Cell Membrane Coated Nanoparticle for Brain Targeted Drug Delivery


Reference #: 01315


The University of South Carolina is offering licensing opportunities for a Cell Membrane Coated Nanoparticle for Brain Targeted Drug Delivery.



Due to the existence of blood brain barrier (BBB), most of the small molecules for the treatment of central neural systems (CNS) diseases cannot cross the BBB. Development of efficient delivery systems for CNS drugs is urgently needed.


Invention Description:

The invention describes the preparation of a brain targeted nanoparticle and its application. The cancer cell membrane coated nanoparticle can effectively pass the blood brain barrier and specifically target brain tissue.


Potential Applications:

The resulting nanocarrier can be applied for the treatment of Alzheimer's disease, traumatic brain injury, multiple sclerosis, stroke, Parkinson’s disease, brain tumor, acute spinal cord injury, HIV encephalitis, Down syndrome, rabies, epilepsy, Huntington's disease, and other CNS diseases.


Advantages and Benefits:

The nanocarrier can effectively pass the BBB and boost the efficacy of drugs for the treatment of CNS diseases.



Brain targeting efficiency has been tested in vivo. Evaluating the therapeutic efficacy of the

nanoparticle is ongoing.


Patent Information:
Title App Type Country Serial No. Patent No. File Date Issued Date Expire Date Patent Status
Nanoparticles for Brain Targeted Drug Delivery Utility United States 16/278,777 10,842,755 2/19/2019 11/24/2020   Issued
For Information, Contact:
Technology Commercialization
University of South Carolina
Peisheng Xu
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