Their power handling capabilities and ability to operate at high temperatures without active cooling enables transformative system-level improvements such as reduction in size, weight, and perf...

KeratATE Three-Dimensional Cell Culture System

technology@sc.edu — Thu, 20 Apr 2017 14:34:31 GMT

Reference #: 01250The University of South Carolina is offering licensing opportunities for access to knowledge about a 3D biomimetic/biologic, trypsin-degradable cell culture system. Background:Mammalian cells are traditionally cultured and expanded on 2D cell culture flasks. However, the 2D culture flasks do not mimic the cell environment in vivo, leading to significant morphological changes in the cells. This renders the expanded cells unusable for clinical applications. Invention Description:This invention describes a 3D biomimetic/biologic, trypsin-degradable cell culture system...

Transfer-free Synthesis of High Quality Molybdenum Disulfide Thin Films

technology@sc.edu — Thu, 20 Apr 2017 14:33:03 GMT

Reference #: 01249The University of South Carolina is offering licensing opportunities for using a production process for a thin film material, which can lead to a very viable manufacturing process for highly efficient transistors and other electronic devices. Background:Since the discovery of graphene, there has been an increase in researching the scalability of two-dimensional (2D) materials down to atomic dimensions. Among the analogs of graphene, transition metal dichalcogenides (TMDs) are attractive due to their exceptional electronic and optoelectronic properties. MoS2, a TMD, has s...

Left-Right Gene Expression Signature for Triple Negative Breast Cancer

technology@sc.edu — Thu, 20 Apr 2017 14:03:04 GMT

Reference #: 01251The University of South Carolina is offering licensing opportunities for using left-right signatures that can distinguish between non-metastatic and metastatic triple negative breast tumors. Background:The three most common types of receptors known to fuel breast cancer growth are estrogen, progesterone, and the HER-2. A patient is said to have been diagnosed of triple negative breast cancer when these factors are absent. Approximately 15-20% of all breast cancer patients have tumors that are classified as triple negative breast cancers. The distinction between this kind...

Using Mosquito Proteins to Create Dengue Virus Transmission-blocking Vaccines

technology@sc.edu — Fri, 14 Apr 2017 09:52:11 GMT

Reference #: 01165The University of South Carolina is offering licensing opportunities for a novel method of using mosquito proteins to control the spread of dengue virus. This method breaks the host-vector infection cycle that is responsible for continued viral transmission and human disease. Invention Description:The subject invention blocks proteins required for dengue infection using vaccination-induced antibodies, which can be produced in susceptible mammals (humans) by the injection of the mosquito protein and/or it's peptides and/or DNA sequence (DNA vaccination). When a mosquito b...

Tuning of Persistent Micelles

technology@sc.edu — Thu, 06 Apr 2017 07:29:33 GMT

Reference #: 01243 The University of South Carolina is offering licensing opportunities for tunable persistent micelles Background: This technology can be useful for many applications in which the size of micelles largely determines their performance. Managing the conditions that prevent micelles from changing their size therefore have many advantages. However, the adjustment of micelles under such conditions is very difficult. Invention Description: The subject invention is a method that can be used to quickly adjust the size of micelles and then return them to a per...

New Tetragen Scintillators

technology@sc.edu — Tue, 07 Mar 2017 11:45:04 GMT

Reference #: 01218The University of South Carolina is offering licensing opportunities for a new class of scintillator materials for LED light bulb coatings, radiology and radiation detection applications. Background:Scintillators are materials which when struck or excited by an incoming particle (ionizing radiation) absorb its energy and exhibit luminescence. Hence, the scintillation process involves the conversion of high-energy photons into visible light via interaction with a scintillator. Scintillators possess properties like density, refractive index, wave length, decay time etc. T...

New Deployment Method for Use of Nanotechnology for Oil Remediation

technology@sc.edu — Fri, 10 Feb 2017 06:48:43 GMT

Reference #: 01235 The University of South Carolina is offering licensing opportunities for the use of a new nanotechnology-related deployment method for oil remediation. Background: Oil spills are environmental disasters that have the potential to cause catastrophic damage to aquatic ecosystems and negatively impact humans, plants, and wildlife. These spills, usually containing crude oil and its water-accommodated fractions (WAF), can be highly toxic. It is required by law in various jurisdictions that spills prepared for, and a response plan is expected to be deployed in the ...

Direct Synthesis Of Hydrocarbons From Co-Electrolysis In Micro Tubular Reactor

technology@sc.edu — Mon, 06 Feb 2017 13:07:52 GMT

Reference #: 01193 The University of South Carolina is offering licensing opportunities for a technology that directly synthesizes hydrocarbons from co-electrolysis in a micro tubular reactor. Background: The widespread use of fossil fuel has led to the extensive emission of greenhouse gas (CO2) and a series of environmental problems. Therefore, significant attention has been paid to the reduction of atmospheric CO2 concentration and re-utilization of CO2. Solid oxide electrolysis cells (SOECs) electrochemically convert CO2 and H2O to syngas (a mixture of H2 and CO), which can b...

Photocrosslinkable Keratin-based Hydrogel for Cell Encapsulation

technology@sc.edu — Mon, 06 Feb 2017 09:21:19 GMT

Reference #: 01216 The University of South Carolina is offering licensing opportunities for the preparation of a modified keratin from poultry feathers for improving material properties. Background: Hydrogels are used extensively as matrices for delivery and immobilization of stem cells to the site of defect in soft tissue regeneration. They resemble the extracellular matrix (ECM) of soft tissues due to their crosslinked network of macromolecular chains which absorb large amounts of water without dissolving. Collagen and denatured gelatin (and their composites) are widely used ...

Wireless Assessment of Damage During Manufacturing

technology@sc.edu — Mon, 06 Feb 2017 08:49:03 GMT

Reference #: 01184 The University of South Carolina is offering licensing opportunities for a non-intrusive (wireless) method for the detection and classification of damage that may occur during the manufacturing process of composite or metallic structures, with a focus on aircraft. Invention Description: The invention is an approach and associated algorithms for the detection and classification of damage that may occur during manufacturing of aircraft. Such damage includes but is not limited to impact due to tool drops and/or rolling impacts, delaminations, changes in the acous...

Rapid and Robust Porous Polymers Enabled by New Etch Chemistry

technology@sc.edu — Fri, 27 Jan 2017 11:53:46 GMT

Reference #: 01215The University of South Carolina is offering licensing opportunities for self-assembling block copolymers to yield organized materials with small feature sizes. Invention Description: The subject invention is an aqueous etch chemistry that was developed for the improved production of porous polymers by the etching of a sacrificial polylactide block from self-assembled block copolymers. Background: Block copolymers self-assemble to yield organized materials with small feature sizes. The selective removal of one polymer block results in the production of polymers wit...

Growth Of Human Cancers In Peromyscus

technology@sc.edu — Fri, 27 Jan 2017 11:41:47 GMT

Reference #: 01211 The University of South Carolina is offering licensing opportunities for an experimental methodology that allows growth of transplantable human tumors on appropriate subjects and can be tested with results that mimic drug tests in naturally existing populations Invention Description: The subject invention is a protocol that allows growth of human cancers (xenografts) in animals of the genus Peromyscus. The protocol results in the immunosuppression in Peromyscus and hence the growth of transplantable human tumors that can be effectively drug tested. Human cancers th...

Preparation of Maleate and Maleimide Monomers and Polymers from Triglycerides

technology@sc.edu — Wed, 25 Jan 2017 09:22:23 GMT

Reference #: 01225The University of South Carolina is offering licensing opportunities for the preparation of Maleate and Maleimide Monomers and Polymers from Triglycerides Invention Description: The subject invention is a synthetic approach to the preparation of MALEATE and MALEIMIDE monomers and their polymers from plant oils. This approach is simple, low cost and scalable. These monomers and materials can replace petroleum-based chemicals, fuels and materials. Background: Most polymers derived from triglycerides are thermosetting and non-processable. This invention solves th...

Tunable Nanomaterials by Templating from Kinetically-trapped Polymer Micelles

technology@sc.edu — Wed, 25 Jan 2017 08:57:49 GMT

Reference #: 01205The University of South Carolina is offering licensing opportunities for use of a method of enabling adjustments to nanostructures where their architectural features can be changed independently, at will. Invention Description:The subject invention is a method/procedure that enables adjustments to nanostructures (produced by self-assembly) where the architectural features can be changed independently, at will. Background: Porous and nanoscale architectures of inorganic materials have become crucial for a range of energy and catalysis applications, where the ability ...

Method to Fabricate Micro-channel Array Structured Micro-tubular Solid Oxide Cells

technology@sc.edu — Mon, 12 Dec 2016 13:06:54 GMT

Reference #: 01162 The University of South Carolina is offering licensing opportunities for microchannel array structured microtubular solid oxide cells with improved power density and efficiency. Background: Typical microtubular anode-substrates prepared in open literature have the feature of multiple-layered microstructures, where a sponge-like layer is sandwiched by two thick finger-like layers on either side, and the inner and outer surfaces of the micro-tube are covered by thin but relatively dense skin layers. The thick finger-like layers are embedded with large continuo...

Bypass Switch for High Voltage DC Systems

technology@sc.edu — Wed, 14 Sep 2016 09:22:58 GMT

Reference #: 01220 The University of South Carolina is offering licensing opportunities for a bypass switch for high voltage DC systems. Background: In many DC applications, switching converter modules are series-connected to achieve higher voltage operation. Typical examples are multi‐level converters. If a converter cell fails, it is desirable to be able to bypass it so that the rest of the converter can still operate, possibly at a reduced power level. Desirable features of a bypass switch are fast closing speed, high current capability, low conduction loss, and long lifetim...

Multi-sealant System for Improved Shingle Resistance to Separation

technology@sc.edu — Tue, 13 Sep 2016 14:04:09 GMT

Reference #: 01210 The University of South Carolina is offering licensing opportunities for a Multi-sealant System for Improved Shingle Resistance to Separation Background: It has been documented that existing asphalt roof shingles may delaminate at significantly lower wind speeds than those for which they are rated, with major consequences on safety and repair costs. Amongst several, one practical approach to improving the situation would be to add a second self-sealing strip. It is found that standard three tab shingles can be designed to optimize the position of two sealant ...

Drug Releasing Polymer Implants for the Treatment of Metabolic Disorders

technology@sc.edu — Tue, 13 Sep 2016 13:53:18 GMT

Reference #: 01219 The University of South Carolina is offering licensing opportunities for Drug Releasing Polymer Implants for the treatment of Metabolic Disorders Background: Obesity is a major risk factor for heart disease, stroke, type-2 diabetes, and certain types of cancer. The current therapies for obesity are lifestyle changes including eating fewer calories and increasing physical activity, with medications and highly invasive weight-loss surgery being options if lifestyle changes are ineffective. However, despite implementation of these therapies there has been no si...

Accelerated Test Protocols for SOFC Cathodes

technology@sc.edu — Tue, 13 Sep 2016 13:35:38 GMT

Reference #: 01161 The University of South Carolina is offering licensing opportunities an accelerated Test Protocols for SOFC Cathodes Background: A Solid Oxide Fuel Cell (SOFC) can operate directly on natural gas, bio gas, and propane. It can also be operated on hydrogen, coal bed methane and similar light hydrocarbons. The fuel streams and oxidant do not mix or burn. SOFC produces electricity electrochemically by converting the chemical energy of the fuel directly into electrical energy thus increasing the efficiency of power production. Electrical efficiencies close to 70%...

Methodology/System for Reforming Liquid Fuel to Tailor Engine Combustion-Emissions

technology@sc.edu — Tue, 13 Sep 2016 13:29:36 GMT

Reference #: 01156 The University of South Carolina is offering licensing opportunities for a methodology/system for reforming liquid fuel to tailor engine combustion-emissions. Background: In compression ignited systems, the auto-ignition timing is inherently related to the chemical properties of the fuel charge and can also be controlled by the stratification of the charge. Controlling auto-ignition and burn rate for liquid- fueled reactivity controlled compression ignition (RCCI) cycles by varying fuel properties on the fly would require complex dual storage ...

BK Channels as Non-Genomic Estrogen Targets for Overactive Bladder

technology@sc.edu — Tue, 28 Jun 2016 08:46:59 GMT

Reference #: 01195 The University of South Carolina is offering licensing opportunities for a novel approach to treat overactive bladder and other urological diseases by positive modulation of BK channels with estrogen (17β-estradiol).Invention Description: The invention targets the large conductance voltage- and calcium-activated potassium (BK) channel or KCa1.1 channel, a major ion channel in the urinary bladder wall, which is made out of smooth muscle. Selective pharmacological targeting of BK channel with estrogen (17β-estradiol) may be very effective novel approach to treat over...

Preparation of Thermoplastic Epoxidized Polymers and Thermosetting Materials from Triglycerides

technology@sc.edu — Tue, 28 Jun 2016 08:18:14 GMT

Reference #: 01203The University of South Carolina is offering licensing for a method of preparation of thermoplastic epoxidized polymers and thermosetting materials from triglycerides. Background: Epoxidized soybean oils are commercially available and have been used as plasticizers in plastic industry. However, the preparation and application of epoxy resins from plant oils is still limited, due to the poor mechanical properties. This invention solves this problem detailing an alternative process/method for preparing epoxidized polymers. Invention Description:The subject invention is a simple...

