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Structural Analysis of the CDK4/cyclin D1 Substrate Recognition Site and Basis for p27 and Inhibitor Binding

Reference #: 00829 Invention Description: An alternative strategy for inhibition of the cyclin dependent kinases in anti-tumor drug discovery is afforded through the substrate recruitment site on the cyclin positive regulatory subunit. This approach offers the potential for generating cell cycle-specific CDK inhibitors and to reduce the inhibition...

Published: 9/2/2022 | Inventor(s): Campbell Mcinnes, Shu Liu

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Category(s): Biomedical and Life Sciences