Description:
Reference #: 01513
The University of South Carolina is offering licensing opportunities for Nanoparticle for the remodeling of cancer-associated fibroblast
Background:
The biomimetic enzyme activity of the cerium oxide nanoparticle (CeNP) prefers ultrasmall particle size and bare surface. Unfortunately, those two features are not favorable for its in vivo application due to easy aggregation and fast renal filtration. To take advantage of the activity of CeNP for cancer therapy, a tumor targeted cerium oxide nanoparticle system, T-CeNP, has been developed.
Invention Description:
Tumor microenvironment plays a crucial role in the proliferation, migration, invasion, and metastasis of cancer cells. Thus, there is an urgent need for an approach that can remodel the tumor microenvironment. This invention has developed a cancer targeted nanoparticle which can recondition the "soil" for cancer cells to grow. Animal studies proved that the nanoparticle could reduce the size of primary tumor and prevent the post-surgery lung metastasis and liver metastasis of breast cancer.
Potential Applications:
The applications of this technology range from cancer treatment, Alzheimer's disease treatment, to stroke treatment. It greatly benefits these by allowing for better modeling.
Advantages and Benefits:
The innovation offers lower toxicity, high potency, better survival rate, and a low metastatic rate.