Suppression of Self-Pulsing Regime of DC-driven Microplasma Discharge

technology@sc.edu — Tue, 28 Jun 2016 08:10:44 GMT

Reference #: 01196 The University of South Carolina is offering licensing opportunities for an instability suppressor circuit for self-pulsing DC driven micro-plasma discharge. Background: Micro-plasmas are plasmas of small dimensions, often within tens to thousands of micrometers in size. They are widely used for attaining non-thermal and non-equilibrium discharge at atmospheric and higher pressures since their small size is able to inhibit ionization overheating instability through rapid cooling. However, they are susceptible to instability from external disturbances, with external ...

Syngas Generator: Carbon Gasification Assisted Solid Oxide Electrolysis Cell

technology@sc.edu — Tue, 28 Jun 2016 07:51:32 GMT

Reference #: 01179 The University of South Carolina is offering licensing opportunities for a syngas generator that provides efficient and eco-friendly utilization of coal/biomass and CO2 to produce clean fuel and store energy. Invention Description: The subject invention is a carbon gasification (CG) assisted solid oxide electrolysis cell that can efficiently convert steam and carbon dioxide to syngas as a means of electricity storage and carbon dioxide utilization. This device also provides an eco-friendly and efficient way to use carbon-containing sources, such as coal and biomass, achievin...

Distance Learning: Invention for Student Activities via Robotic Telepresence Interaction

technology@sc.edu — Tue, 28 Jun 2016 07:37:47 GMT

Reference #: 01200 The University of South Carolina is offering licensing opportunities for a telepresence invention for student activities via robotic telepresence interaction. Background: Telepresence involves the use of virtual reality technology for remote control of equipment or for virtual participation in an event a place other than their true location. It makes it possible for participants to feel as if they were present or otherwise to give the appearance of being present. The telepresence technology has application in a variety of industries, with distance learning being one ...

Improvement and Optimization of Lentiviral Vectors for CRISPR/Cas9 Delivery

technology@sc.edu — Sun, 26 Jun 2016 18:17:50 GMT

Reference #: 01175 The University of South Carolina is offering licensing opportunities for an all-in-one CRISPR/Cas9 delivery platform with significant upregulation in vector production efficiency and gene expression. Invention Description: The subject invention is a delivery platform for use in gene editing that includes a relatively short, highly efficient promoter that drives transcription of a nucleic acid sequence that encodes a gene-editing molecule, e.g., either a gRNA or a nuclease. In conjunction with this promoter, the vector includes one or more transcription factor binding eleme...

Optical Displacement Sensing System Utilizing Edge Diffraction

technology@sc.edu — Sun, 26 Jun 2016 18:09:42 GMT

Reference #: 01113The University of South Carolina is offering licensing opportunities for novel edge diffraction-based displacement sensor with nanometer accuracy that can be easily implemented in high precision stage applications for machine tool metrology. Invention Description: The subject invention describes an inexpensive sensor that has a simple and non-contact sensing configuration while providing a high resolution. The proposed sensor showed a high linearity within 60µm range and the resolution 5.2nm. The electronic bandwidth of the sensor can easily exceed 1MHz. Potential...

Isotopically labeled three layer core-shell nanoparticles

technology@sc.edu — Sun, 26 Jun 2016 17:59:50 GMT

Reference #: 01100 The University of South Carolina is offering licensing opportunities for novel isotopically-enriched core-shell nanoparticles to quantify the respective roles of the particle and the ion from particle dissolution in bioaccumulation. Invention Description: Nanoparticles of between 10-50 nm in size can be made of pure metals or their oxides, alloys of two more metals (or oxides) or as core-shell nanoparticles. In this case, there are two layers of metals (or their oxides) which are pure phases of that component in each layer. The subject invention uses three layers and labels ...

A Reproducible Sample Preparation Method for Quantitative Stain Detection

technology@sc.edu — Sun, 26 Jun 2016 15:32:10 GMT

Reference #: 01146The University of South Carolina is offering licensing opportunities for a method that allows liquid stains to be created on fabric in a reproducible and constant manner that greatly reduces unwanted variability between samples of different dilution or fabric type.Invention Description: The subject invention is a stain-barrier that can be easily applied to fabric samples to limit the amount of fabric with which the deposited liquid is able to interact. This stain barrier greatly reduces unwanted variability between samples of different dilution or fabric type so that limits o...

MicroRNA-155 Enhances the Efficacy of Dendritic Cell Vaccine for Cancer

technology@sc.edu — Sun, 26 Jun 2016 15:23:48 GMT

Reference #: 01197The University of South Carolina is offering licensing opportunities for nanoparticle delivery tools (microRNA transfection) that enhance the efficacy of dendritic cell vaccines for cancer.Background:In anti-tumor immunity, dendritic cells (DCs) capture, process, and present tumor antigens to T cells, initiating a tumoricidal response. However, DCs are often dysfunctional due to their exposure to the tumor microenvironment (TME) as a result, dendritic cell vaccines developed for many cancers including breast cancer as immunotherapies have been ineffective. However, microRNA-1...

Cysteine-Modifying Substrate Analogue Inhibitors of Ribose 5-Phosphate Isomerase

technology@sc.edu — Sun, 26 Jun 2016 15:04:18 GMT

Reference #: 01181 The University of South Carolina is offering licensing opportunities for strong selective inhibitors of the ribose 5-phosphate isomerase enzyme as new drug alternatives to commonly prescribed therapies for Chagas’ disease, African sleeping sickness, and leishmaniasis.Invention Description: Kinetoplastid parasites such as Trypanosoma cruzi (T. cruzi), Trypanosoma brucei (T. brucei), and the Leishmania species utilize and depend on the pentose phosphate pathway (PPP) for survival. Obstruction of this pathway leads to cell death. This can be achieved by using drugs to inh...

Polymer-protein Core-shell Particles as Effective Vaccine Delivery Vehicles

technology@sc.edu — Sun, 26 Jun 2016 13:47:02 GMT

Reference #: 01168The University of South Carolina is offering licensing opportunities for a method to formulate protein-based antigens, especially glycoproteins-based antigens that enhance in vivo immune responses.Invention Description:The subject invention describes a novel vaccine delivery system using a self-assembled nanoparticle system. Protein-based antigens self assemble with proprietary, biocompatible polymers to form core-shell nanoparticles. Such nanoassemblies can induce much stronger immune responses as observed from in vivo studies.Potential Applications:Vaccine development...

Reproducible Sample Preparation Using 3D Printing

technology@sc.edu — Sun, 26 Jun 2016 11:51:52 GMT

Reference #: 01152 The University of South Carolina is offering licensing opportunities a method of 3D printing polymer boundaries that allows fast preparation of reproducible sampling areas on the fabric substrate sample materials while minimizing variability. Invention Description: The subject invention is a reproducible sample preparation method for 3D printed polymer rings that provide boundaries on different fabric types to hold liquid samples up to 500 uL. This allows liquid samples with different dilutions to spread uniformly within the same area. In addition, the rings also differe...

Repeat PSA Screening for Virulent Prostate Cancer

technology@sc.edu — Fri, 12 Feb 2016 12:30:31 GMT

Reference #: 01136 The University of South Carolina is offering licensing opportunities for an improved method of detecting high-risk prostate cancer that is able to distinguish it form non-virulent cancers as well as other conditions associated with elevated levels of prostate-specific antigens. Invention Description: The subject invention uses available repeat prostate-specific antigen (PSA) measures from the NCI-funded Prostate Lung Colorectal and Ovarian Cancer Screening Trial (PLCO) to predict subsequent diagnosis of clinically significant prostate cancer. Potential Applications:...

Polydopamine Coated PLGA Nanoparticle for Photothermal Therapy

technology@sc.edu — Thu, 19 Nov 2015 14:12:26 GMT

Reference #: 01169 The University of South Carolina is offering licensing opportunities for a biodegradable, photothermal-responsive nanoparticle that can be used for disease therapy, drug delivery, and other biomedical applications.Invention Description: The subject invention is a dual-functional, photothermal nanoparticle that not only delivers therapeutic agents to a target within the body but also generates heat under exposure to near-infrared (NIR) irradiation. The hybrid nanoparticle uses FDA-approved materials and includes a poly(lactic-co-glycolic acid) (PLGA) core and a polydopamine s...

Ceramic Nanofiltration Membranes Prepared by Molecular Layer Deposition

technology@sc.edu — Thu, 19 Nov 2015 13:30:22 GMT

Reference #: 01160The University of South Carolina is offering licensing opportunities for a method of preparing ceramic nanofiltration membranes using molecular layer deposition.Invention Description:The subject invention is a novel use of molecular layer deposition (MLD) to fabricate ceramic nanofiltration membranes, which offers excellent control of coating quality, thickness, and membrane pore sizes by utilizing self-limiting surface reactions at the sub-nanometer level. The resulting membrane’s pores are approximately 1 nm in size.Currently, ceramic nanofiltration membranes are usua...

Anti-diabetic Activity of Ciclopirox

technology@sc.edu — Thu, 19 Nov 2015 08:23:59 GMT

Reference #: 01154 The University of South Carolina is offering licensing opportunities for using Ciclopirox to treat diabetes and other conditions that involve the loss of glucose homeostasis.Invention Description: The subject invention is a novel use of Ciclopirox (also known as CPX, Loprox, or Ciclodan), an antibiotic used for fungal infections, to modulate glucose homeostasis, thereby regulating blood sugar levels that are responsible for many symptoms associated with diabetes. Potential Applications: CPX may be used for the treatment of diabetes, including but not limited to type I diabet...

The Preparation of Brain Targeted Nanoparticle and its Application

technology@sc.edu — Wed, 22 Jul 2015 06:27:01 GMT

Reference #: 01155 The University of South Carolina is offering licensing opportunities for a nanocarrier that can effectively pass the blood-brain barrier and deliver therapeutic drugs to diseased tissue by taking advantage of the physiological characteristics of brain. Invention Description: The subject invention is a dual targeted and dual responsive nanoparticle, which is able to cross the blood-brain barrier and release its payload in the brain tissue when it is triggered by the stimuli from the brain. The payload (i.e. the drug compound to be delivered to the brain) can be...

Pulsatile Perfusion Bioreactor Mimics, Controls, and Optimizes Blood Vessel Mechanics

technology@sc.edu — Wed, 22 Jul 2015 06:20:31 GMT

Reference #: 01147 The University of South Carolina is offering licensing opportunities for a perfusion bioreactor device that precisely controls and optimizes the mechanical environment for engineered vascular tissue. Invention Description: The subject invention describes a bioreactor that mimics, controls, and optimizes the mechanical loading and the physical properties of a range of native and engineered vascular tissues. It collects real-time mechanical and geometric data while enabling the tunability and optimization of signals including, but not limited to, flow-induced...

Optically Switched Graphene/4H-SiC Junction Bipolar Transistor (G-SiC BJT)

technology@sc.edu — Thu, 04 Jun 2015 12:25:04 GMT

Reference #: 01129The University of South Carolina is offering licensing opportunities for a novel bipolar transistor junction that is highly sensitive to UV light and useful for detection devices such as flame detectors, spectrometers, and missile tracking systems. The transistor may also be adopted for power electronic systems.Invention Description:The subject invention is a graphene/4H-Sic junction bipolar transistor (G-SiC BJT) designed to detect ultraviolet and nuclear radiation. It uses a highly transparent graphene layer to provide a low-loss radiation window while the transistor’...

The Preparation of Polymeric Prodrug of Disulfiram and its Application

technology@sc.edu — Tue, 20 Jan 2015 13:33:37 GMT

Reference #: 01145The University of South Carolina is offering licensing opportunities for a polymeric prodrug that is able to kill a broad-spectrum of cancer cells, including drug resistant cancer cells and cancer stem cells, without damaging normal cells.Invention Description:The present invention describes the preparation of a polymeric prodrug of disulfiram combined with copper ions that can effectively kill a broad-spectrum of cancer cells, including drug resistant cancer cells and cancer stem cells, at the nano-molar level. Potential Applications:Treatment of various cancers, as w...

Therapeutic Inhibitors of Hexokinase and Glucokinase

technology@sc.edu — Fri, 16 Jan 2015 11:48:26 GMT

Reference #: 01133 The University of South Carolina is offering licensing opportunities for new enzyme inhibitors for therapeutic drugs that treat diseases caused by trypanosomal parasites including Chagas’ disease and African sleeping sickness. Invention Description: Trypanosomal parasites, such as Trypansoma cruzi and Trypansoma brucei, utilize glycolysis, which is an essential energy-producing metabolic pathway. Since glycolysis is indispensable for these organisms, obstruction of the pathway leads to cell death. This obstruction can be achieved by inhibiting the hexokinas...

Schottky Barrier Detection Devices Having a 4H-SiC n-Type Epitaxial Layer

technology@sc.edu — Tue, 13 Jan 2015 12:20:06 GMT

Reference #: 1048 The University of South Carolina is offering licensing opportunities for a highly sensitive detector for low-energy x-rays, gamma rays, and high-energy particles. Invention Description: The subject invention is a detection device formed from Schottky diodes on 4H-SiC n-type epitaxial layers. It detects low-energy x-rays (50 eV to 10 keV), gamma rays, and high-energy particles such as electrons, alpha rays and heavy ions. Potential Applications: Optoelectronics Advantages and Benefits: 1. No commercially avail...

Assessment of Alkali-Silica Reaction in Concrete

technology@sc.edu — Tue, 13 Jan 2015 11:03:20 GMT

Reference #: 01124 The University of South Carolina is offering licensing opportunities for a non-intrusive method for detecting and classifying alkali-silica reaction in concrete structures. Invention Description: The invention is an algorithm for the detection and classification of alkali-silica reaction (ASR) in concrete structures. It is the first and only non-intrusive monitoring method that is used for this particular application. ASR is a chemical reaction occurring between alkaline hydroxides within cement paste and certain types of amorphous silica found in mine...

Hot Microcantilever-Based Selective Volatile Organic Compound (VOC) Sensor

technology@sc.edu — Mon, 12 Jan 2015 07:57:43 GMT

Reference #: 01139 The University of South Carolina is offering licensing opportunities for a microcantilever-based sensor that selectively detects volatile organic compounds which is not possible with current microscale sensors. Invention Description: The subject invention enables selective detection of volatile organic compounds (VOCs) using a microscale heater made of a wide bandgap semiconductor. The detection is performed at a much lower temperature compared to traditional hot-filament-based VOC detection techniques, enabling operation with low power consumption. This invention ad...

Supported, Bimetallic Nanoparticles for Selective Catalysis

technology@sc.edu — Tue, 06 Jan 2015 07:48:07 GMT

Reference #: 01131 The University of South Carolina is offering licensing opportunities for a bimetallic catalyst system that resists gold agglomeration (common with current carbon-supported gold catalysts) by combining a high surface free energy core metal with a controlled-thickness gold shell structure. Invention Description: The subject invention is a method of depositing gold (Au) nanoparticles on top of a series of pre-selected core metals to form a core-metal structure that is resistant to agglomeration. Potential Applications: · Hydrochlorination of acet...

Preparation Of Chemicals, Monomers And Polymeric Materials From Triglycerides

technology@sc.edu — Wed, 17 Dec 2014 09:01:40 GMT

Reference #: 01141 The University of South Carolina is offering licensing opportunities for a method of making chemicals, monomers, and polymers from plant oils that contain triglycerides. Invention Description: The subject invention provides facile approaches to preparing chemicals, monomers, and polymers from triglycerides. Chemicals and intermediates include esters, amides, alcohols, expoxides, etc. Monomers include acrylates, methacrylates styrenics, norbornenes, oxazolines, diols, diesters, etc. Polymers include homopolymers, random copolymers, graft copolymers, and block co...

Multiple Copolymer Systems as Templates for Block Copolymer Nanolithography

technology@sc.edu — Tue, 16 Dec 2014 11:43:02 GMT

Reference #: 01070 The University of South Carolina is offering licensing opportunities for novel linear block copolymers with lower molecular weight and feature size to prepare templates for nanolithography. Invention Description: The subject invention utilizes grafted block copolymers, star copolymers, and multi-segmented block copolymers to prepare microphase-separated films with extremely small feature sizes. These films can further be used to prepare templates for block copolymer nanolithography. Potential Applications: Microelectronics such as DRAM, circuits, ...

Preparation Of Conjugated Aromatic/Heteroaromatic Oligomer-Containing Dielectric Polymers And Their Applications

technology@sc.edu — Tue, 16 Dec 2014 11:42:52 GMT

Reference #: 01005 The University of South Carolina is offering licensing opportunities for conjugated aromatic/heteroaromatic, oligomer-containing polymers and their usage as high performance dielectric materials in the development of compact capacitors (with high energy density) for power electronics and pulse power applications. Invention Description: The subject invention prepares π-conjugated, aromatic/heteroaromatic, oligomer-containing, vinyl monomers and their polymers, and explores their usage as dielectric materials in capacitors for energy storage applicat...

Development of Polyvinylpyrrolidone Grafted Nanoparticles using New RAFT Agent

technology@sc.edu — Tue, 02 Dec 2014 13:29:16 GMT

Reference #: 01106 The University of South Carolina is offering licensing opportunities for a new RAFT agent to efficiently restore antibiotic activity by using synthesized nanoparticles. Invention Description: The subject invention is a new reversible addition-fragmentation chain-transfer (RAFT) agent to conduct the surface-initiated RAFT polymerization of N-vinyl pyrrolidone (NVP) on silica nanoparticles. Potential Applications: · Biomedical · Cosmetics · Drug delivery Adv...

Cortical-Bone-Like Microtubular Laminated Composite Scaffold Composition

technology@sc.edu — Tue, 02 Dec 2014 13:29:12 GMT

Reference #: 01013 The University of South Carolina is offering licensing opportunities for a degradable, cortical-bone-like construct that provides mechanical and nutrient support unlike metallic scaffolds, which remain in the implantation site and may eventually lead to device failure and tissue damage. Invention Description: The subject invention describes the composition, synthesis, and assembly of a set of bonded degradable microtubes that mimic the nano- and microstructure of cortical bone. Potential Applications: · All products used in o...

Polymer/Copper Combination for Cancer Targeted Therapy

technology@sc.edu — Mon, 24 Nov 2014 10:43:46 GMT

Reference #: 01140 The University of South Carolina is offering licensing opportunities for a polymer/copper formulation to treat cancer. Invention Description: The subject invention is a polymer/copper combination drug that can selectively kill a wide-spectrum of cancer cells without affecting normal cells. Potential Applications: Cancer treatment Advantages and Benefits: 1. Enhanced efficacy as a result of the combination of polymer and copper 2. Minimal side effects as a result of specific cancer cell selectivity 3. Lon...

A Novel Method of Preparing Lipamino Acids and Lipopeptides

technology@sc.edu — Thu, 20 Nov 2014 14:20:13 GMT

Reference #: 01107 The University of South Carolina is offering licensing opportunities for a single-pot, one-step process for synthesizing high yields of lipoamino acids and lipopeptides. These compounds exhibit antimicrobial activity that is useful in a wide range of applications such as pharmaceuticals and cosmetics. Invention Description: The subject invention is a method of synthetically producing high yields of lipamino acids and lipopeptides by combining a mixture of reactants, unlike conventional methods of production that require two steps or rely on i...

Preparation of Gold/Silica Hybrid Nanoparticle and Its Applications

technology@sc.edu — Mon, 10 Nov 2014 13:14:34 GMT

Reference #: 01130 The University of South Carolina is offering licensing opportunities for novel nanocarriers for disease detection, remotely controlled drug and gene delivery, and photothermal therapy. Invention Description: The subject invention is a fabrication method for a gold/silica hybrid nanoparticle that can be remotely controlled using NIR irradiation and remain stable after repeated exposure. Potential Applications: The potential applications for these nanoparticles include, but are not limited to, disease detection, drug and gene delivery, and photothermal therapy for cancer...

Marsh Restoration by Resuspension of Sediment by Hydraulic Jet

technology@sc.edu — Mon, 20 Oct 2014 14:11:11 GMT

Reference #: 01103 The University of South Carolina is offering licensing opportunities for a method of restoring elevation of marshes with sediment deficits by means of raising the concentration of suspended sediment.Invention Description: The subject invention is a device that raises the concentration of suspended sediment over the marsh during incoming tides. As the water floods over the marsh surface, the sediment settles on the surface and raises the elevation of the marsh.Potential Applications: Restoration and maintenance of tidal areas, such as marsh lands, creek beds, etc.A...

Superior Lithium Ion Battery Electrode and Methods for Fabricating Such

technology@sc.edu — Mon, 20 Oct 2014 14:11:09 GMT

Reference #: 01088 The University of South Carolina is offering licensing opportunities a single-step approach for synthesizing novel electrodes for lithium ion batteries in large quantities.Invention Description: The subject invention is a facile and scalable process to synthesize bulk electrodes for lithium ion batteries. These electrodes exhibit superior electrochemical properties and provide an ideal structure for lithium ion batteries that results in high power density, capacity retention, and overall improved performance.Potential Applications: Developing cost-effective anode materials f...

Synthesis of an Iron Analog of a Zeolite

technology@sc.edu — Tue, 30 Sep 2014 14:07:33 GMT

Reference #: 01101 The University of South Carolina is offering licensing opportunities for a new class of complete iron-based, zeolite analogs with three-dimensional frameworks.Invention Description:The subject invention represents the first examples of a zeolitic iron framework structure. These synthesized crystals are complete iron analogs of the basic zeolite known as sodalite. The presence of the transition element iron introduces electronic and magnetic properties to the iron-based zeolite crystal structure since the tetrahedral sites are all occupied by iron rather than by aluminum or s...

Method of Operating Hydrogen Pumps with High-Concentration Hydrogen Sulfides

technology@sc.edu — Thu, 07 Aug 2014 13:24:35 GMT

Reference #: 01018 The University of South Carolina is offering licensing opportunities for a method for purifying hydrogen from a hydrogen-containing gas stream that has hydrogen sulfide impurities.Invention Description: The subject invention is a method to purify hydrogen in the presence of high concentrations of hydrogen sulfide impurities using a hydrogen pump.Potential Applications: Hydrogen purificationAdvantages and Benefits: The invention is simple, requires little power, and has been shown to pump hydrogen to high pressures.Background: Hydrogen is an important gas for industrial...

Cyclodextrin Functionalized Nanoparticles for Quenching Bacterial Communications

technology@sc.edu — Tue, 05 Aug 2014 11:09:55 GMT

Reference #: 01089 The University of South Carolina is offering licensing opportunities for a novel method of combating bacterial infections without using antibiotics.Invention Description: The subject invention disrupts bacterial chemical communication using nanoparticles engineered with cyclodextrin compounds that bind and remove the molecules involved in chemical signaling. Potential Applications: AntibacterialAdvantages and Benefits:1. Controls bacterial growth without using conventional antibiotics, th...

A Novel Chemically Stable Ceramic-Metal Composite Membrane For Hydrogen Separation

technology@sc.edu — Tue, 05 Aug 2014 10:07:05 GMT

Reference #: 01092 The University of South Carolina is offering licensing opportunities for chemically stable, high performance permeation membranes to capture pure hydrogen.Invention Description: The subject invention provides a series of ceramic-metal composite membranes with high hydrogen permeation flux, mechanical strength, and chemical stability in H2O, CO2, and H2S-containing atmospheres. These membranes address the problems of state-of-art technology and are particularly useful for extracting hydrogen from any input streams with pressures between 1 and 1000 psi and temperatures b...

Catalyst Technology for One-Step Upgrading of Biomass-Derived Chemicals

technology@sc.edu — Mon, 14 Jul 2014 09:19:04 GMT

Reference #: 01019 The University of South Carolina is offering licensing opportunities for novel catalyst technology for biofuel production.Invention Description: The subject invention is a catalyst technology that combines the traditional method of removing oxygen from carbohydrates required for liquid fuels and the traditional method for forming long-chain molecules present in gasoline and diesel fuels into a single process that does not require liquid phase operations.Potential Applications: Biofuel production (e.g. liquid carbon production)Advantages and Benefits: 1. Scalable, single step...

Presaturation of Supercritical CO2 with Water for Decellularization of Matrices

technology@sc.edu — Mon, 07 Jul 2014 14:25:01 GMT

Reference #: 01079 The University of South Carolina is offering licensing opportunities for treating bioartificial tissues and similar materials with a novel cleaning solution.Invention Description:This subject invention is a cleaning solution that can be used in the production of artificial tissues and organs by dissolving water in carbon dioxide at a certain temperature and pressure. Unlike other solutions, which dry out the tissue and are rendered unsuitable for clinical use, this solution allows the tissue to retain its moisture and other native characteristics.Potential Applications...

Poly Alkyl (Meth)Acrylates Grafted Nanoparticles and Their Methods of Manufacture and Use

technology@sc.edu — Mon, 07 Jul 2014 14:15:38 GMT

Reference #: 01068 The University of South Carolina is offering licensing opportunities for a method of functionalizing nanoparticles with polyolefin-like polymers and dispersing them in polyolefins.Invention Description:The subject invention is a method of grafting polyolefin-like poly(meth)acrylates on inorganic nanoparticles in a controlled manner. This invention demonstrates further how to mix the poly alkyl (meth)acrylates-grafted nanoparticles with polyolefins like polyethylene and polypropylene to create nanocomposites with good dispersion.Potential Applications:Packaging and plastics s...

Polyisoprene Grafted Nanoparticles

technology@sc.edu — Mon, 07 Jul 2014 14:06:19 GMT

Reference #: 01058 The University of South Carolina is offering licensing opportunities for a method synthesizing polyisoprene grafted nanoparticles to prepare rubber on silica surfaces.Invention Description:The subject invention is a new method for polymerizing isoperene on silica nanoparticle surfaces that allows more dispersion of silica fillers in the rubber or polyolefin matrix.Potential Applications:Functionalization of rubber for improved mechanical propertiesAdvantages and Benefits:1. Enhances the mechanical properties of the resulting composite materials2. ...

Ultra-efficient Two-phase Evaporators/Boilers Enabled by Nano-tip-Induced Boundary Layers

technology@sc.edu — Mon, 07 Jul 2014 13:58:59 GMT

Reference #: 01037 The University of South Carolina is offering licensing opportunities for nanotip-induced boundary layers to enhance flow boiling in microchannels.Invention Description:The subject invention describes a method to make boundary layers created by nanotip arrays fabricated along the walls of microchannels that suppress flow boiling instabilities and control two phase flows and heat transfer.Potential Applications:Energy-efficient and cost-effective two-phase cooling systems in next-generation high-power electronics, 3D microelectronics, and high power photonicsAdvantages a...

Quantitative Acoustic Contrast Tomography for Studying Fungal Growth and Toxicity

technology@sc.edu — Mon, 07 Jul 2014 11:56:44 GMT

Reference #: 01080 The University of South Carolina is offering licensing opportunities for a minimally invasive technique that can provide accurate information of the mechanical and the morphological features of an entire landscape of an expanding fungal colony.Invention Description:The subject invention is can simultaneously study the structural, architectural, and material properties as well as the mechanical strength properties in a fungal colony. This can be used to predict levels of fungal invasion and toxicity under a given set of environmental conditions. The technology consists of a t...

Cracking of Platform Chemicals to Liquefied Petroleum Gas (LPG)

technology@sc.edu — Mon, 07 Jul 2014 11:38:17 GMT

Reference #: 01073 The University of South Carolina is offering licensing opportunities for a method to convert platform chemicals into liquefied petroleum gas in one-step with minimal energy input.Invention Description:The subject invention describes a one-step method of converting biomass platform chemicals into liquid petroleum gas (LPG) without using additional reactants. It uses platform chemicals as a renewable energy input, delivers bio-LPG with high conversion efficiency, and can be operated at moderate temperatures and atmospheric pressure. The resulting bio-LPG is a sustainable...

The Preparation of Triple Responsive Nanogel System and its Application

technology@sc.edu — Mon, 07 Jul 2014 10:37:44 GMT

Reference #: 01045 The University of South Carolina is offering licensing opportunities for a novel triple responsive drug delivery system in photodynamic cancer therapy.Invention Description:The subject invention is a triple responsive drug delivery nanogel (TRN) that selectively targets tumor tissue and self-expands to release its payload when triggered by changes of pH, redox potential, and temperature. Photosensitizer loaded nanoparticles showed enhanced photodynamic therapy (PDT) efficacy.Potential Applications:Anti-cancer drug delivery; photosensitizer delivery; photodynamic therap...

Sparstolonin B in Neuroblastoma Treatment

technology@sc.edu — Fri, 01 Nov 2013 08:20:59 GMT

Reference #: 01056The University of South Carolina is offering licensing opportunities for this novel treatment of neuroblastoma.Invention Description:This invention is derived from a novel, naturally occurring compound, Sparstolonin B (SsnB), which is isolated from the tubers of an aquatic Chinese herb, Sparganium stoloniferum. The crude extract prepared form this herb has anti-spasmodic and anti-tumor properties. Advantages and Benefits:• Significantly inhibits the growth of both MYCN-amplified and MYCN-non-amplified neuroblastoma cells.• Increased production ...

Fabrication of Magnetic Nanoparticles

technology@sc.edu — Mon, 28 Oct 2013 12:13:04 GMT

Reference #: 01023The University of South Carolina is offering licensing opportunities for this novel method of synthesizing iron oxide/silica core-shell magnetic nanoparticles.Invention Description:This invention is a new method to synthesize iron oxide/silica core-shell magnetic nanoparticles with a high saturation magnetization and controllable size under mild operation conditions, which is extremely significant for scale-up fabrications for industry uses. The traditional methods to prepare the iron oxide/silica shell magnetic nanoparticles cannot generate high magnetization nanoparti...

Novel Phosphonate/Phosphonic Acid RAFT Agents and Monomer Design

technology@sc.edu — Mon, 21 Oct 2013 07:29:34 GMT

Reference #: 01017The University of South Carolina is offering licensing opportunities for this novel use of binding nanomaterials and polymers.Invention Description:Polymer coated nanomaterials are useful in many applications, including in LEDs and bioimaging systems. However, the commercial use of nanomaterials is limited by the poor optical and mechanical properties of the composite when the nanomaterial and polymer are blended together. This invention provides for highly transparent and robust nanocomposites using polymers with special anchor points that bind extremely well with the ...

Control Algorithm for Protection Circuit for DC Power Distribution Systems

technology@sc.edu — Mon, 30 Sep 2013 11:40:39 GMT

Reference #: 01052The University of South Carolina is offering licensing opportunities for this novel technology that is useful in the rapidly proliferating field of dc power distribution systems. It protects circuits against short circuits while ensuring high power quality and power continuity to protected loads. Invention Description:This invention is an algorithm for controlling a specific (previously disclosed) electronic circuit “the hardware”. Together, the algorithm and the hardware assure delivery of high-quality power to loads in dc systems by protecting against common dis...

Method of Growing High Quality Epitaxial Graphene with Thickness Controllability

technology@sc.edu — Mon, 30 Sep 2013 10:32:33 GMT

Reference #: 01008The University of South Carolina is offering licensing opportunities for a method of achieving thin to thick graphene from a few monolayers to several microns with excellent surface morphology and uniformity, the combination of which is not realizable by other techniques.Invention Description:The subject invention is a novel method of growing epitaxial graphene by changing the silicon loss mechanism necessary for subsequent C-rich layers to form. This allows thickness and electronic properties to be controlled simultaneously, breaking the fundamental trade-off between crysta...

Purification of Colloidal Nanocrystals by Gel Permeation Chromatography

technology@sc.edu — Fri, 20 Sep 2013 11:40:00 GMT

Reference #: 01041The University of South Carolina is offering licensing opportunities for this novel method of purifying nanocrystals.Invention Description:The invention introduces a highly precise and effective gel permeation chromatography (GPC) purification technique, which can be used to prepare colloidal quantum dots (QDs) with well-defined surface characteristics. The inventors have found that it removes impurities that are not removed by a commonly used precipitation and redissolution methods that depend on solubility. Examples are presented for CdSe QDs and CdSe/CdxZn1-xS core/s...

Thermographic Imaging of Chemical Contrast via Differential Heating

technology@sc.edu — Tue, 06 Aug 2013 12:07:32 GMT

Reference #: 01006 The University of South Carolina is offering licensing opportunities for a method of detecting the presence of small amounts of a substance on a surface without using harsh chemicals or other damaging/hazardous techniques. Invention Description: Latent Heat Thermography is a technique that exploits differences in hydrophobic/ hydrophilic properties on a surface. Our process does not contaminate the sample. The top picture is a visible image taken with a cell phone camera; a 12’’ ruler is in the picture for a size reference. The acrylic fabric has 5 blood sta...

Anion-paired Cationic Metallocene-containing Compounds and Polymers as Antimicrobial Agents

technology@sc.edu — Thu, 25 Jul 2013 09:17:47 GMT

Reference #: 01016 The University of South Carolina is offering licensing opportunities for new types of cationic organometallic compounds and metal-containing polymers, or "metallopolymers," for drug-resistant, antimicrobial applications. Invention Description: The subject invention demonstrates the utilization of cationic metallocene moeities that exhibit antimicrobial properties when paired with a variety of different anions. These organometallic molecules and their charged metallopolymers inhibit a broad spectrum of pathogens, including Gram-positive and Gram-negative bacteria and many ki...

Switch Sanitizing Device

technology@sc.edu — Thu, 20 Jun 2013 12:09:09 GMT

Reference #: 01009 The University of South Carolina is offering licensing opportunities for devices that automatically sanitize switch surfaces using UV germicidal radiation to prevent transfer of communicable diseases from contaminated switch surfaces. Invention Description: The present invention addresses the need for sanitization or decontamination of the contact areas of manual switches by providing a localized source of germicidal electromagnetic radiation that is directed toward said contact surfaces via novel routing and shielding of said radiation. The device is designed in such a wa...

Self-Healing Catalysts for Oxidative Environments

technology@sc.edu — Thu, 20 Jun 2013 12:09:06 GMT

Reference #: 01031The University of South Carolina is offering licensing opportunities for a method of synthesizing self-healing catalysts that eliminate the need for periodic regeneration caused by catalyst deactivation.Invention Description:The subject invention achieves self-healing functionality by carefully controlling crystallographic facets exposed on the active catalyst surface to promote the reduction of oxidized species that cause deactivation.Potential Applications:Extending catalyst lifetimes in many catalytic reactions, such as CO2 mitigation and biomass upgrading, during which wa...

High-throughput Cell-free Assay for Detection of Quorum Sensing Signals, Acyl-Homoserine Lactones (AHLs)

technology@sc.edu — Tue, 19 Mar 2013 10:51:52 GMT

Reference #: 00653The University of South Carolina is offering licensing opportunities for high-throughput cell-free assay for detection of QS chemical signals.Background/Challenges:Quorum sensing (QS) is an emerging research field in health and environmental sciences during the past decade. QS is the ability of bacteria to communicate and coordinate behavior such as biofilm formation via signaling molecules called auto-inducers (e.g. acyl-homoserine lactones (AHLs)). Therefore, it is conceivable that quorum sensing inhibition represent a new, novel strategy to disrupt biofilm formation ...

Method and Apparatus for Online and Selective Measurement of Gas Permeation Through Polymer Films

technology@sc.edu — Mon, 18 Mar 2013 13:00:19 GMT

Reference #: 00761 The University of South Carolina is offering licensing opportunities for a novel method of measuring gas permeation. Invention Description: The invention is a method and a test system for measuring gas transmission rates through barrier materials, not only in single gases but also for gas mixtures. The test system consists of a continuous flow permeation cell, a mass spectrometer with electron multiplier, gas supplies, flow controls and software for online data acquisition. The temperature and relative humidity of the gases are also controlled. A quadrupole mass spe...

Disposable Handle

technology@sc.edu — Tue, 05 Feb 2013 09:33:39 GMT

Reference #: 00970 Background: According to Center for Disease Control & Prevention (CDC) statistics, approximately 1.7 million Americans contract infections during hospital stays, and 99,000 deaths are attributed to these infections each year. Most of these hospital-acquired infections could be avoided if hospitals maintained stricter infection control measures. Simple strategies such as washing hands before touching each patient and making sure bedding is cleaned, for example, go a long way to ensure a safer environment. The risk of acquiring infection in healthcare facilities (HAI) ...

Sterility Barrier for Ultrasound-guided Procedures

technology@sc.edu — Tue, 05 Feb 2013 09:33:39 GMT

Reference #: 00987Background:Frequently, ultrasound procedure kits are used for sterility purposes to prevent infection when skin puncture is necessary for ultrasound guided procedures. These kits can include a sterile ultrasound probe cover, sterile gel, and drape, but are expensive and time consuming to use. Ultrasound trained practitioners who routinely perform procedures such as removing fluid from the lungs or an arthritis joint or placing medicine into a joint need to have some way to prevent contamination of the sterile area of the skin puncture site to prevent infection. Instead of usi...

Silicone Based Nanocomposites Including Inorganic Nanoparticles and Their Methods of Manufacture and Use

technology@sc.edu — Tue, 05 Feb 2013 09:33:37 GMT

Reference #: 00992 Background: Compared with pure silicone polymer, silicone-based nanocomposites can realize enhanced mechanical, thermal, electric, dielectric and optical properties by adding functional inorganic nanofillers. However, the incompatibility between inorganic nanofillers and an organic matrix normally leads to large agglomerates of the inorganic nanofillers within the polymer matrix. The agglomeration leads to a loss in optical transparency and severely limits the use of these materials in optical applications. This is especially true for silicone nanocomposites because the sur...

Bio-inspired Polymeric Additive for Strength and Deformability Enhancement of Cementitious Composites

technology@sc.edu — Fri, 25 Jan 2013 13:18:38 GMT

Reference #: 00924 The University of South Carolina is offering licensing opportunities for an in situ biopolymer reinforcing agent for use in stronger, better performing cement mortar. Invention Description: The subject invention involves the successful incorporation of a bio-inspired additive in the mix design of cement pastes, yielding an average increase in compressive strength and axial deformation at peak load in excess of 75% and 110%, respectively. This enhancement in performance can be attributed to the strong chemical bond between the polymer’s functional groups and the metal...

Incorporation of Plant Virus Particles and Polymers as 2D and 3D Scaffolds to Manipulate Cellular Behaviors

technology@sc.edu — Thu, 10 Jan 2013 12:10:30 GMT

Reference #: 00990 Invention Description:This invention provides procedures for coating surfaces with protein particles purified from plant hosts as well as protein expression systems and procedures for using these protein-coated surfaces to accelerate tissue regeneration/repair. It also includes methodologies for stably incorporating various biologically active groups on the protein particles, immobilizing the proteins on various surfaces, culturing cells using specific media recipes and rapidly obtaining bone-like tissues. Background:A major focus in biomedical research is the utilizat...

Compositions of Degradable Salt-Responsive Copolymers

technology@sc.edu — Tue, 20 Nov 2012 11:45:43 GMT

Reference #: 00974 Invention Description: The subject invention is a method of making salt-responsive, water-dispersible, 100% biodegradable, cationic co-polymers and their applicability as binder compositions. The invention provides an entirely new approach to develop new binder compositions for personal care products such as baby diapers, incontinence products, tissues and wet wipes, and feminine hygiene products. Successful implementation of these polymers will enable replacement of some non-degradable acrylic polymers used as the standard today. Advantages and Benefits: The copolyme...

Method and Apparatus for Improved Mixing of Solid, Liquid or Gaseous Material and Combinations Thereof

technology@sc.edu — Tue, 13 Nov 2012 09:40:22 GMT

Reference #: 00960 Invention Description: The subject invention is a method and apparatus for improved mixing of solid, liquid or gaseous materials. Improved mixing is achieved by a novel arrangement of the mixer impellers that yields ideal mixing without the use of baffles and without torque being transmitted to the vessel walls. Potential Applications: · Food processing (industrial and personal) · Kitchen stick mixers · Contractor grade mixers for grout, paint, e...

III-V Nitride Microcantilever based Photoacoustic Biosensor

technology@sc.edu — Wed, 31 Oct 2012 08:01:58 GMT

Reference #: 00978 The University of South Carolina is offering licensing opportunities for this novel biosensor for use in detecting cancer cells in blood samples.Invention Description:The subject invention is a highly sensitive and miniaturized biochip sensor capable of detecting a single melanoma cancer cell in circulating blood samples. The pre-clinical and clinical applications in detecting cancer metastasis and prognosis are extensive. The biochip sensor utilizes the photo-acoustic detection technique to differentiate cancer cells from other cells present in blood in a label-free manner,...

Hydrolysis Reactor for Hydrogen Production

technology@sc.edu — Tue, 30 Oct 2012 13:31:33 GMT

Reference #: 00677 Invention Description: This technology deals with the production of hydrogen using hydrides. It is a method and reactor configuration for treating a chemical hydride with water at an elevated temperature to cause a reaction (hydrolysis) between the hydride and the water to produce hydrogen. The technology is also a novel method for delivering a hydride to a reaction zone in a manner that allows rapid reaction of a hydride with water to produce hydrogen. Advantages and Benefits: This technology does not require acid or a heterogeneous catalyst for hydrolysis to occur. It p...

Soft Reclosing Method for Service Restoration in a Power System

technology@sc.edu — Fri, 12 Oct 2012 12:46:01 GMT

Reference#: 00976 Invention Description: This invention is a process for using inverter-coupled local energy storage to softly restart an industrial power network after a grid outage. The soft restart process eliminates a number of problems commonly associated with simply reclosing a circuit breaker -- problems such as large inrush currents, motor torque pulsations, and voltage dips on the power line feeding the plant. The soft restart process applies a specific protocol to pre-energize or rapidly re-energize the network while still in islanded mode, and then to reclose the circuit breaker on...

Novel Electrocatalyst Support and Catalyst Supported Thereon

technology@sc.edu — Tue, 18 Sep 2012 14:31:27 GMT

Reference #: 00568Invention Description:The subject invention is a novel electrocatalyst support for use in fuel cells and other electrochemical applications. It offers a catalyst support material that can easily be used in place of carbon. The intellectual property also outlines the process for synthesizing the electrocatalyst support. Advantages and Benefits:· High surface area electrocatalyst, provides improved polarization performance over traditional carbon supports · Composition of the...

Methods and Systems for Determining Entropy Metrics for Networks

technology@sc.edu — Tue, 18 Sep 2012 14:31:25 GMT

Reference #: 00546 Invention Description: The subject invention is a method for the reduction of large network connection matrices to far less numbers of variables, thus constituting an invention of new "entropy matrices for the network". Potential Applications: The use of such intellectual property or technology is for the classification and tracking of the behavior of complex systems over time to identify failures, attacks, major structural changes in the topology, and other variance within Internet Networks. Advantages and Benefits: Reduction of large networks to a few representativ...

Graphite as NO2 Sensor Using Surface Work Function Changes

technology@sc.edu — Tue, 18 Sep 2012 06:27:34 GMT

Reference #: 00645 Invention Description: This invention is a novel sensor based on electromechanical principles using a resonant microcantilever. It can be used for detecting volatile chemicals, toxic gases, and bio-agents. The technology is based on a highly economical film deposition technique on a substrate (as opposed to the cantilever that is normally used) to create a surface that is highly sensitive and selective to various target gases. Potential Applications: This invention will be used for toxic gas sensing, pollution control, bio-hazard detection, and counter terrorism/hom...

Synthesis of a Highly Crystalline, Covalently Linked Porous Network

technology@sc.edu — Tue, 18 Sep 2012 06:27:33 GMT

Reference #: 00558 Invention Description: A covalently–linked, microporous, extended network with persistent pores has been synthesized and characterized. The synthesis is straight-forward without the need for the addition of any catalysts or reagents beyond the principle building blocks. The yields are good and the isolation facile. Spectral characterization has confirmed the bonding motif to generate infinite 2D porous sheets while PXRD was used to define the long range ordering of these sheets, such that atoms in adjacent layers lie directly over each other. This formation results i...

A Novel Screen of PAD4 Inhibitors

technology@sc.edu — Tue, 18 Sep 2012 06:27:33 GMT

Reference #: 00689 Invention Description: The subject invention is an Activity-Based Protein Profiling (ABPP) assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to PAD4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the assay. Potenttial Applications: Protein Arginine Deiminase 4 (PAD4) is a leading target for the development of a Rheumatoid Arthritis (RA) pharmaceutical. Advantages and Benefits: Overcomes the limitations of commonly used PAD4 assays by elimi...

(Disease Resistance) - A Method of Enhancing Systemic Acquired Resistance in Plants

technology@sc.edu — Tue, 18 Sep 2012 06:27:33 GMT

Reference #: 00194The University of South Carolina is offering licensing opportunities for this method of generating tobacco plants that are less susceptible infection.Invention Description:This invention specifically provides an alternate use for the booster sequence in tobacco plants. The use of the booster sequence will suppress the immune system (post transcriptional gene silencing) but its supplication to plant material also induces general and induced resistance to plant pathogens such as viruses or fungi. (P1/HC-Pro lines have an enhanced Systemic Acquired Resistance response.) In o...

An endogenous regulator of RNA silencing in plants

technology@sc.edu — Tue, 18 Sep 2012 06:27:32 GMT

Reference #: 00454 Invention Description: The subject technology is a technique or method for altering gene expression in plants by regulating an endogenous mechanism called RNA silencing (or RNA interference-RNAi). A certain transcription factor was discovered which, when overexpressed, delays the onset of RNA silencing, thus allowing longer expression of the silenced gene. Conversely, when the expression of this same transcription factor is decreased by various means, the plants silence more rapidly and more effectively. This invention includes the identification of a tobacco protein (terme...

Embedded-Ultrasonic Structural Radar (EUSR) with Piezoelectric Wafer Active Sensors (PWAS) for Wide-Area Nondestructive Evaluation of Thin-Wall Structures

technology@sc.edu — Tue, 18 Sep 2012 06:27:30 GMT

Reference# 00327 Invention Description: The subject invention is a method and device for performing ultrasonic damage detection in a thin-wall structure using an array of embedded Piezoelectric Wafer Active Sensors (PWAS). Background: It has been recognized that there is a need to monitor the structural health of various types of equipment (i.e. vehicles, machines, aircraft, oil tanks, pipelines, and critical pressure vessels used in the energy generating industry). A variety of techniques have been utilized to perform nondestructive evaluation of structures. For example...

Multi-dimensional Integrated Detection and Analysis System (MIDAS)

technology@sc.edu — Tue, 18 Sep 2012 06:27:30 GMT

Reference #: 00681Invention Description:The present invention is a novel Multidimensional Integrated Detection and Analysis System (MIDAS) which leads to the development of robust, versatile, and inexpensive sensors based on a nano-structured graphite and/or Graphene functionalization layer that can be put very easily and economically on a variety of substrates. The system uniquely integrates potentiometric and capacitive detection techniques with the commonly used amperometric technique for highly sensitive, expedient, and accurate detection of target molecules.Advantages and Benefits:Traditi...

Cartesianal Approach to Localized Electric Field Application and Harvesting Within a Continuous Medium

technology@sc.edu — Tue, 18 Sep 2012 06:27:29 GMT

Reference #: 00587The University of South Carolina is offering licensing opportunities for this innovative method for actuating localized electric fields with large reductions in wiring within a continuous array of sensors.Background:Structural health monitoring (SHM) is an emerging field in which smart materials interrogate structural components to predict failure, expedite needed repairs, and thus increase the useful life of the components. In the application of this technological approach, the use of the piezoelectric materials to convert electrical signals into acoustic energy (and v...

Energy Storage from Cellulose Fiber Materials

technology@sc.edu — Tue, 11 Sep 2012 07:12:01 GMT

Reference #: 00964 Invention Description: The subject invention consists of activated carbon textiles (ACTs) for energy storage applications. The invented ACTs are highly conductive and flexible, enabling an ideal electric double layer capacitor (EDCL) performance. For this invention, asymmetric super-capacitors were assembled with the ACTs as the negative electrode and the hybrid MnO2/ACT composite as the positive electrode. Potential Applications: · Textile super-capacitors · Fiber super-capacitors · Other textile based energ...

Method of Making Homogeneously Porous Solid Matrix with Tunable Porosity and Pore Size

technology@sc.edu — Tue, 04 Sep 2012 11:18:17 GMT

Reference #: 00961 The University of South Carolina is offering licensing opportunities for a Method of Making a Homogeneously Porous Solid Matrix with Tunable Porosity and Pore Size. Invention Description: The subject invention is a method of making homogeneously porous ceramics. The process is based on the co-precipitation method and allows for the explicit control of the porosity and pore size. The demonstrated sacrificial template methodology provides an alternative means of tailoring properties of a porous ceramic for particular applications in catalysis, fuel c...

System to Reverse Engineer Computer Application Screens

technology@sc.edu — Tue, 04 Sep 2012 08:17:57 GMT

Reference #: 00680 The University of South Carolina is offering licensing opportunities for this copyright. Potential Applications: Allows recreation of: Legacy software Software where the source code has been lost Software where the source code is no longer compatible with modern programming languages Advantages and Benefits: Automates tedious recreation of a software’s user interface. Invention Description: The traditional approach to reverse engineering a software application focuses on the underlying logic instead of the user interface. Since the user interface is v...

Robust Stereo Calibration System and Method for Accurate Digital Image Correlation Measurements

technology@sc.edu — Wed, 22 Aug 2012 13:21:36 GMT

Reference #: 00612The University of South Carolina is licensing a stereo calibration method for accurate digital image measurements in multi-media applications. This method allows users to employ standard optical equipment to measure accurately the motion and strain of an object immersed in a medium that is different from the one in which the measurement equipment is located. The method can be used with a variety of measurement systems and interfaces.Problem:It is difficult to measure motion and strain accurately for objects that are immersed in a medium that is different from the medium in wh...

Dual Secured Therapeutic Peptide Delivery System for Cancer Therapy

technology@sc.edu — Tue, 21 Aug 2012 13:53:34 GMT

Reference #: 00925 The University of South Carolina is offering licensing opportunities for a therapeutic peptide delivery system for cancer treatment that can specifically target tumor tissue while being non-toxic to red blood cells. Background: The National Institutes of Health estimated that the annual costs of cancer top $226 billion. Researchers are dedicated to finding better treatments and have extensively explored therapeutic peptides (e.g. melittin) because they have wide-spectrum lytic properties and are less likely to develop resistance. However, their ...

M13 Bacteriophage as a Chemoaddressable Nanoparticle for Sensing and Cell Culturing

technology@sc.edu — Tue, 21 Aug 2012 07:11:01 GMT

Reference #: 00749Invention Description:The present invention is the use of M13 bacteriophage for cell targeting, cell imaging, drug delivery vehicle, and bio-scaffold able to direct cell growth.Potential Applications:Can be customized for various therapeutic applications: bio-imaging (use of fluorescent dyes, magnetic contrast imaging agents) cell targeting molecules (use of boronic acids, folic acid, antibodies) drugs at high local concentrations to increase detection sensitivity and efficacy for therapeutic applications Advantages and Benefits:Provides a wide array of shapes as rods and ...

Improved Method for Industrial Scale Micropropagation of Select Monocots (Arundo, Miscanthus & Scirpus) based on Sustained Totipotent Cell Cultures

technology@sc.edu — Thu, 16 Aug 2012 14:19:45 GMT

Reference #: 00631The University of South Carolina is offering licensing opportunities for this technology.Invention Description:This invention provides a new alternative, improved, comprehensive set of methods for the initiation, mass micro-propagation, maintenance, storage, transportation, deployment of propagules as well as for enhanced somaclonal breeding of select plant species utilizing an improved sustained embryogenic cell culture induction and maintenance technology and the derived secondary totipotent cell cultures and tertiary microtillering multishoot cultures, where t...

CEMIA - Compact Electromechanical Impedance Analyzer for Structural Health Monitoring

technology@sc.edu — Thu, 16 Aug 2012 13:42:32 GMT

CEMIA - Compact Electromechanical Impedance Analyzer for Structural Health Monitoring

Development of novel method for preparation of PEM fuel cell electrodes

technology@sc.edu — Thu, 16 Aug 2012 13:42:30 GMT

Reference #: 00437 The University of South Carolina is offering licensing opportunities for this technology. Potential Applications: The present invention relates to a multi-layer polymer electrolyte membrane, an electrochemical apparatus and a process for the preparation of a multi-layer polymer electrolyte membrane. These types of PEM fuel cell membranes are used in devices such as hydrogen or direst methanol fuel cells. The technique can be used for the deposition of platinum as well as other noble metals (Ru, Pd, Ag, etc,) and alloys such as Pt-Ru, Pt-Ir, Pt-Ag an...

StationView - (Comprehensive Management System for Managing the National Geodeic Survey Control Stations)

technology@sc.edu — Thu, 16 Aug 2012 13:42:29 GMT

StationView - (Comprehensive Management System for Managing the National Geodeic Survey Control Stations)

Additive for Enhanced Hydrogen Adsorption/Desorption Kinetics in Complex Hydrides

technology@sc.edu — Thu, 16 Aug 2012 13:42:28 GMT

Reference #: 00395 The University of South Carolina is offering licensing opportunities for this technology. Invention Description: This technology is a new method for producing doped metal hydride compounds that has been shown to improve hydrogen storage characteristics. Advantages and Benefits: The method is an improvement from the traditional ball milling techniques and achieves enhanced distribution and uniformity of materials. As a result, the composition is a fused combination of dopants and metal hydrides. The fused compositions have excellent physical stability and desirable absorptio...

Reversible Hydrogen Storage Materials

technology@sc.edu — Thu, 16 Aug 2012 13:42:27 GMT

Reference #: 00626The University of South Carolina is offering licensing opportunities for this technology.Invention Description:The subject invention is a unique material designed to provide improved handling and the reversible storage of hydrogen. Potential Applications:One area of application of this invention is as on-board hydrogen storage systems for Fuel Cell vehicles (FCV).Advantages and Benefits:· Can be made quickly and cheaply from readily available chemicals· Have very reasonable charging and dischargin...

A Method of Eliminating Forward Voltage Drift in SiC PiN and PN Diodes

technology@sc.edu — Thu, 16 Aug 2012 13:42:26 GMT

Reference #: 00385 The University of South Carolina is offering licensing opportunities for this technology. Invention Description: This invention is a novel method for fabricating SiC PiN and PN diodes that do not experience voltage drift during operation. This new process involves the formation of a linearly graded, deep pn junction resulting from diffusion of acceptor impurity into a substrate, particularly a SiC substrate. Inventors have discovered that a deep and linearly graded doping concentration profile in the pn junction region reduces or eliminates degradation of forwa...

(HC PRO) - Plant Viral Genes Capable of Boosting the Replication of a Broad Range of Other Viruses

technology@sc.edu — Mon, 13 Aug 2012 14:07:34 GMT

Reference #: 00126 The University of South Carolina is offering licensing opportunities for this technology Invention Description: The subject invention is a method of inactivating the plants natural immune response in order to get desired levels of gene expression. The invention also consists of the identification of a plant virus genomic sequence, which can boost the replication, and accumulation of a broad range of other plant viruses. Potential Applications: The primary potential application for this technology is in the field of therapeutic protein production (antibodies, va...

(AMPLICON - HCP+) - A Method for High Level Expression of Gene Products in Plants

technology@sc.edu — Mon, 13 Aug 2012 14:07:34 GMT

Reference #: 00211 The University of South Carolina is offering licensing opportunities for this technology Invention Description: This invention is a method of increasing the expression of a desired gene product. Compared with USC Tech Id#126, here the target gene or sequence is silenced, which prevents the production of gene products. Therefore, the plant’s natural immune system (cosuppression) is intentionally activated. Potential Applications: The subject methods can be used to produce peptides or proteins that cannot effectively be expressed in mammalian s...

Nondestructive Defect Delineation in SiC Wafers Using Optical Stress Technique

technology@sc.edu — Mon, 13 Aug 2012 14:07:34 GMT

Reference #: 00367 The University of South Carolina is offering licensing opportunities for this technology Invention Description: This invention is cost-effective, rapid, and nondestructive characterization technique, which can be used for fast and routine SiC wafer-scale evaluation of structural and crystallographic defects. The technique employed by this invention can easily locate and map the various defects in SiC wafers by magnifying the defect to tens of hundreds of micrometers in dimension. Problem Solved: Recent investigations have shown the great potential of silicon ca...

Synthesis of Functional Nanowires via Virus Assembly

technology@sc.edu — Mon, 13 Aug 2012 14:07:33 GMT

Reference #: 00592The University of South Carolina is offering licensing opportunities for this technology.Invention Description:The technology is a method to synthesize one-dimensional nanostructures or “nano-wires” based on the self-assembly of the tobacco mosaic virus (TMV). Potential Applications:Primary potential applications include: the generation of highly ordered and programmable anisotropic structures and the assembly of TMV into various customizable nanostructures. The resulting nanostructures have many areas of use including electronics, optics, sensing and biomed...

Artificial Myocardium

technology@sc.edu — Mon, 13 Aug 2012 14:07:33 GMT

Reference #: 00166 Invention Description: This invention is a 3-dimensional, multilayered, functional, artificial myocardium. The subject invention is composed of appropriate extracellular matrix (ECM), nutritional requirements, a critical ratio of myocytes and fibroblasts, all in an in vitro environment. Potential Applications: · Implantation to repair or patch focal structural defects of the ventricular wall · Augmentation of existing muscle · Correction of muscle defici...

A Method for Decomposing Toxic Organic Pollutants

technology@sc.edu — Mon, 13 Aug 2012 14:07:31 GMT

Reference #: 00167 Invention Description: The subject invention is the use of an enzyme produced by Spartina alterniflora to degrade halogenated organics. Potential Applications: · Remediation of soils contaminated with halogenated organics such as TCE · Removal of toxic organic pollutants from municipal, industrial, agricultural or military sources in water and soil that need to be decomposed, removed and/or stabilized. Advantages and Benefits: · Low cost · &n...

In-situ structural health monitoring, diagnostics, and prognostics system utilizing smart active sensors with embedded intelligence and wireless installation

technology@sc.edu — Mon, 13 Aug 2012 14:07:30 GMT

Reference #: 00284 The University of South Carolina is offering licensing opportunities for this technology Invention Description: This invention provides an in-situ sensor system for structural material non-destructive evaluation (NDE). This in-situ structural health monitoring, diagnostics, and prognostics system utilizes unobtrusive arrays of smart active sensors with embedded intelligence. These sensors, called Piezoelectric Wafer Active Sensors (PWAS), use wireless communication technology for remote supervision, health monitoring, and damage detection while exam...

Total Synthesis of (+)-Fusarochromanone

technology@sc.edu — Mon, 13 Aug 2012 14:07:29 GMT

Reference #: 00365.01 The University of South Carolina is offering licensing opportunities for this technology Invention Description: This invention is the total synthesis of Forsarochromanone (FC-101), a metabolite of the fungus Fusarium equiseti. This substance is a potent inhibitor of angiogenesis, which is the formation of new blood vessels from existing ones. This process plays a key role in several pathological conditions, including cancer, heart disease and arthritis. The route that was employed in the total synthesis of this natural product is convergent. The longest line...

Co-based Catalysts Supported on Modified Carbon Substrates for PEMFC Cathodes

technology@sc.edu — Tue, 07 Aug 2012 13:16:27 GMT

Reference #: 00517 Potential Applications: The catalyst from this invention can be utilized as a cathode electrocatalyst in a PEM fuel cell. Such a fuel cell could be utilized for various applications, including power sources for electric vehicles. in such electric vehicles, high power output and stability are of great importance, and the cathode catalyst from this invention is advantageous in that regards. Advantages and Benefits: 1. Has remarkably high catalytic activity 2. A high onset potential for ORR 3. Demonstrates current densities that...

Metal-free Carbon Catalysts for Oxygen Electroreduction in PEMFC Cathodes

technology@sc.edu — Tue, 07 Aug 2012 13:16:26 GMT

Reference #: 00527Intellectual Property status:Patent has been issued for this technology: U.S. Patent 7, 629, 285. The University of South Carolina is offering licensing opportunities.Potential Applications:Can be used as a catalyst in a PEM fuel cell.Advantages and Benefits:This metal-free carbon catalyst is cheaper to produce than the traditional metal based ones. This technology produces the same four-electron pathway as a metal catalyst for oxygen reduction reaction while also increased activity and selectivity, with no performance degradation in the fuel cell using this tech...

Polymer-Coated Silver Vanadium Oxide for High Performance Primary Lithium Batteries

technology@sc.edu — Tue, 07 Aug 2012 13:06:42 GMT

Reference #: 00522 Invention Description: Traditionally silver vanadium oxide (SVO) is used as a positive electrode in lithium batteries due to its high gravimetric/volumetric energy densities. There are two methods to producing SVO, the decomposition method and combination reaction method. This invention utilizes the combination reaction method to achieve a high performance polymer/SVO composite. It is an object of the present invention to provide a novel method of synthesizing hybrid composites of a specific polymer and SVO to increase discharge capacity and improve rate capability...

High-Efficiency, Non-Toxic Scrubber for Removing Carbon Dioxide from Atmospheric Air

technology@sc.edu — Mon, 16 Jul 2012 10:11:24 GMT

Reference #: 00712 The University of South Carolina is offering licensing opportunities for a high-efficiency and non-toxic CO2 scrubbing system configured to remove the variable CO2 in atmospheric air. Potential Applications: This technology can be used to improve efficiency and consistency of processes using CO2 scrubbing systems. Advantages and Benefits: Is highly efficient and non-toxic Provides for stringent control of pCO2 Removes the variable CO2 in atmospheric air Problem: Given the massive use of fossil fuels to provide energy for our world population, concerns about the ...

A Method to Increase and Control Carrier Lifetime in SiC

technology@sc.edu — Mon, 09 Jul 2012 13:40:51 GMT

Reference #: 00694 Invention Description: This invention is a method to use Silicon Carbide (SiC) epilayers for bipolar devices, which gives the user control of the carrier lifetime. Background: Until now, there has been no method for controlling or improving the carrier lifetime using the Chemical Vapor Deposition (CVD). Carrier lifetime is a key parameter of bipolar devices. A long life is useful for modulating the conductivity, while a shorter lifetime is better for switching devices with lower switching losses. Therefore, it is incredibly important to have a controlled process where ...

Specific Gene Polymorphisms in Cancer Disease Diagnosis, Prevention and Treatment

technology@sc.edu — Mon, 09 Jul 2012 13:40:50 GMT

Reference #: 00687 The University of South Carolina is offering licensing opportunities for a direct nucleotide sequencing strategy that identifies polymorphisms of CD44, which may account for 80% of breast cancer cases. Potential Applications: This nucleotide sequencing strategy is used in the prevention, diagnosis, and treatment of breast cancer. Advantages and Benefits: Aids in the diagnosis of breast cancer at earlier stages leading to higher survivability Identifies CD44 polymorphism which may account for 80% of breast cancer cases Background: Currently, two breast c...

A MOS-driver Compatible JFET Structure with Enhanced Gate Source Characteristics

technology@sc.edu — Thu, 05 Jul 2012 12:52:41 GMT

Reference #: 00780 Invention Description: This invention is a modified Junction Field Effect Transistor (JFET) gate structure that allows the gate to be driven by a conventional Metal Oxide Semiconductor Field Effect Transistor (MOSFET) gate driver. Prior-art JFETs have different gating requirements from MOSFETs because of the diode between gate and source. This invention reduces the amplitude of the gate current needed to control the device because in the present invention the gate current is a unipolar current (only one carrier type), rather than a bipolar current (both carrier types...

Encapsulation and Controlled Release of Small Molecules for Intracellular Delivery using Thermally Responsive Nanocapsules

technology@sc.edu — Thu, 05 Jul 2012 12:52:41 GMT

Reference #: 00779 Invention Description: This invention is a thermally responsive nanocapsule-mediated approach for delivering a significant amount of trehalose (342 Dalton) or other small molecules (< 1 kilo Dalton) into eukaryotic mammalian cells (e.g., NIH 3T3 fibroblasts). The construction of these capsules allows them to change size, surface charge, and wall permeability based on ambient temperatures. The temperature sensitive wall permeability and size also allows the capsules to be loaded with a desired substance that would otherwise not be transferable to the interior of the cel...

Multi-Dimensional Credentialing Using Veiled Certificates

technology@sc.edu — Thu, 05 Jul 2012 12:52:41 GMT

Reference #: 00772 Invention Description: In a time when securing personal information is of utmost importance, this system is the newest level of internet protection. The veiled certificate (VC) is the only credential approach that satisfies regulatory and reporting needs, while at the same time functions as an anonymous, multi-dimensional credentialing tool. The VC makes it possible for third-party recipients to authenticate individuals’ credentials (e.g. social security number and proof of insurance) without providing direct access to the information. Third party recipients ca...

Chloroacetamidine-based Inhibitors and Activity-based Probes for the Protein Arginine Methyltransferases

technology@sc.edu — Thu, 05 Jul 2012 12:52:40 GMT

Reference #: 00771 Invention Description: The present invention is a potent, irreversible inhibitor, targeting protein arginine methyltransferase 1. Inhibition studies have demonstrated that the inhibitor is a potent and selective inactivator of the enzyme. This inhibitor covalently modifies an active site residue on the enzyme. Potential Applications: This inhibitor could be a vital tool in the treatment of heart and vascular diseases. By regulating the levels of ADMA, NO synthesis can be increased, leading to improved vascular homeostasis. It is also believed that this inhibitor, or a ...

Sit to Stand Transfer Data Collection

technology@sc.edu — Thu, 05 Jul 2012 12:52:40 GMT

Reference #: 00770Background:Health care needs and costs are estimated to rise in parallel with the rapidly growing aging population. When an older adult becomes dependent or disabled, family and health care providers experience significant financial, personal, and emotional burdens. Using indicators to predict approaching disabilities in older adults will allow for intervention and prevention, thereby reducing the burdens and costs associated with adult dependency. For instance, the capacity to stand up from a chair is an indicator of physical motor capabilities for older adults.Invention Des...

A Method to Synthesize Porous Hollow Metal Oxide using "Self-rising" Approach

technology@sc.edu — Thu, 05 Jul 2012 12:52:40 GMT

Reference #: 00768 Invention Description: This invention is a method for creating a hollow structure following a "self-rising" approach, which is virtually a modified evaporation-induced self-assembly method. Development/Demonstration / Validation: This method was applied to cobalt oxide showed high crystallization. SEM imaging indicated sphere formation with 5 µm layers composed of spheres with diameters of 1 µm. TEM analysis has shown porous hollow spheres with very thin shells, some with intact or broken sphere morphology. High magnitude TEM exhibited small particles around 1...

Non-Intrusive Energy Harvesting Systems and Methods

technology@sc.edu — Thu, 05 Jul 2012 12:52:38 GMT

Reference #: 00758The University of South Carolina is offering licensing opportunities for this technology.Potential Applications:The invention is intended to provide energy harvesting for devices which cannot be connected to an energy source directly and for sensors in electric power systems.Advantages and Benefits:Traditional modes of energy supply, such as batteries, have not been able to sufficiently provide the continuous or intermittent power needed by wireless sensors and other miniature devices. The invention is intended to overcome the problems presented by current technology by meeti...

Membrane-Deformation Mapping Technique for Evaluation of Bioprosthetic Heart Valves

technology@sc.edu — Thu, 05 Jul 2012 12:52:37 GMT

Reference #: 00743 Invention Description: The present invention is a method and apparatus for 3D deformation mapping of tissue valve’s leaflet that does not require contact with the valve. This combination provides aimage-based measurement technique based on digital image correlation combined with high-speed stereo imaging to measure the transient three-dimensional deformations of the heart valve leaflets. Background: Bio-prosthetic heart valves (BHV’s) are routinely used as replacements for diseased natural valves. Their lower risks of thrombogenicity and superior he...

Electrochemical Preferential Oxidizer of Carbon Monoxide in Fuel Cell Reformate

technology@sc.edu — Thu, 05 Jul 2012 12:52:37 GMT

Reference #: 00740 The University of South Carolina is offering licensing opportunities for this technology. Potential Applications: Removal of carbon monoxide from reformate hydrogen providing power to PEM fuel cells Advantages and Benefits: Minimal power consumption PEMFC performance retained because Pt anode unaffected by CO in reformate hydrogen Invention Description: Hydrogen (H2) fueled proton exchange membrane fuel cells (PEMFC) offer an efficient alternative electrical power source for portable appliances. As hydrogen storage is a challenge, recent a...

Phosphor for Near UV AIGaN/GaN UV LEDs

technology@sc.edu — Thu, 05 Jul 2012 12:52:35 GMT

Reference #: 00731The University of South Carolina is offering licensing opportunities for this technology.Potential Applications:Luminescence, or the absorption of energy with subsequent emission of light in the visible part of the light spectrum, is the basis of a broad range of applications such as cathode ray tubes, projection televisions, fluorescent tubes and lighting and x-ray and ionizing radiation detectors for medical and technical applications. The new families of phosphors introduced by the present invention can be used to make white-light emitting devices by exposing an appropriat...

Structural Health Monitoring Software and Hardware

technology@sc.edu — Thu, 05 Jul 2012 12:52:35 GMT

Reference #: 00730 Invention Description: The present invention is improved apparatus and methodologies for monitoring structural integrity. More specifically, the invention relates to apparatus and methodologies employing ultrasonic devices and associated analysis software to perform, investigations of a structure. Potential Applications: Structural health monitoring (SHM) is a method of determining the health of a structure from the readings of an array of permanently-attached sensors that are embedded into the structure and monitored over time. Advantages and Benefits: While various i...

A Method for Tissue-Engineering Organ Building Blocks

technology@sc.edu — Thu, 05 Jul 2012 12:52:34 GMT

Reference #: 00727Invention Description:Dr. Jay Potts of the USC School of Medicine has collaborated with Dr. Robert Gourdie from the Medical University of South Carolina to develop a new method for generating tissue-engineered rings (toroids) of aligned contractile cells in vitro. The method provides a novel approach to directing self-organized morphogenetic principles that are intrinsic to 3D networks of coupled cells. Background:Body organs display complex shapes, surfaces, and internal structures including blood vessels. Coupled to morphological complexity, the component tissues of organs ...

Light Induced Activation of Fusarochromanone and its Derivatives for their Use in the Diagnosis and Treatment of Cancer

technology@sc.edu — Thu, 05 Jul 2012 12:52:34 GMT

Reference #: 00718 The University of South Carolina is offering licensing opportunities for an exciting advancement in cancer treatment. Fusarochromanone is a photodynamic therapy that targets cancer cells without destroying healthy cells. It is effective in low doses and has limited side effects. Potential Applications: Fusarochromanone can be used in the treatment of a variety of cancers. Advantages and Benefits: Kills targeted tumor cells without killing normal cells Can be administered locally and in low doses Limited side affects Background: Cancer is the leading cause of dea...

In-situ Alkalinity Measuring Apparatus Utilizing Reverse Gran Titration

technology@sc.edu — Thu, 05 Jul 2012 12:52:34 GMT

Reference #: 00716The University of South Carolina is offering licensing opportunities for this technology, yielding two novel techniques for determining alkalinity in seawater samples.Potential Applications:Rising concentrations of atmospheric carbon dioxide has increasingly impacted the world’s oceans. The largest affect has been the increasingly acidic waters, which have become the focus of marine researchers worldwide. This innovation is meant to test the alkalinity of ocean waters to help assess the health of coral reefs and the delicate ecosystems that exist off our coasts.&n...

Raman Spectroscopy Using a Spatial Heterodyne Spectrometer

technology@sc.edu — Thu, 05 Jul 2012 09:58:43 GMT

Reference #: 00935 The University of South Carolina is offering licensing opportunities for this technology Potential Applications: Ideal for deep-UV laser excitation Pure rotational or ro-vibrational Raman measurements Planetary lander/rover measurements where the wide area collection capability of the instrument allows large areas of the surface to be measured quickly with no loss of spectral resolution Advantages and Benefits: The SHS Raman spectrometer has many unique advantages over all previously reported Raman spectrometers. Typical examples include: [A] Advantages over...

Pretreatment Method for Reduction and/or Elimination of Basal Plane Dislocations Close to Epilayer/Substrate Interface in Growth of SiC Epitaxial Films

technology@sc.edu — Thu, 05 Jul 2012 09:58:42 GMT

Reference #: 00932 The University of South Carolina is offering licensing opportunities for an optimized process for the pre-treatment of the SiC substrate to reduce or eliminate basal plane dislocation and in-grown stacking faults in SiC epitaxial films for the fabrication of state of the art electronics and optical devices. This process offers significant advantages over current techniques because it preserves high BPD conversion rate and is simple (three-minute treatment), non-destructive, and highly efficient process. Advantages and Benefits: Simple, non-destructive, fast, and highly e...

Software and compact hardware for logging power consumption of portable equipment

technology@sc.edu — Thu, 05 Jul 2012 09:58:42 GMT

Reference #: 00927 The University of South Carolina is offering licensing opportunities for this technology. Potential Applications: Power logger for synchronous monitoring and logging of power consumption in portable electronic equipment Specifically designed to be compatible with military radios such as PRC-152, PRC-153, PRC-117 and a whole range of other equipment Advantages and Benefits: A wide range of advantages including low power consumption, long duration data logging (up to 100 hrs.), high accuracy real-time clock, and unique device identification number Invention Descr...

Novel Sulfur-Tolerant Anode Material for Direct Hydrocarbon Solid Oxide Fuel Cells

technology@sc.edu — Thu, 05 Jul 2012 09:58:41 GMT

Reference #: 00920 The University of South Carolina is offering licensing opportunities for this technology Potential Applications: The novel material acts as a promising anode material for high performance SOFCs with high tolerance towards carbon deposition and sulphur poisoning to efficiently convert practical fuels into electricity. Advantages and Benefits: The novel material acts as a SOFC anode material that has high electrode performance. It can simultaneously display both good sulfur tolerance and catalytic activity for hydrogen and hydrocarbon oxidation. ...

Nanoparticles with Multiple Attached Polymer Assemblies and Use Thereof in Polymer Composites

technology@sc.edu — Thu, 05 Jul 2012 09:58:41 GMT

Reference #: 00918The University of South Carolina is offering licensing opportunities for improved methods for synthesizing nanoparticles with multiple polymer assemblies attached.Potential Applications: This technology can be used in composites with improved mechanical properties or optically clear composites. It may also be used in biological and antibacterial applications.Advantages and Benefits:Improves the dispersion of nanoparticles in an organic polymer matrix Allows synthesis of nanoparticles with multiple polymer assemblies attached Nanoparticles with multiple polymer assemblies atta...

Solid Oxide Redox Flow Battery

technology@sc.edu — Thu, 05 Jul 2012 09:58:39 GMT

Reference #: 00898The University of South Carolina is offering licensing opportunities for this technology.Potential Applications:Has application in the large-scale stationary electricity storage for power generation industry.Advantages and Benefits:Maintains high efficiency levels that designated it as an energy-efficient electricity storage It utilizes a Me/MeOx redox couple to store H2 produced by an SOEC on-cell during the charging cycle. This capability is clearly advantageous over combined SOFC-SOEC storage device where the H2 produced by SOEC must be either instantaneously consumed by S...

A Mixed Proton and Carbonate Ion Conductor

technology@sc.edu — Thu, 05 Jul 2012 09:58:39 GMT

Reference #: 00897The University of South Carolina is offering licensing opportunities for this technology.Invention Description:Yttrium-doped barium zirconate (BZY) is now considered as an alternative to the oxygen-ion conductor electrolytes conventionally used in IT-SOFCs due to its higher bulk proton conductivity at low temperatures.BZY has not been fully exploited until now despite its excellent chemical stability because, when prepared as a ceramic polycrystalline material, it suffers from difficult sintering and proton conductivity is decreased by grain boundaries, which have a blocking ...

Rosin-derived Cationic Compounds and Polymers and their Methods of Preparation

technology@sc.edu — Thu, 05 Jul 2012 09:58:37 GMT

Reference #: 00891 Invention Description: Dr. Tang’s invention describes methods for preparing rosin-containing cationic compounds and cationic polymers. The major components from resin acids (or rosin acids), including levopimaric acid, abietic acid, hydroabietic acid, dehydroabietic acid, and maleopimaric acid, are used as substrates to prepare cationic compounds or cationic polymers. Polymer compositions include homopolymers, block copolymers, graft polymers, star polymers, organic polymers, and inorganic hybrids. These materials have the controlled molecular weight of rosin deriva...

A Double Precision Floating Streaming Accumulator Architecture

technology@sc.edu — Thu, 05 Jul 2012 09:58:37 GMT

Reference #: 00890The University of South Carolina is offering licensing opportunities for a double precision floating point stream accumulator.Invention Description:This invention is a SpMV architecture based on a novel streaming reduction circuit and a specialized cache optimized for CSR data. This architecture is implemented on the Convey HC-1, a self-contained heterogeneous system containing a Xeon-based host and an FPGA-based co-processor board with four user programmable Virtex5-LX330 FPGAs. A CSR sparse matrix-vector multiplier was configured and its implementation was analyzed on the C...

Integrated Hazard Assessment Tool (IHAT)

technology@sc.edu — Thu, 05 Jul 2012 09:58:37 GMT

Reference #: 00889 The University of South Carolina is offering licensing opportunities for this technology Potential Applications: Rather than bogging users down in the process of spatial data collection, analysis, and mapping activities, the IHAT will ultimately enable planners and analysts to spend more time creating effective planning and mitigation strategies and programs based on sound scientific (geospatial) analysis. Advantages and Benefits: Data and outputs are not only easily ingested into federally-mandated hazard mitigation plans, but the data also enables users to easily c...

Novel Peptide Derived from Human Apolipoprotein E Inhibits Hepatitis C Virus Entry

technology@sc.edu — Thu, 05 Jul 2012 09:58:37 GMT

Reference #: 00885 The University of South Carolina is offering licensing opportunities for this novel method of blocking and/or treating Hepatitis C Virus. Invention Description: This invention is a human apolipoprotein E (apoE) peptide, designated hEP. hEP blocks Hepatitis C Virus (HCV) entry into hepatocytes. This peptide specifically blocks HCV entry at the attachment step and is effective at sub-micromolar concentrations. Analyses of hEP mapped its anti-HCV activity to a 33 amino acid-long region that harbors the receptor binding domain of human apoE. These results highlight the pot...

Na3FWO4- a Member of a New Scintillator Materials Family (MO4)FAnBm with M=B, Al, Si, P, S, Cr, V, Nb, Ta, Zr, H

technology@sc.edu — Thu, 05 Jul 2012 09:58:36 GMT

Reference #: 00883The University of South Carolina is offering licensing opportunities for this technology Potential Applications:This invention should be useful in lighting and optical host lattices. Advantages and Benefits:Alternative technique for medical imaging Flexible system due to substitution of elements other than tungsten Exquisite control of PL properties is within reach due to the chemical diversity of available MO4n- that can be accommodated in these materials Invention Description:Scintillator materials are used to detect γ-rays, x-rays, neutrons and electr...

Flexible Zn2SnO4/MnO2 Core/Shell Nanocable-Carbon Microfiber Hybrid Composites for Energy Systems

technology@sc.edu — Thu, 05 Jul 2012 09:58:36 GMT

Reference #: 00882The University of South Carolina is offering licensing opportunities for this the use of MnO2 in creating sustainable and renewable power sources.Potential Applications:Dr. Li’s research suggests that a MnO2/ZTO/CMF composite with hierarchical architecture is very promising for next generation, high-performance, flexible super-capacitors.Advantages and Benefits:• Low cost of MnO2• Environmental friendliness of MnO2• Natural abundance of MnO2Invention Description:To meet the urgent need for sustainable and renewable power sources in the modern electronic industry, many efforts...

Determination of the Remaining Life of a Structural System Based on Acoustic Emission Signals

technology@sc.edu — Thu, 05 Jul 2012 09:58:36 GMT

Reference #: 00879The University of South Carolina is offering licensing opportunities for this novel method of determining the life span of a structural system.Potential Applications:The model updating process can be applied in an almost real-time fashion for structural health monitoring applications. Companies that perform inspection of structural systems should have strong interest in this invention (i.e. companies inspecting bridges for state DOTs).Advantages and Benefits:• The model can be continuously updated as new information becomes available, allowing a better prediction of the...

Methods of Treating a Water Sample or a Substrate to Remove Organic Compounds

technology@sc.edu — Thu, 05 Jul 2012 09:58:35 GMT

Reference #: 00875 Keywords: Advanced oxidation processes (AOPs), hydroxyl radical, treatment/remediation, sustainable oxidation Invention Description: The subject invention is a system of equations (a model) that can be used to develop sustained free radical oxidation processes using low energy, environmentally sustainable feedstocks such as Fe salts, atmospheric oxygen, and naturally occurring organic molecules. Background: The oxidation of aqueous Fe(II) by atmospheric dioxygen is associated with the production of several reactive oxygen species (ROS). These include hydrogen peroxide...

Ni Modified Ceramic Anodes for Direct-Methane Solid Oxide Fuel Cells

technology@sc.edu — Thu, 05 Jul 2012 09:58:35 GMT

Reference #: 00873 The University of South Carolina is offering licensing opportunities for Ni-modified ceramic anodes for use in direct-methane solid fuel cells. Invention Description: This invention is a Ni-modified ceramic anode for use in direct-methane solid fuel cells. Dispersion of a small amount of Ni on the proprietary ceramic anode as a catalyst significantly improves the anode performance while avoiding carbon deposition and redox instability from the conventional Ni-cermet anode for direct methane SOFCs. Advantages and Benefits: • Inexpensive anode materials...

Method and Sensor for the Detection of Active Carbon Filters Degradation with EMIS-ECIS PWAS

technology@sc.edu — Thu, 05 Jul 2012 09:58:34 GMT

Reference #: 00872Background:Combined use of electromechanical impedance spectroscopy (EMIS) and electrochemical impedance spectroscopy (ECIS) with piezoelectric wafer active sensors (PWAS) for degradation detection in active carbon filters offers a revolutionary new approach to detect electrical and mechanical changes in active carbon filters. PWAS are the enabling technology for active structural health monitoring (SHM) systems. The motivation for this development is to give a non-intrusive in-situ evaluation method to improve the safety of active carbon filter systems. Invention Description...

Preparation of Cobaltocenium-containing Vinyl Monomers and Their Polymers

technology@sc.edu — Thu, 05 Jul 2012 09:58:34 GMT

Reference #: 00867BackgroundMetallocene-containing polymers have attracted significant attention because they have great potential in catalytic, optical, magnetic and biological applications. This potential is due to metallocenes’ unique geometries and physicochemical properties. Among the metallocene polymers, ferrocene-containing polymers are the most studied. Unlike ferrocene, which has 18 electrons, cobaltocene has 19 electrons. Cobaltocene can readily lose one electron to form stable cobaltocenium (18 electrons), which is isoelectronic with ferrocene. Cobaltocenium polymers are less...

Mixed Carbonate-ion and Oxide-ion conducting membranes and reactors for H2 production with zero CO2 emission

technology@sc.edu — Thu, 05 Jul 2012 09:58:32 GMT

Reference #: 00856 Invention Description: Steam reforming of methane is the most common hydrogen production method in commercial use today. However, one of the major byproducts of the steam reforming process is CO2, a significant contributor to global warming and climate change. Capturing CO2 has therefore become a paramount task for the hydrogen producing industries. This technology involves a novel process that produces pure hydrogen without emissions of CO2. The overall system description and necessary modifications/variations would require limited technological sophisticati...

Sensor Energy Harvesting for Non-Intrusive Monitoring of Power Systems

technology@sc.edu — Thu, 05 Jul 2012 09:58:32 GMT

Reference #: 00855The University of South Carolina is offering licensing opportunities for this technology used in harvesting energy in industrial situations.Potential Applications:Ready for immediate application, the sensor can be applied to industrial situations where there is a high concentration of electromagnetic activity (ie: power sub-stations, etc.). The energy harvesting element can charge the battery of a wireless sensor and/or can provide the necessary voltage and current needed to operate a sensor. This invention has a wide spectrum of applications in power transmission and d...

Up-conversion White-Light Phosphors

technology@sc.edu — Thu, 05 Jul 2012 09:58:29 GMT

Reference #: 00838The University of South Carolina is offering licensing opportunities for this technologyPotential Applications:Frequency up-conversion luminescence has great potential applications in diode-pumped all-solid-state visible lasers, highly efficient next-generation lighting, near-IR photon detectors, high power fiber up-conversion lasers, nm-sized biological labels and new emissive displays. Up-to-date rare earths have mainly been doped into oxyfluoride glasses since oxyfluorides combine the favorable low phonon energy and high up-conversion efficiencies with the high mechanical ...

Wireless Power Transfer to Embedded Sensors

technology@sc.edu — Thu, 05 Jul 2012 09:58:28 GMT

Reference #: 00835The University of South Carolina is offering licensing opportunities for this technologyPotential Applications:Wireless embedded sensors for infrastructure monitoring in bridges, buildings, pipelines, power lines, and dams Hazardous waste processing and removal facilities Nuclear waste monitoring Biomedical applications Advantages and Benefits:Futuristic low-cost solutions that can be embedded within a RFID infrastructure (when the structure itself is built) Dual-function humidity sensor antenna that can be easily integrated within existing or future wireless transceiver modu...

Structural Analysis of the CDK4/cyclin D1 Substrate Recognition Site and Basis for p27 and Inhibitor Binding

technology@sc.edu — Thu, 05 Jul 2012 09:58:27 GMT

Reference #: 00829 Invention Description: An alternative strategy for inhibition of the cyclin dependent kinases in anti-tumor drug discovery is afforded through the substrate recruitment site on the cyclin positive regulatory subunit. This approach offers the potential for generating cell cycle-specific CDK inhibitors and to reduce the inhibition of transcription mediated through CDK7 and 9, commonly observed with ATP competitive compounds. While highly potent peptide and small molecule inhibitors of CDK2/cyclin A, E substrate recruitment have been reported, little information has been gen...

Enhanced Hydrogen Permeation in Nanocrystalline Proton Conducting Ceramics of the Form SrCeO3

technology@sc.edu — Thu, 05 Jul 2012 09:58:27 GMT

Reference #: 00828 The University of South Carolina is offering licensing opportunities for this technology Potential Applications: Implementing this technology to create dense, nanocrystalline ceramics or thin films on porous supported substrates would result in enhanced hydrogen permeation membranes. Advantages and Benefits: Because electron conductivity has been demonstrated to be the limiting factor for hydrogen permeation, any increase in this value results in enhanced permeation: In oxide structures exposed to a reducing hydrogen atmosphere, oxygen is removed from...

Detecting Heat Capacity Changes Due to Surface Inconsistencies using High Absorbance Spectral Regions in the mid-IR

technology@sc.edu — Thu, 05 Jul 2012 09:58:27 GMT

Reference #: 00827The University of South Carolina is offering licensing opportunities for this novel method of visualizing surface inconsistencies.Potential Applications:Visualization of:• Seams between boards• Repairs to drywall• Variations in concrete• Repairs to vehicles• Cracks in foundationAdvantages and Benefits:This method provides a non-destructive, hands-off technique for the visualization of seams between boards, repairs to drywall, variations in concrete, repairs to vehicles, or cracks in foundation. Invention Description:Most materials absorb strongly in the fundamental IR s...

Detecting Surface Stains Using High Absorbance Spectral Regions in the mid-IR

technology@sc.edu — Thu, 05 Jul 2012 09:58:26 GMT

Reference #: 00826 The University of South Carolina is offering licensing opportunities for this technology. Invention Description: The subject invention provides a non-destructive, hands-off technique for the detection of surface coatings in trace concentrations, coatings that are often times invisible to the naked eye. These types of surface stains are detected in the Mid-IR by using high absorbance spectral regions. The method coordinates a thermal infrared sensor or camera and a light source to detect surface films, coatings, or contaminants in concentrations as low as...

A Software Tool for Computing the Net Present value of Carbon Credits for Tidal and Constructed Wetlands

technology@sc.edu — Thu, 05 Jul 2012 09:58:26 GMT

Reference #: 00825 The University of South Carolina is offering licensing opportunities for this technology Potential Applications: • Evaluating ROI for wetlands restoration projects • Real estate valuation • Determining future carbon credits (up to 100 years) Advantages and Benefits: The model provides a means of evaluating the value of existing wetlands or the projected value, in terms of carbon credits, of wetland restorations. Invention Description: State, regional, national, and international initiatives are rapidly being implemented to reduce greenhouse gas emis...

Novel Mixed Ionic and Electronic Conductor Based on Sr2Fe2-xMoxO6 Double Perovskite

technology@sc.edu — Thu, 05 Jul 2012 09:58:26 GMT

Reference #: 00820 The University of South Carolina is offering licensing opportunities for this technology. Potential Applications: The cell with this unique structure has potential application in the field of ‘self-regenerative’ solid oxide fuel cells to overcome electrode deactivation issues. Redox stable and mixed conducting SFM perovskite materials can also find applications in oxygen permeation membranes. Advantages and Benefits: Dr. Chen’s invention demonstrates a novel self-regenerating electrode concept for SOFCs: both the anode and the cathode are the same mat...

A Novel Method to Fabricate High Performance Tubular Solid Oxide Fuel Cells

technology@sc.edu — Thu, 05 Jul 2012 09:58:25 GMT

Reference #: 00819Invention Description:This invention is a proprietary process to produce tubular solid oxide fuel cells (SOFCs). SOFCs have long been considered promising candidates for the next generation energy conversion devices, due to their high electrical conversion efficiencies, environmental benignity, and fuel flexibility. The tubular SOFCs produced with the subject process realize that promise. They can be operated in reversible (both fuel cell and electrolysis) mode with high cell performance and excellent durability. As such, they offer an economically viable alternative for larg...

Composite Mixed Carbonate Ions and Electrons Conducting Membranes and Reactors for CO2 Separation and Capture

technology@sc.edu — Thu, 05 Jul 2012 09:58:25 GMT

Reference #: 00815 Background: The technical approach to reduce CO2 emissions is simply to avoid the emissions to the atmosphere by capturing and storing it at either the pre-combustion or post-combustion stage. At either stage, CO2 has to be separated from either a reducing fuel stream (pre-combustion) or an oxidizing flue gas stream (post-combustion) into a highly concentrated form, from which CO2 can then be further compressed into a liquid form and stored via geologic sequestration. The technologies available for CO2 separation include mechanical scrubbing and poly-amine solvent-ba...

Multi-mode Imaging in the Thermal Infrared for Chemical Contrast Enhancement

technology@sc.edu — Thu, 05 Jul 2012 09:58:24 GMT

Reference #: 00811 Invention Description: This technique relies on a thermal imaging system adapted with a modulated light source. Chemical contrast in the image is enhanced by using AC responses as well as lock-in amplifier techniques to acquire both reflection and emission data about the sample. Potential Applications: One skilled in the art will recognize that this technique can be used for, but is not limited to, the imaging of blood or proteins. Data would suggest this technique could be used to identify any substance that has a unique spectral profile. Advantages and Ben...

Preparation and Applications of Well-Defined Polymers Derived From Rosin

technology@sc.edu — Thu, 05 Jul 2012 09:58:24 GMT

Reference #: 00810Invention Description:The present invention provides an entirely new approach for developing well-defined polymers for the use of rosin in applications ranging from thermoplastic resins to polymer composites. More particularly, methods are provided for preparing well-defined polymers comprising rosin wherein: (i) block copolymers, random copolymers, graft copolymers, star copolymer, or organic/inorganic hybrids contain at least one polymerized monomer derived from rosin; and (ii) rosin-containing block copolymers, random copolymers, graft copolymers, star copolymer or organic...

InN Nanowire Based Multifunctional Sensors

technology@sc.edu — Thu, 05 Jul 2012 09:58:23 GMT

Reference #: 00802 Invention Description: This technology is an indium-nitrogen (InN) nanowire (NW) based multifunctional V-shaped nanocantilever (VNC) sensor for detection of analyte molecules in ambient conditions and investigation of electrical signal propagation in neurons. The special shape and geometry of the nanowires, which can be achieved inexpensively through barrier patterning, allows not only their use as cantilevers, but also transduces their deflection from change in resistance between the two arms. A VNC can both dramatically improve detection sensitivity and provide a ready ...

A High Throughput Assay For Discovering New Inhibitors of the GIRK1/4 Channel

technology@sc.edu — Thu, 05 Jul 2012 09:58:21 GMT

Reference #: 00792 Invention Description: Discovery of new drugs that act on the cardiac IK,Ach has been hampered by the absence of a cell-based high throughput screening system that utilizes IK,Ach. The present invention provides a high throughput methodology for discovering new drugs that bind to and inhibit IK,Ach. In this invention, cells expressing IK,Ach are plated in 96-well culture dishes and treated with potential drugs that inhibit IK,Ach. The activity of IK,Ach is then measured in the presence of muscarinic agent carbachol using a fluorescent imaging plate reader (FLIPR). ...

Discovery of Direct Growth Inhibition of Various Types of Cancer Cells by Fusarochromanone

technology@sc.edu — Thu, 05 Jul 2012 09:58:19 GMT

Reference #: 00337 The University of South Carolina is offering sub-licensing opportunities for a compound that shows promise for the treatment of cancer, arthritis, and other angiogenic diseases. The compound strongly inhibits tumor growth and is also effective in inhibiting angiogenesis. This unique combination of anticancer activity and anti-angiogenic activity makes this compound attractive for clinical development. Potential Applications: This invention offers promise for the treatment of cancer and angiogenic diseases, including arthritis. Advantages and Benefits: Particularly attrac...

Protein Arginine Deiminase Inhibitors as a Novel Therapeutic Strategy for Rheumatoid Arthritis, Cancer and Other Human Diseases

technology@sc.edu — Wed, 27 Jun 2012 13:05:33 GMT

Reference #: 00812Potential Applications: These Protein Arginine Deiminase Inhibitors aid in the treatment of cancer and arthritis. Advantages and Benefits: · The most potent inhibitors of PAD4 activity known to date· Have in vivo applicability· Exhibit cytotoxicity towards cells of cancerous lineage without affecting non-cancerous cells· Trigger cell differentiation into non-cancerous granulocytes Background: ...